NHGRI logo

Impact of Genomic Variation on Function (IGVF) Consortium

The IGVF will develop a framework for systematically understanding the effects of genomic variation on genome function and how these effects shape phenotypes.

One of the central problems in biology is understanding how genomic variation affects genome function to influence phenotypes. In 2019, the National Human Genome Research Institute hosted the workshop "From Genome to Phenotype: Genomic Variation Identification, Association, and Function in Human Health and Disease".  Based on the recommendations from the workshop report, NHGRI is initiating a new program-the Impact of Genomic Variation on Function (IGVF) Consortium to develop a framework for systematically understanding the effects of genomic variation on genome function and how these effects shape phenotypes. IGVF is a research consortium that will bring investigators together in a highly collaborative effort to examine how genomes function, how genome function shapes phenotypes, and how these processes are influenced by genomic variation. The program will utilize emerging experimental and computational genomic approaches to build a catalog of the impact of genomic variants on genome function and phenotypes.

Events

Funding Opportunities

Notices

Request for Applications

  • RFA-HG-20-043: Systematic Characterization of Genomic Variation on Genomic Function and Phenotype (UM1 Clinical Trial Not Allowed)
    Application Receipt Date(s): November 4, 2020
    Expiration Date: November 5, 2020
     
  • RFA-HG-20-044: Defining Genomic Influence on Gene Network Regulation (U01 Clinical Trial Not Allowed)
    Application Receipt Date(s): November 4, 2020
    Expiration Date: November 5, 2020
     
  • RFA-HG-20-045: Single-cell Profiling of Regulatory Element and Gene Activity in Relationship to Genome Function (UM1 Clinical Trial Not Allowed)
    Application Receipt Date(s): November 4, 2020
    Expiration Date: November 5, 2020
     
  • RFA-HG-20-046: Genomic Variation and Function Data and Administrative Coordinating Center (U24 Clinical Trial Not Allowed)
    Application Receipt Date(s): November 4, 2020
    Expiration Date: November 5, 2020
     
  • RFA-HG-20-047: Developing Predictive Models of the Impact of Genomic Variation on Function (U01 Clinical Trial Not Allowed)
    Application Receipt Date(s): November 4, 2020
    Expiration Date: November 5, 2020
     
  • Funding Opportunities

    Notices

    Request for Applications

    • RFA-HG-20-043: Systematic Characterization of Genomic Variation on Genomic Function and Phenotype (UM1 Clinical Trial Not Allowed)
      Application Receipt Date(s): November 4, 2020
      Expiration Date: November 5, 2020
       
    • RFA-HG-20-044: Defining Genomic Influence on Gene Network Regulation (U01 Clinical Trial Not Allowed)
      Application Receipt Date(s): November 4, 2020
      Expiration Date: November 5, 2020
       
    • RFA-HG-20-045: Single-cell Profiling of Regulatory Element and Gene Activity in Relationship to Genome Function (UM1 Clinical Trial Not Allowed)
      Application Receipt Date(s): November 4, 2020
      Expiration Date: November 5, 2020
       
    • RFA-HG-20-046: Genomic Variation and Function Data and Administrative Coordinating Center (U24 Clinical Trial Not Allowed)
      Application Receipt Date(s): November 4, 2020
      Expiration Date: November 5, 2020
       
    • RFA-HG-20-047: Developing Predictive Models of the Impact of Genomic Variation on Function (U01 Clinical Trial Not Allowed)
      Application Receipt Date(s): November 4, 2020
      Expiration Date: November 5, 2020
       

Program Goals

  1. Systematic perturbation of the genome to assess the impact of genomic variation on genome function and phenotype
     
  2. High-resolution identification of where and when genes and regulatory elements function
     
  3. Advancement of network-level understanding of the influence of genetic variation and genome function on phenotype
     
  4. Development and testing of innovative predictive models of the impact of genomic variation on genome function
     
  5. Generation of a resource centered on a catalog of variant impacts and including data, tools, and models that will be shared with the broader research community
     
  6. Enabling others to perform related studies using these approaches.
  • Program Goals
    1. Systematic perturbation of the genome to assess the impact of genomic variation on genome function and phenotype
       
    2. High-resolution identification of where and when genes and regulatory elements function
       
    3. Advancement of network-level understanding of the influence of genetic variation and genome function on phenotype
       
    4. Development and testing of innovative predictive models of the impact of genomic variation on genome function
       
    5. Generation of a resource centered on a catalog of variant impacts and including data, tools, and models that will be shared with the broader research community
       
    6. Enabling others to perform related studies using these approaches.

Program Staff

Mike Pazin, Ph.D.
Mike Pazin, Ph.D.
  • Program Director, Functional Genomics
  • Division of Genome Sciences
Daniel A. Gilchrist, Ph.D.
Daniel A. Gilchrist, Ph.D.
  • Program Director Computational Genomics and Data Science
  • Division of Genome Sciences
Stephanie Morris
Stephanie A. Morris, Ph.D.
  • Program Director
  • Division of Genome Sciences

Last updated: September 2, 2020