One of the central problems in biology is understanding how genomic variation affects genome function to influence phenotypes. In 2019, the National Human Genome Research Institute hosted the workshop "From Genome to Phenotype: Genomic Variation Identification, Association, and Function in Human Health and Disease". Based on the recommendations from the workshop report, NHGRI is initiating a new program-the Impact of Genomic Variation on Function (IGVF) Consortium to develop a framework for systematically understanding the effects of genomic variation on genome function and how these effects shape phenotypes. IGVF is a research consortium that will bring investigators together in a highly collaborative effort to examine how genomes function, how genome function shapes phenotypes, and how these processes are influenced by genomic variation. The program will utilize emerging experimental and computational genomic approaches to build a catalog of the impact of genomic variants on genome function and phenotypes.
Program Staff

- Program Director, Functional Genomics
- Division of Genome Sciences

- Program Director Computational Genomics and Data Science
- Division of Genome Sciences

- Program Director
- Division of Genome Sciences
Last updated: December 18, 2020