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Numerous National Human Genome Research Institute (NHGRI) technologies, inventions and biological materials are available for licensing, including candidate gene therapy-based therapeutics, mouse models of genetic disorders and a diverse range of well-characterized human-derived cell lines. For a complete list of our technologies as well as a list of technologies available from all other NIH Institutes, search the NIH Office of Technology Transfer

Patented and Patent-Pending Technologies

Assay for Predicting the Time of Onset of Niemann-Pick Disease Type C (NPC)
DHHS Reference No.: E-060-2013
U.S. Patent 9,983,200 issued on May 29, 2018
Lead Inventor: William J. Pavan, Ph.D. (NHGRI)
Office of Technology Transfer Abstract

Gene Therapy for Niemann-Pick Disease Type C (NPC)
DHHS Reference No.: E-185-2014
PCT Application PCT/US2016/026524; national phases entered in the U.S., Europe, and Canada in October 2017
Lead Inventor: Charles P. Venditti, M.D., Ph.D.
Office of Technology Transfer Abstract

Synthetic Methylmalonyl-CoA Mutase Transgene for the Treatment of Mut Class Methylmalonic Acidemia (MMA)
DHHS Reference No.: E-243-2012
U.S. Patent 9,719,080 issued August 1, 2017
U.S. Patent 9,944,918 issued April 17, 2018
U.S. Application 15/633,964, filed June 27, 2017
EP Patent 2968602 issued August 30, 2017; validated in Belgium, Switzerland, Germany, Denmark, Spain, France, U.K., Ireland, Italy, Luxembourg, Netherlands, Sweden, August 30, 2017
Lead Inventor: Charles P. Venditti, M.D., Ph.D. (NHGRI)
Office of Technology Transfer Abstract

Device and Method for Direct Measurement of In Vivo Oxidation
DHHS Reference No.: E-099-2009
U.S. Patent 8,293,187 Issued October 23, 2012
U.S. Patent 8,721,988 Issued May 13, 2014
Lead Inventor: Charles P. Venditti, M.D., Ph.D. (NHGRI)
Office of Technology Transfer Abstract
 

Research Materials

Mouse Models

Mouse Model of Hutchinson-Gilford Progeria Syndrome and Vascular Abnormalities
DHHS Reference No.: E-243-2011
Lead Inventors: Michael R. Erdos (NHGRI) and Francis S. Collins, M.D., Ph.D. (NHGRI)

Murine Model of Niemann-Pick Disease Type C
DHHS Reference No.: E-004-2011
Lead Inventor: William J. Pavan, Ph.D., (NHGRI)

Mouse Model of Diamond-Blackfan Anemia
DHHS Reference No.: E-294-2012
Lead Inventor: William J. Pavan, Ph.D., (NHGRI)
Federal Register Description

 

Other Research Materials

Addresses

Please use the following mailing address for First Class mail:

Technology Transfer Office
National Human Genome Research Institute (NHGRI)
National Institutes of Health (NIH)
6700B Rockledge Drive, MSC 6907
Bethesda, MD 20892-6907
Phone: (301) 402-2537
Fax: (301) 402-9722

Address for Deliveries (FedEx, UPS, etc.):

Technology Transfer Office
National Human Genome Research Institute (NHGRI)
National Institutes of Health (NIH)
6700B Rockledge Drive, Room 3168
Bethesda, MD 20817

Last updated: September 27, 2023