Serres-Armero A, Davis BW, Povolotskaya IS, Morcillo-Surarez C, Plassais J, Juan D, Ostrander EA, Marques-Bonet T. Copy number variation underlies complex phenotypes in domestic dog breeds and other canids. Genome Res. 2020. (In Press)
Surbakti S, Parker HG, McIntyre JK, Maury HK, Cairns KM, Selvig M, Pangau-Adam M, Safonpo A, Numberi L, Runtuboi DYP, Davis BW, Ostrander EA. New Guinea highland wild dogs are the original New Guinea Singing dogs. Proc Natl Acad Sci U S A. Sep 29;117(39):24369-24376. doi:10.1073/pnas.2007242117. 2020. [PubMed]
Wang T, Ma J, Hogan AN, Fong S, Licon K, Tsui B, Kreisberg JF, Adams PD, Carvunis AR, Bannasch DL, Ostrander EA, Ideker T. Quantitative translation of dog-to-human aging by conserved remodeling of the DNA methylome. Cell Syst. Aug 26;11(2):176-185.e6. doi:10.1016/j.cels.2020.06.006. 2020. [PubMed]
Parker HG, Dhawan D, Harris AC, Ramos-Vara JA, Davis BW, Knapp DW, Ostrander EA. RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors. BMC Cancer. Mar 24;20(1):251. doi:10.1186/s12885-020-06737-0. 2020. [PubMed]
Ostrander EA, Wang G-D, Larson G, vonHoldt BM, Davis BW, Jagannathan V, Hitte C, Wayne RK, Zhang, Y-P, Dog10K Consortium. Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes, and health. Natl Sci Rev. Jul;6(4):810-824. doi:10.1093/nsr/nwz049. 2019. [PubMed]
Plassais J, Kim J, Davis BW, Karyadi DM, Hogan AN, Harris AC, Decker B, Parker HG, Ostrander EA. Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology. Nat Comm. Apr 2;10(1):1489. doi:10.1038/s41467-019-09373-w. 2019. [PubMed]
Kim J, Williams FJ, Dreger DL, Plassais J, Davis BW, Parker HG, Ostrander EA. Genetic selection of athletic success in sport hunting dogs. Proc Natl Acad Sci U S A. Jul 24;115(30):E7212-E7221. doi:10.1073/pnas.1800455115. 2018. [PubMed]
Ostrander EA, Wayne RK, Freedman AH, Davis BW. Evolutionary genetics of the dog. Nature Rev Genet. Dec;18(12):705-720. doi:10.1038/nrg.2017.67. 2017. [PubMed]
vonHoldt BM, Shuldiner E, Janowitz-Koch I, Kartzinel RY, Hogan A, Brubaker L, Wanser S, Stahler D, Wynne CDL, Ostrander EA, Sinsheimer JS, Udell MAR. Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs. SciAdvances. Jul 19;3(7):e1700398. doi:10.1126/sciadv.1700398. 2017. [PubMed]
Parker HG, Dreger DL, Rimbault M, Davis BW, Mullen AM, Carpintero-Ramirez G, Ostrander EA.. Genomic analysis reveals the influence of geographic origin, immigration and cross-breed introgression on modern dog breed development. CellReports. Apr 25;19(4):697-708. doi:10.1016/j.celrep.2017.03.079. 2017. [PubMed]
Plassais J, Rimbault M, Williams FJ, Davis BW, Schoenebeck JJ, Ostrander EA. Analysis of large versus small dogs reveals three genes on the canine X chromosome associated with body weight, muscling and back fat thickness. PLoS Genet. Mar 3;13(3):e1006661. doi:10.1371/journal.pgen.1006661. 2017. [PubMed]
Parker HG, Harris A, Dreger DL, Ostrander EA. The bald and the beautiful: hairlessness in domestic dog breeds. PhilosophTransactRSocLondBBiolSci. Feb 5;372(1713):20150488. doi:10.1098/rstb.2015.0488. 2017. [PubMed]
Dreger DL, Rimbault M, Davis BW, Bhatnager A, Parker HG, Ostrander EA. Whole-genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic-trait mapping. Dis Mod Mech. Dec 1;9(12):1445-1460. doi:10.1242/dmm.027037. 2016. [PubMed]
Decker B, Karyadi DM, Davis BW, Karlins E, Tillmans LS, Stanford JL, Thibodeau SN, Ostrander EA. Biallelic BRCA mutations shape the somatic mutational landscape of aggressive prostate tumors. Am J Hum Genet. May 5;98(5):818-829. doi:10.1016/j.ajhg.2016.03.003. 2016. [PubMed]
Decker B, Davis BW, Rimbault M, Long AH, Karlins E, Jagannathan V, Reiman R, Parker HG, Drögemüller C, Corneveaux JJ, Chapman ES, Trent JM, Leeb T, Huentelman JM, Wayne RK, Karyadi DM, Ostrander EA. Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor. GenomeRes. Nov;25(11):1646-55. doi:10.1101/gr,190314.115. 2015. [PubMed]
Decker B, Parker HG, Dhawan D, Kwon EM, Karlins E, Davis BW, Ramos-Vara JA, Bonney PL, McNiel EA, Knapp DW, Ostrander EA. Homologous mutation to human BRAF V600E is common in naturally occurring canine bladder cancer-evidence for a relevant model system and urine-based diagnostic test. Mol Canc Res. Jun;13(6):993-1002. doi:10.1158/1541-7786.MCR-14-0689. 2015. [PubMed]
Parker HG, Ostrander EA. Cancer. Hiding in plain view-an ancient dog in the modern world. Science. Jan 24;343(6169):376-8. doi:10.1126/science.1248812. 2014. [PubMed]
Rimbault M, Beale HC, Schoenebeck JJ, Hoopes BC, Allen JJ, Kilroy-Glynn P, Wayne RK, Sutter NB, Ostrander EA. Derived variants at six genes explain nearly half of size reduction in dog breeds. Genome Res. Dec;23(12):1985-95. doi:10.1101/gr.157339.113. 2013. [PubMed]
Karyadi DM, Karlins E, Decker B, vonHoldt BM, Carpintero-Ramirez G, Parker HG, Wayne RK, Ostrander EA. A copy number variant at the KITLG locus likely confers risk for canine squamous cell carcinoma of the digit. PLoSGenetics. Mar;9(3):e1003409. doi:10.1371/journal.pgen.1003409. 2013. [PubMed]
Schoenebeck JJ, Hutchinson SA, Byers A, Beale HC, Carrington B, Faden DL, Rimbault M, Decker B, Kidd JM, Sood R, Boyko AR, Fondon JW 3rd, Wayne RK, Bustamante CD, Ciruna B, Ostrander EA. Variation of BMP3 contributes to dog breed skull diversity. PLoSGenet. 8(8):e1002849. doi:10.1371/journal.pgen.1002849. 2012. [PubMed]
Huson HJ, vonHoldt BM, Rimbault M, Byers AM, Runstadler JA, Parker HG, Ostrander EA. Breed-specific ancestry studies and genome-wide association analysis highlight an association between the MYH9 gene and heat tolerance in Alaskan sprint racing sled dogs. MammGenome. Feb;23(1-2):178-94. doi:10.1007/s00335-011-9374-y. 2012. [PubMed]
Boyko AR, Quignon P, Li L, Schoenebeck JJ, Degenhardt JD, Lohmueller KE, Zhao K, Brisbin A, Parker HG, vonHoldt BM, Cargill M, Auton A, Reynolds A, Elkahloun AG, Castelhano M, Mosher DS, Sutter NB, Johnson GS, Novembre J, Hubisz MJ, Siepel A, Wayne RK, Bustamante CD, Ostrander EA. A simple genetic architecture underlies morphologic variation in dogs. PLoS Biol. Aug 10;8(8):e1000451. doi:10.1371/journal.pgen.1000451. 2010. [PubMed]
vonHoldt BM, Pollinger JP, Lohmueller KE, Han E, Parker HG, Quignon P, Degenhardt JD, Boyko AR, Earl DA, Auton A, Reynolds A, Bryc K, Brisbin A, Knowles JC, Mosher DS, Spady TC, Elkahloun A, Geffen E, Pilot M, Jedrzejewski W, Greco C, Randi E, Bannasch D, Wilton A, Shearman J, Musiani M, Cargill M, Jones PG, Qian Z, Huang W, Ding ZL, Zhang YP, Bustamante CD, Ostrander EA, Novembre J, Wayne RK. Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication. Nature. Apr 8;464(7290):898-902. doi:10.1038/nature08837. 2010. [PubMed]
Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, vonHoldt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, André C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA. Coat variation in the domestic dog is governed by variants in three genes. Science. Oct 2;326(5949):150-3. doi:10.1126/science.1177808. 2009. [PubMed]
Parker HG, vonHoldt BM, Quignon P, Margulies EH, Shao S, Mosher DS, Spady TC, Elkahloun A, Cargill M, Jones PG, Maslen CL, Acland GM, Sutter NB, Kuroki K, Bustamante CD, Wayne RK, Ostrander EA. An expressed Fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs. Science. Aug 21;325(5943):995-8. doi:10.1126/science.1173275. 2009. [PubMed]
Parker HG, Kukekova AV, Akey DT, Goldstein O, Kirkness EF, Baysac KC, Mosher DS, Aguirre GD, Acland GM, Ostrander EA. Breed relationships facilitate fine mapping studies: A 7.8 Kb deletion cosegregates with collie eye anomaly across multiple dog breeds. Genome Res. Nov;17(11):1562-71. doi:10.1101/gr.6772807. 2007. [PubMed]
Mosher DS, Quignon P, Bustamante CD, Sutter NB, Mellersh CS, Parker HG, Ostrander EA. A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. PLoS Genet. May 25;3(5):e79. doi:10.1371/journal.pgen.0030079. 2007. [PubMed]
Sutter NB, Bustamante CD, Chase K, Gray MM, Zhao K, Zhu L, Padhukasahasram B, Karlins E, Davis S, Jones PG, Quignon P, Johnson GS, Parker HG, Fretwell N, Mosher DS, Lawler DF, Satyaraj E, Nordborg M, Lark KG, Wayne RK, Ostrander EA. A single IGF1 Allele is a major determinant of small size in dogs. Science. Apr 6;316(5821):112-5. doi:10.1126/science.1137045. 2007. [PubMed]
Agalliu I, Kwon EM, Zadory D, McIntosh L, Thompson J, Stanford JL, Ostrander EA. Germline mutations in the BRCA2 gene and susceptibility to hereditary prostate cancer. Clin Cancer Res. Feb 1;13(3):839-43. doi:10.1158/1078-0432.CCR-06-2164. 2007. [PubMed]
Parker HG, Kruglyak L, Ostrander EA. Molecular genetics: DNA analysis of a putative dog clone. Nature. Mar 9;440(7081):E1-2. doi:10.1038/nature04685. 2006. [PubMed]
Sutter NB, Eberle MA, Parker HG, Pullar BJ, Kirkness EF, Kruglyak L, Ostrander EA. Extensive and breed specific linkage disequilibrium in Canis familiaris. Genome Res. Dec;14(12):2388-96. doi:10.1101/gr.3147604. 2004. [PubMed]
Parker HG, Kim LV, Sutter NB, Carlson S, Lorentzen TD, Malek TB, Johnson GS, DeFrance HB, Ostrander EA, Kruglyak L. Genetic structure of the purebred domestic dog. Science. May 21;304(5674):1160-4. doi:10.1126/science.1097406. 2004. [PubMed]
Lingaas F, Comstock KE, Kirkness EF, Sørensen A, Aarskaug T, Hitte C, Nickerson ML, Moe L, Schmidt LS, Thomas R, Breen M, Galibert F, Zbar B, Ostrander EA. A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd Dog. Hum Mol Genet. Dec 1;12(23):3043-53. doi:10.1093/hmg/ddg336. 2003. [PubMed]
Guyon R, Lorentzen TD, Hitte C, Kim L, Cadieu E, Parker HG, Quignon P, Lowe JK, Renier C, Gelfenbeyn B, Vignaux F, DeFrance HB, Gloux S, Mahairas GG, André C, Galibert F, Ostrander EA. A 1-Mb resolution radiation hybrid map of the canine genome. Proc Natl Acad Sci U S A. Apr 29;100(9):5296-301. doi:10.1073/pnas.0831002100. 2003. [PubMed]
Fleming MA, Potter JD, Ramirez CJ, Ostrander GK, Ostrander EA. Understanding missense mutations in the BRCA1 gene: an evolutionary approach. Proc Natl Acad Sci U S A. Feb 4;100(3):1151-6. doi:10.1073/pnas.0237285100. 2003. [PubMed]
Jónasdóttir TJ, Mellersh CS, Moe L, Heggebø R, Gamlem H, Ostrander EA, Lingaas F. Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs. Proc Natl Acad Sci U S A. Apr 11;97(8):4132-7. doi:10.1073/pnas.070053397. 2000. [PubMed]
Malone KE, Daling JR, Thompson JD, O'Brien CA, Francisco LV, Ostrander EA. BRCA1 mutations and breast cancer in the general population: Analyses in women before age 35 years and in women before age 45 years with first-degree family history. J Am Med Assoc. Mar 25;279(12):922-9. doi:10.1001/jama.279.12.922. 1998. [PubMed]
Mellersh CS, Langston AA, Acland GM, Fleming MA, Ray K, Wiegand NA, Francisco LV, Gibbs M, Aguirre GD, Ostrander EA. A linkage map of the canine genome. Genomics. Dec 15;46(3):326-36. doi:10.1006/geno.1997.5098. 1997. [PubMed]
Langston AA, Malone KE, Thompson JD, Daling JR, Ostrander EA. BRCA1 mutations in a population-based sample of young women with breast cancer. N Engl J Med. Jan 18;334(3):137-42. doi:10.1056/NEJM199601183340301. 1996. [PubMed]