Division of Genome Sciences

Genome Technology Program

Illumina HiSeq Flow Cell

Genome Technology Program Overview

The Genome Technology program supports research to develop new methods, technologies and instruments that enable rapid, low-cost determination of DNA sequence, SNP genotyping (Genetic Variation Program) and functional genomics (broadly defined) experiments (Functional Analysis Program). Priorities include the refinement of current technologies to increase efficiency and decrease cost while maintaining or improving data quality, and the development of completely novel approaches to achieve orders-of-magnitude improvement. Integration of process steps is key to achieving these goals.

The program also supports and coordinates transfer of technology from developers to users, and promotes collaborative, multidisciplinary programs that closely integrate research projects at academic and industrial laboratories.

The National Human Genome Research Institute (NHGRI) participates in numerous trans-NIH efforts, including one on bioengineering research. The development of integrated concepts and tools for genomic research benefits from bioengineering research, methods and approaches. NHGRI supports bioengineering research through grants made in response to NHGRI program announcements and requests for application, and through NHGRI participation in trans-NIH bioengineering program announcements, such as the Bioengineering Research Grants (BRG) and Bioengineering Research Partnerships (BRP) programs and other Funding Opportunities that are listed below.

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Genome Technology Program Related Information

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Genome Technology Program Reports

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Genome Technology Program Policies

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Genome Technology Program Funding Opportunities

NHGRI Funding Opportunities

RFA-HG-13-005 [grants.nih.gov]: Revolutionary Genome Sequencing Technologies - The $1000 Genome (SBIR [R43/R44])
Letters of intent are due October 1, 2013, and applications are due October 18, 2013

RFA-HG-13-006 [grants.nih.gov]: Revolutionary Genome Sequencing Technologies - The $1000 Genome (R21)
Letters of intent are due September 1, 2013, and applications are due October 18, 2013.

RFA-HG-13-007 [grants.nih.gov]: Revolutionary Genome Sequencing Technologies - The $1000 Genome (R01)
Letters of intent are due September 1, 2013, and applications are due October 18, 2013

Many other solicitations are appropriate means for submitting genomic technology development grant applications. Please see NHGRI's Funding Opportunities page at NHGRI Funding Opportunities

Expired Grant Solicitations

 

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Genome Technology Program Advanced Sequencing Technology Awards

In 2004, NHGRI initiated a coordinated effort to support the development of technologies to dramatically reduce the cost of DNA sequencing, a move aimed at broadening the applications of genomic information in medical research and health care.

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Genome Technology Features

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Genome Technology Program Bibliography: Publications and Patents

NHGRI launched an ambitious program in 2004 to reduce the cost of full mammalian genome sequencing initially by 100-fold and subsequently by an additional 100-fold, aiming ultimately at about $1,000. Below, listed by Principal Investigator, are citations and links to many of the articles and patents resulting from this program and closely related research.

Genome Technology Program Publications and PatentsPDF file

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Genome Technology Program Staff

Program Directors
Jeffery Schloss, Ph.D.
E-mail: schlossj@exchange.nih.gov

Michael Smith, Ph.D.
E-mail: smithmw@mail.nih.gov

Address
National Human Genome Research Institute
National Institutes of Health
5635 Fishers Lane
Suite 4076, MSC 9305
Bethesda, MD 20892-9305
Phone: (301) 496-7531
Fax: (301) 480-2770

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Last Updated: May 1, 2014