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Implementing Genomics in Practice (IGNITE) II: Pragmatic Clinical Trials Network

IGNITE II supports a network of multi-site clinical groups involving diverse settings and populations to conduct 2-3 pragmatic clinical trials of genomic medicine interventions.

Overview

The Implementing Genomic in Practice (IGNITE) Network was established in 2013 (RFA-HG-12-006RFA-HG-12-007 and RFA-HG-13-004) to develop methods for incorporating genomic information into clinical care and explore the methods for effective implementation, diffusion, and sustainability in diverse clinical settings. The first phase of the network, IGNITE I, was a consortium of collaborative genomic medicine pilot Demonstration Projects designed to demonstrate the feasibility of, and develop methods for, incorporating an individual patient's genomic findings into his or her clinical care.

The next phase of IGNITE, IGNITE II (RFA-HG-17-008RFA-HG-17-009, and RFA-HG-17-010) will support a network of multi-site Clinical Groups (CGs) involving diverse settings and populations to conduct 2-3 pragmatic clinical trials of genomic medicine interventions. The goals of these pragmatic clinical trials will be:

  1. To measure the clinical utility and cost-effectiveness of genomic medicine interventions.
  2. To assess approaches for real-world application of genomic medicine in diverse clinical settings.
  3. To produce generalizable knowledge on the types of genomic medicine interventions requiring randomized clinical trials and effective methods for conducting them

Investigators

Study Investigators
  • Principal Investigator: Julie Johnson, Pharm.D., University of Florida
  • Principal Investigator: Todd Skaar, Ph.D., Indiana University
    MPI: Paul Dexter, M.D., Indiana University
  • Principal Investigator: Carol Horowitz, M.P.H., M.D., Mount Sinai School of Medicine
  • Principal Investigator: Lori Orlando, M.H.S., M.D., Duke University
  • Principal Investigator: Josh Peterson, M.D., Vanderbilt University Medical Center
    MPI: Joshua Denny, M.D., Vanderbilt University Medical Center
Coordinating Center
  • Principal Investigator: Geoffrey Ginsburg, MD, PhD, Duke University School of Medicine
    MPI: Hrishikesh Chakraborty, M.S., PhD, Duke University School of Medicine

Funding Opportunities

  • RFA-HG-17-009 Implementing Genomics in Practice (IGNITE) II: Pragmatic Clinical Trials Enhanced Diversity Clinical Groups (U01) (Expired)
    Expiration Date: Nov 05, 2017

    • NOT-HG-17-014 Notice of Applicant Information Webinar for NHGRI IGNITE II RFAs: RFA-HG-17-008, RFA-HG-17-009 and RFA-HG-17-010

Program Staff

Simona Volpi, Pharm.D., Ph.D.
Simona Volpi, Ph.D.
  • Program Director
  • Division of Genomic Medicine
Ebony B. Madden, Ph.D.
Ebony B. Madden, Ph.D.
  • Program Director
  • Division of Genomic Medicine
Nicole C. Lockhart, Ph.D.
Nicole C. Lockhart, Ph.D.
  • Health Sciences Administrator
  • Division of Genomics and Society
Sylvia Garvey
Sylvia Garvey, M.P.H., C.P.H.
  • Program Specialist
  • Division of Genomic Medicine