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Settara C. Chandrasekharappa, Ph.D.

Associate Investigator, Cancer Genetics and Comparative Genomics Branch
Head, Cancer Genomics Unit
Head, Genomics Core

Selected Publications

Chandrasekharappa SC, Rebelsky MS, Firak TA, Le Beau MM, Westbrook CA. A long-range restriction map of the interleukin-4 and interleukin-5 linkage group on chromosome 5. Genomics, 6(1):94-9. 1990. [PubMed]
Mercer JF, Livingston J, Hall B, Paynter JA, Begy C, Chandrasekharappa S, Lockhart P, Grimes A, Bhave M, Siemieniak D, et al. Isolation of a partial candidate gene for Menkes disease by positional cloning. Nat Genet, 3(1):20-5. 1993. [PubMed]
Chandrasekharappa S.C., Guru S.C., Manickam P., Olufemi S.E., Collins F.S., Emmert-Buck M.R., Debelenko L.V., Zhuang Z., Lubensky I.A., Liotta L.A., Crabtree J.S., Wang Y., Roe B.A., Weisemann J., Boguski M.S., Agarwal S.K., Kester M.B., Kim Y.S., Heppner C., Dong Q., Spiegel A.M., Burns A.L., Marx S.J. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science, 276:404-407. 1997. [PubMed]

Oda T., Elkahloun A.G., Pike B.L., Okajima K., Krantz I.D., Gennin A., Piccoli D.A., Meltzer P.S., Spinner N.B., Collins F.S., Chandrasekharappa S.C. Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet, 16:235-242. 1997. [PubMed]

Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science, 276(5321):2045-7. 1997. [PubMed]

Guru S.C., Goldsmith P.K., Burns A.L., Marx S.J., Spiegel A.M., Collins F.S., Chandrasekharappa S.C. Menin, the product of the MEN1 gene, is a nuclear protein. Proc Natl Acad Sci U S A, 95:1630-4. 1998. [PubMed]

Debelenko LV, Emmert-Buck MR, Manickam P, Kester M, Guru SC, DiFranco EM, Olufemi SE, Agarwal S, Lubensky IA, Zhuang Z, Burns AL, Spiegel AM, Liotta LA, Collins FS, Marx SJ, Chandrasekharappa SC. Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene. Cancer Res,  57(6):1039-42. 1997. [PubMed]

Guru SC, Olufemi SE, Manickam P, Cummings C, Gieser LM, Pike BL, Bittner ML, Jiang Y, Chinault AC, Nowak NJ, Brzozowska A, Crabtree JS, Wang Y, Roe BA, Weisemann JM, Boguski MS, Agarwal SK, Burns AL, Spiegel AM, Marx SJ, Flejter WL, de Jong PJ, Collins FS, Chandrasekharappa SC. A 2.8-Mb clone contig of the multiple endocrine neoplasia type 1 (MEN1) region at 11q13. Genomics, 42(3):436-45. 1997. [PubMed]

Olufemi SE, Green JS, Manickam P, Guru SC, Agarwal SK, Kester MB, Dong Q, Burns AL, Spiegel AM, Marx SJ, Collins FS, Chandrasekharappa SC. Common ancestral mutation in the MEN1 gene is likely responsible for the prolactinoma variant of MEN1 (MEN1Burin) in four kindreds from Newfoundland. Hum Mutat, 11(4):264-9. 1998. [PubMed]

Chandrasekharappa SC, Teh BT. Clinical and molecular aspects of multiple endocrine neoplasia type 1. Front Horm Res, 28:50-80. 2001. [PubMed]

Itoh, M., Kim, C.H., Palardy, G., Oda, T., Jiang, Y.J., Maust, D., Yeo, S-Y., Lorick, K., Kenworthy, A., Lippincott-Schwartz, J., Weissman, A.M., Lewis, J., Chandrasekharappa, S.C. and Chitnis, A.B. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Developmental Cell, 4:67-8. 2003. [PubMed]
Rodriguez, V., Chen, Y., Elkahloun, A., Dutra, A., Pak, E., Chandrasekharappa, S. Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer. Genes Chromosomes and Cancer, 46:694-707. 2007. [PubMed]

Camps J, Grade M, Nguyen QT, Hormann P, Becker S, Hummon AB, Rodriguez V, Chandrasekharappa S, Chen Y, Difilippantonio MJ, Becker H, Ghadimi BM, Ried T. Chromosomal breakpoints in primary colon cancer cluster at sites of structural variants in the genome. Cancer Res, 68(5):1284-95. 2008. [PubMed]
Novotny E, Compton S, Liu PP, Collins FS, Chandrasekharappa SC. In vitro hematopoietic differentiation of mouse embryonic stem cells requires the tumor suppressor menin and is mediated by Hoxa9. Mech Dev, 126(7):517-22. 2009. [PubMed]
Birkeland AC, Auerbach AD, Sanborn E, Parashar B, Kuhel WI, Chandrasekharappa SC, Smogorzewska A, Kutler DI. Postoperative clinical radiosensitivity in patients with fanconi anemia and head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg, 137(9):930-4. 2011. [PubMed]
Rodriguez V, Vasudevan S, Noma A, Carlson BA, Green JE, Suzuki T, Chandrasekharappa SC. Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA. PLoS One, 7(6):e39297. 2012. [PubMed]
Kanungo J, Chandrasekharappa SC. Menin induces endodermal differentiation in aggregated P19 stem cells by modulating the retinoic acid receptors. Mol Cell Biochem, 359(1-2):95-104. 2012. [PubMed]
Markello TC, Carlson-Donohoe H, Sincan M, Adams D, Bodine DM, Farrar JE, Vlachos A, Lipton JM, Auerbach AD, Ostrander EA, Chandrasekharappa SC, Boerkoel CF, Gahl WA. Sensitive quantification of mosaicism using high density SNP arrays and the cumulative distribution function. Mol Genet Metab, 105(4):665-71. 2012. [PubMed]
Chandrasekharappa SC LF, Kimble DC, Kamat A, Teer JK, Donovan FX, Flynn E, Sen S, NISC Comparative Sequencing Program , Thongthip S, Sanborn E, Smogorzewska A, Auerbach AD, Ostrander EA. Massively Parallel Sequencing, ArrayCGH and RNA-Seq Technologies Provide a Comprehensive Molecular Diagnosis of Fanconi Anemia. Blood, 121(22):e138-48. 2013. [PubMed]

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Last Updated: June 23, 2014