Program Director, Functional Genomics

Division of Genome Sciences

Education

Ph.D. University of California, San Francisco, 1992

Biography

Dr. Pazin joined the National Human Genome Research Institute's NHGRI's Extramural Research Program in 2011. Mike is part of the NHGRI team overseeing the ENCODE project, generating an Encyclopedia of DNA Elements from the human genome, and the modENCODE project, identifying functional elements in the fly and worm genomes. He manages a portfolio of grants in functional genomics. He is also a member of the NHGRI Data Access Committee.

Prior to joining NHGRI, Dr. Pazin was a principal investigator conducting research on the role of chromatin remodeling in gene regulation, at Massachusetts General Hospital/Harvard Medical School and the National Institute on Aging. This research was performed using cell-free (biochemical) assays and cell-based (single-gene and genomic) assays using T helper cells and neurons as model systems. He received his B.S. in chemistry from MIT in Cambridge, Massachusetts, his Ph.D. in cell biology from University of California, San Francisco (UCSF), and completed postdoctoral training at University of California, San Diego (UCSD).

Publications

De S, Wurster AL, Precht P, Wood WH 3rd, Becker KG, Pazin MJ. Dynamic BRG1 Recruitment during T Helper Differentiation and Activation Reveals Distal Regulatory Elements. Mol Cell Biol, 31:1512-27. 2011. [PubMed]

Precht P, Wurster AL, Pazin MJ. The SNF2H chromatin remodeling enzyme has opposing effects on cytokine gene expression. Mol Immunol, 47:2038-46. 2010. [PubMed]

Ishii H, Du H, Zhang Z, Henderson A, Sen R, Pazin MJ. Mi2beta shows chromatin enzyme specificity by erasing a DNase I-hypersensitive site established by ACF. J Biol Chem, 284:7533-41. 2009. [PubMed]

Xie Y, Kole S, Precht P, Pazin MJ, Bernier M. S-glutathionylation impairs signal transducer and activator of transcription 3 activation and signaling. Endocrinology, 150:1122-31. 2009. [PubMed]

Wurster AL, Pazin MJ. BRG1-mediated chromatin remodeling regulates differentiation and gene expression of T helper cells. Mol Cell Biol, 28:7274-85. 2008. [PubMed]

Zhang P, Pazin MJ, Schwartz CM, Becker KG, Wersto RP, Dilley CM, Mattson MP. Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cells. Curr Biol, 18:1489-94. 2008. [PubMed]

Du H, Ishii H, Pazin MJ, Sen R. Activation of 12/23-RSS-dependent RAG cleavage by hSWI/SNF complex in the absence of transcription. Mol Cell, 31:641-9. 2008. [PubMed]

Pazin MJ, Bhargava P, Geiduschek EP, Kadonaga JT. Nucleosome mobility and the maintenance of nucleosome positioning. Science, 276:809-12. 1997. [PubMed]

Pazin MJ, Sheridan PL, Cannon K, Cao Z, Keck JG, Kadonaga JT, Jones KA. NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro. Genes Dev, 10:37-49. 1996. [PubMed]

Pazin MJ, Kamakaka RT, Kadonaga JT. ATP-dependent nucleosome reconfiguration and transcriptional activation from preassembled chromatin templates. Science, 266:2007-11. 1994. [PubMed]

Last updated: December 4, 2013