Search Results
Educational Resources
Bioinformatics is a subdiscipline of biology and computer science concerned with the acquisition, storage, analysis, and dissemination of biological data.
… about those sequences. Scientists and clinicians use databases that organize and index such biological information …
Research at NHGRI
The Technology Transfer Office is responsible for transferring NHGRI technologies to the private sector and exchanging research materials with outside groups.
News Release
The zebrafish is a powerhouse tool that helps researchers better understand the genes that are implicated in disease.
… researchers, the reasons for using zebrafish as their model organism of choice are as varied as the diseases they study. … For Dr. Brooks' research program, using the zebrafish as a model is both practical and eye-opening."The zebrafish …
Fact Sheets
Comparative genomics is a field of biological research in which researchers compare the complete genome sequences of different species.
… Human Genome Project sequenced the genomes of a number of model organisms that are commonly used as surrogates in … as ENCODE (Encyclopedia of DNA Elements) and modENCODE (model organism Encyclopedia of DNA Elements) have compared and …
The Genomics Landscape
In 2022, The Genomics Landscape spotlighted genomic data sharing each month in a series of entries. This page contains a collection of each of those entries.
… such as the database of Genotypes and Phenotypes (dbGaP), model organism databases (e.g., Mouse Genome Informatics and Xenbase ), and …
News Release
A genetic mutation that triggers bladder cancer in dogs is identical to a mutation that is implicated in multiple human cancers.
… way that canines may come to our aid-as a powerful animal model for research into human cancer. … A genetic mutation … which is not inherited but rather arises during an organism's lifetime, alters the protein and causes cells to … cancers are similar, and dogs already have served as a model in cancer research. They were central to immune system …
News Release
Scientists are using an exciting gene editing tool called CRISPR/Cas9 to protect plants from harmful DNA viruses, strengthening the plant's protections.
… called Cas9) allows scientists to snip out segments of an organism's DNA and insert new ones. While using the system to … species was chosen because it is well understood as a model organism, and new findings can be easily applied to other …
Fact Sheets
Deoxyribonucleic acid (DNA) is a molecule that contains the biological instructions that make each species unique.
… to DNA found in the cell's nucleus as nuclear DNA. An organism's complete set of nuclear DNA is called its genome. …  … DNA contains the instructions needed for an organism to develop, survive and reproduce. To carry out …
Fact Sheet
Viruses are bundles of genetic material wrapped in a protein coat that can infect living things.
… ways, including by:    Direct contact with an infected organism, such as being bitten by a mosquito infected with … no symptoms. However, when many viral particles infect an organism's cells at the same time, they may cause anything … acid that make the viruses work differently in the host organism, such as by changing the viral protein coat …
News Release
NIH researchers identified a novel role for a gene known as heat shock protein 60, finding it is critical in tissue regeneration and wound healing.
… dramatically accelerates wound closure in a diabetic mouse model. … The study also describes the mechanism by which this … npj Regenerative Medicine . "This gene is found in every organism from bacteria to man. We have shown that in … ability to regenerate. Using zebrafish - an ideal model for this work because fish can regenerate many tissues, …