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Eric D. Green, M.D., Ph.D.

Director, National Human Genome Research Institute

Selected Publications

Green ED and Olson MV: Chromosomal region of the cystic fibrosis gene in yeast artificial chromosomes: a model for human genome mapping. Science, 250:94-98. 1990. [PubMed]

Bouffard GG, Idol JI, Braden VV, Iyer LM, Cunningham AF, Weintraub LA, Touchman JW, Mohr-Tidwell RM, Peluso DC, Fulton RS, Ueltzen MS, Weissenbach J, Magness CL, and Green ED: A physical map of human chromosome 7: an integrated YAC contig map with average STS spacing of 79 kb. Genome Res, 7:673-692. 1997. [PubMed]

Everett LA, Glaser B, Beck JC, Idol JR, Buchs A, Heyman M, Adawi F, Hazani E, Nassir E, Baxevanis AD, Sheffield VC, and Green ED: Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). Nat Genet, 17:411-422. 1997. [PubMed]

Mouse Genome Sequencing Consortium: Initial sequencing and comparative analysis of the mouse genome. Nature, 420:520-562. 2002. [PubMed]

Mammalian Gene Collection (MGC) Program Team: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci USA, 99:16899-16903. 2002. [PubMed]

Collins FS, Green ED, Guttmacher AE, and Guyer MS: A vision for the future of genomics research: a blueprint for the genomic era. Nature, 422:835-847. 2003. [PubMed]

Antonellis A., Ellsworth R.E., Sambuughin N., Puls I., Abel A., Lee-Lin S-Q., Jordanova A., Kremensky I., Christodoulou K., Middleton L.T., Sivakumar K., Ionasescu V., Funalot B., Vance J.M., Goldfarb L.G., Fischbeck K.H., and Green E.D. Glycyl tRNA synthetade mutations in Charcot-Marie-Tooth Disease type 2D and distal spinal muscular atrophy type V. Am J Hum Genet, 72:1293-1299. 2003. [PubMed]

Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, VanBrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam A-M, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang S-P, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, and Wilson RK: The DNA sequence of human chromosome 7. Nature, 424:157-164. 2003. [PubMed]

Thomas JW, Touchman JW, Blakesley RW, Bouffard GG, Beckstrom-Sternberg SM, Margulies EH, Blanchette M, Siepel AC, Thomas PJ, McDowell JC, Maskeri B, Hansen NF, Schwartz MS, Weber RJ, Kent WJ, Karolchik D, Bruen TC, Bevan R, Cutler DJ, Schwartz S, Elnitski L, Idol JR, Prasad AB, Lee-Lin S-Q, Maduro VVB, Summers TJ, Portnoy ME, Dietrich NL, Akhter N, Ayele K, Benjamin B, Cariaga K, Brinkley CP, Brooks SY, Granite S, Guan X, Gupta J, Haghighi P, Ho S-L, Huang MC, Karlins E, Laric PL, Legaspi R, Lim MJ, Maduro QL, Masiello CA, Mastrian SD, McCloskey JC, Pearson R, Stantripop S, Tiongson EE, Tran JT, Tsurgeon C, Vogt JL, Walker MA, Wetherby KD, Wiggins LS, Young AC, Zhang L-H, Osoegawa K, Zhu B, Zhao B, Shu CL, De Jong PJ, Lawrence CE, Smit AF, Chakravarti A, Haussler C, Green P, Miller W, and Green ED. Comparative analyses of multi-species sequences from targeted genomic regions. Nature, 424:788-793. 2003. [PubMed]

Margulies E.H., Blanchette M., NISC Comparative Sequencing Program, Haussler D., and Green E.D.. Identification and characterization of multi-species conserved sequences. Genome Research, 14:673-678. 2003. [PubMed]

The ENCODE Project Consortium: The ENCODE (ENCyclopedia Of DNA Elements) Project. Science, 306(5696):636-40. 2002. [PubMed]

The MGC Project Team: The status, quality, and expansion of the NIH full-length cDNA project: The Mammalian Gene Collection (MGC). Genome Res, 14:2121-2127. 2004. [PubMed]

Blakesley R.W., Hansen N.F., Mullikin J.C., Thomas P.J., McDowell J.C., Maskeri B., Young A.C., Benjamin B., Brooks S.Y., Coleman B.I., Gupta J., Ho S-L., Karlins E.M., Maduro Q.L., Stantripop S., Tsurgeon C., Vogt J.L., Walker M.A., Masiello C.A., Guan X., NISC Comparative Sequencing Program, Bouffard G.G., Green E.D. An intermediate grade of finished genomic sequence suitable for comparative analyses. Genome Research, 14:2235-2244. 2004. [PubMed]

Margulies EH, NISC Comparative Sequencing Program, Maduro VVB, Thomas PJ, Tomkins JP, Amemiya CT, Luo M, and Green ED: Comparative sequencing provides insights about the structure and conservation of marsupial and monotreme genomes. Proc Natl Acad Sci USA, 102:3354-3359. 2005. [PubMed]

Schueler, M.G., Dunn, J.M., Bird, C.P., Ross, M.T., Viggiano, L., NISC Comparative Sequencing Program, Rocchi, M., Willard, H.F., and Green, E.D. Progressive proximal expansion of the primate X chromosome centromere. Proc Natl Acad Sci USA. 102:10563-10568. 2005. [PubMed]

Hurle B, Swanson W, NISC Comparative Sequencing Program, and Green ED: Comparative sequence analyses reveal rapid and divergent evolutionary changes of the WFDC locus in the primate lineage. Genome Res, 17:276-286. 2007. [PubMed]

The ENCODE Project Consortium: Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature, 447:799-816. 2007. [PubMed]

Margulies EH, Cooper GM, Asimenos G, Thomas DJ, Dewey CN, Siepel A, Birney E, Keefe D, Schwartz AS, Hou M, Taylor J, Nikolaev S, Montoya-Burgos JI, Loytynoja A, Whelen S, Pardi F, Massingham T, Brown JB, Bickel P, Holmes I, Mullikin JC, Ureta-Vidal A, Paten B, Stone EA, Rosenbloom KR, Kent WJ, NISC Comparative Sequencing Program, Bayor College of Medicine Human Genome Sequencing Center, Washington University Genome Sequencing Center, Broad Institute, UCSC Genome Brower Team, British Columbia Cancer Agency Genome Sciences Center, Antonarakis SE, Batzoglou S, Goldman N, Hardison R, Haussler D, Miller W, Pachter L, Green ED, and Sidow A: Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome. Genome Res, 17:760-774. 2007. [PubMed]

Prasad AB, Allard MW, NISC Comparative Sequencing Program, Green ED. Confirming the phylogeny of mammals by use of large comparative sequence data sets. Mol Biol Evol, 25:1795-1808. 2008. [PubMed]

Tsipouri V, Schueler MG, Hu S, NISC Comparative Sequencing Program, Dutra A, Pak E, Riethman H, Green ED. Comparative sequence analyses reveal sites of ancestral chromosomal fusions in the Indian muntjac genome. Genome Biol, 9:R155. 2008. [PubMed]

Dennis MY, Paracchini S, Scerri TS, Prokunina-Olsson L, Knight JC, Wade-Martins R, Coggill P, Beck S, Green ED, Monaco AP. A common variant associated with dyslexia reduces expression of the KIAA0319 gene. PLoS Genet, 5:e1000436. 2009. [PubMed]

Biesecker LG, Mullikin JC, Facio FM, Turner C, Cherukuri PF, Blakesley RW, Bouffard GG, Chines PS, Cruz P, Green ED. The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res, 19:1665-1674. 2009. [PubMed]

Toronto International Data Release Workshop Authors: Prepublication data sharing. Nature, 461:168-170. 2009. [PubMed]

MGC Project Team: The completion of the Mammalian Gene Collection (MGC). Genome Res, 19:2324-2333. 2009. [PubMed]

Genome 10K Community of Scientists: Genome 10K: a proposal to obtain whole-genome sequence for 10,000 vertebrate species. J Hered, 100:659-674. 2009. [PubMed]

Blakesley RW, Hansen NF, Gupta J, McDowell JC, Maskeri B, Barnabas BB, Brooks SY, Coleman H, Haghighi P, Ho S-L, Schandler K, Stantripop S, Vogt JL, Thomas PJ, NISC Comparative Sequencing Program, Bouffard GG, and Green ED: Effort required to finish shotgun-generated genome sequences differs significantly among vertebrates. BMC Genomics, 11:21. 2010. [PubMed]

Schueler MG, Swanson W, Thomas PJ, NISC Comparative Sequencing Program, and Green ED: Adaptive evolution of foundation kinetochore proteins in primates. Mol Biol Evol, 27:1585-1597. 2010. [PubMed]

Chodroff RA, Goodstadt L, Sirey TM, Oliver PL, Davies KE, Green ED, Molnár Z, and Ponting CP: Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes. Genome Biol, 11:R72. 2010. [PubMed]

Andres AM, Dennis MY, Kretzschmar WW, Cannons JL, Lee-Lin S-Q, Hurle B, NISC Comparative Sequencing Program, Schwartzberg PL, Williamson SH, Bustamante CD, Nielsen R, Clark AG, and Green ED: Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genet, 6:e1001157. 2010. [PubMed]

The 1000 Genomes Project Consortium: A map of human genome variation from population-scale sequencing. Nature, 467:1061-1073. 2010. [PubMed]

Hurle B, Marques-Bonet T, Antonacci F, Hughes I, Ryan JF, NISC Comparative Sequencing Program, Eichler EE, Ornitz DM, and Green ED: Lineage-specific evolution of the vertebrate Otopetrin gene family revealed by comparative genomic analyses. BMC Evol Biol, 11:23. 2011. [PubMed]

Green ED, Guyer MS, and National Human Genome Research Institute: Charting a course for genomic medicine from base pairs to bedside. Nature, 470:204-213. 2011. [PubMed]

The ENCODE Project Consortium: A user's guide to the Encyclopedia of DNA Elements (ENCODE). PLoS Biol, 9:e1001046. 2011. [PubMed]

Feero WG and Green ED: Genomics education for health care professionals in the 21st century. JAMA, 306(9):989-90. 2011. [PubMed]

Manolio TA and Green ED: Genomics reaches the clinic: from basic discoveries to clinical impact. Cell, 147:14-16. 2011. [PubMed]

Lindblad-Toh K, Garber M, Zuk O, Lin MF, Parker BJ, Washietl S, Kheradpour P, Ernst J, Jordan G, Mauceli E, Ward LD, Lowe CB, Holloway AK, Clamp M, Gnerre S, Alföldi J, Beal K, Chang J, Clawson H, Cuff J, Di Palma F, Fitzgerald S, Flicek P, Guttman M, Hubisz MJ, Jaffe DB, Jungreis I, Kent WJ, Kostka D, Lara M, Martins AL, Massingham T, Moltke I, Raney BJ, Rasmussen MD, Robinson J, Stark A, Vilella AJ, Wen J, Xie X, Zody MC, Broad Institute Sequencing Platform and Whole Genome Assembly Team, Baldwin J, Bloom T, Chin CW, Heiman D, Nicol R, Nusbaum C, Young S, Wilkinson J, Worley KC, Kovar CL, Muzny DM, Gibbs RA, Baylor College of Medicine Human Genome Sequencing Center Sequencing Team, Cree A, Dihn HH, Fowler G, Jhangiani S, Joshi V, Lee S, Lewis LR, Nazareth LV, Okwuonu G, Santibanez J, Warren WC, Mardis ER, Weinstock GM, Wilson RK, Genome Institute at Washington University, Delehaunty K, Dooling D, Fronik C, Fulton L, Fulton B, Graves T, Minx P, Sodergren E, Birney E, Margulies EH, Herrero J, Green ED, Haussler D, Siepel A, Goldman N, Pollard KS, Pedersen JS, Lander ES, and Kellis M: A high-resolution map of human evolutionary constraint using 29 mammals. Nature, 478:476-482. 2011. [PubMed]

Teer JK, Green ED, Mullikin JC, and Biesecker LG: VarSifter: visualizing and analyzing exome-scale sequence variation data on a desktop computer. Bioinformatics, 28:599-600. 2012. [PubMed]

McBride CM, Bryan AD, Bray MS, Swan GE, and Green ED. Health behavior change: can genomics improve behavioral adherence? Am J Public Health, 102:401-405. 2012. [PubMed]

The ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature, 489:57-74. 2012. [PubMed]

The 1000 Genomes Project Consortium. An integrated map of genetic variation from 1,092 human genomes. Nature, 491:56-65. 2012. [PubMed]

Marques PI, Bernardino R, Fernandes T, NISC Comparative Sequencing Program, Green ED, Hurle B, Quesada V, and Seixas S: Birth-and-death of KLK3 and KLK2 in primates: evolution driven by reproductive biology. Genome Biol Evol. 4:1331-1338. 2012. [PubMed]

Prasad AB, Mullikin JC, NISC Comparative Sequencing Program, and Green ED. A scalable and flexible approach for investigating the genomic landscapes of phylogenetic incongruence. Mol Phylogenet Evol, 66:1067-1074. 2013. [PubMed]

Rodriguez LL, Brooks, LD, Greenberg JH, and Green ED. The complexities of genomic identifiability. Science, 339:275-276. 2013. [PubMed]

Calzone KA, Jenkins J, Nicol N, Skirton H, Feero WG, and Green ED. Relevance of genomics to healthcare and nursing practice. J Nurs Scholarsh, 45:1-2. 2013. [PubMed]

Manolio TA, Chisholm RL, Ozenberger B, Roden DM, Williams MS, Wilson R, Bick D, Bottinger EP, Brilliant MH, Eng C, Frazer KA, Korf B, Ledbetter DH, Lupski JR, Marsh C, Mrazek D, Murray MF, O'Donnell PH, Rader DJ, Relling MV, Shuldiner AR, Valle D, Weinshilboum R, Green ED, and Ginsburg GS. Implementing genomic medicine in the clinic: the future is here. Genet Med, 15:258-267. 2013. [PubMed]

Ferreira Z, Seixas S, Andrés AM, Kretzschmar WW, Mullikin JC, Cherukuri PF, Cruz P, Swanson WJ, NISC Comparative Sequencing Program, Clark AG, Green ED, and Hurle B. Reproduction and immunity-driven natural selection in the human WFDC locus. Mol Biol Evol, 30:938-950. 2013. [PubMed]

Lonsdale J, Thomas J, Salvatore M, Phillips R, Lo E, Shad S, Hasz R, Walters G, Garcia F, Young N, Foster B, Moser M, Karasik E, Gillard B, Ramsey K, Sullivan S, Bridge J, Magazine H, Syron J, Fleming J, Siminoff L, Traino H, Mosavel M, Barker L, Jewell S, Rohrer D, Maxim D, Filkins D, Harbach P, Cortadillo E, Berghuis B, Turner L, Hudson E, Feenstra K, Sobin L, Robb J, Branton P, Korzeniewski G, Shive C, Tabor D, Qi L, Groch K, Nampally S, Buia S, Zimmerman A, Smith A, Burges R, Robinson K, Valentino K, Bradbury D, Cosentino M, Diaz-Mayoral N, Kennedy M, Engel T, Williams P, Erickson K, Ardlie K, Winckler W, Getz G, Deluca D, Macarthur D, Kellis M, Thomson A, Young T, Gelfand E, Donovan M, Meng Y, Grant G, Mash D, Marcus Y, Basile M, Liu J, Zhu J, Tu Z, Cox NJ, Nicolae DL, Gamazon ER, Im HK, Konkashbaev A, Pritchard J, Stevens M, Flutre T, Wen X, Dermitzakis ET, Lappalainen T, Guigo R, Monlong J, Sammeth M, Koller D, Battle A, Mostafavi S, McCarthy M, Rivas M, Maller J, Rusyn I, Nobel A, Wright F, Shabalin A, Feolo M, Sharopova N, Sturcke A, Paschal J, Anderson JM, Wilder EL, Derr LK, Green ED, Struewing JP, Temple G, Volpi S, Boyer JT, Thomson EJ, Guyer MS, Ng C, Abdallah A, Colantuoni D, Insel TR, Koester SE, Little AR, Bender PK, Lehner T, Yao Y, Compton CC, Vaught JB, Sawyer S, Lockhart NC, Demchok J, and Moore HF. The Genotype-Tissue Expression (GTEx) project. Nat Genet, 45:580-585. 2013. [PubMed]

Ferreira Z, Hurle B, Andrés AM, Kretzschmar WW, Mullikin JC, Cherukuri PF, Cruz P, Gonder MK, Stone AC, Tishkoff S, Swanson WJ, NISC Comparative Sequencing Program, Green ED, Clark AG, and Seixas S: Sequence diversity of Pan troglodytes subspecies and the impact of WFDC6 selective constraints in reproductive immunity. Genome Biol Evol, 5:2512-2523. 2013. [PubMed]

Manolio TA and Green ED. Leading the way to genomic medicine. Am J Med Genet C Semin Med Genet, 166C:1-7. 2014. [PubMed]

Ramos EM, Din-Lovinescu C, Berg JS, Brooks LD, Duncanson A, Dunn M, Good P, Hubbard TJ, Jarvik GP, O'Donnell C, Sherry ST, Aronson N, Biesecker LG, Blumberg B, Calonge N, Colhoun HM, Epstein RS, Flicek P, Gordon ES, Green ED, Green RC, Hurles M, Kawamoto K, Knaus W, Ledbetter DH, Levy HP, Lyon E, Maglott D, McLeod HL, Rahman N, Randhawa G, Wicklund C, Manolio TA, Chisholm RL, and Williams MS: Characterizing genetic variants for clinical action. Am J Med Genet C Semin Med Genet, 166C:93-104. 2014. [PubMed]

Sen SK, Barb JJ, Cherukuri PF, Accame DS, Elkahloun AG, Singh LN, Lee-Lin SQ, NISC Comparative Sequencing Program, Kolodgie FD, Cheng Q, Zhao X, Chen MY, Arai AE, Green ED, Mullikin JC, Munson PJ, and Biesecker LG: Identification of candidate genes involved in coronary artery calcification by transcriptome sequencing of cell lines. BMC Genomics, 15:198. 2014.[PubMed]

Kellis M, Wold B, Snyder MP, Bernstein BE, Kundaje A, Marinov GK, Ward LD, Birney E, Crawford GE, Dekker J, Dunham I, Elnitski LL, Farnham PJ, Feingold EA, Gerstein M, Giddings MC, Gilbert DM, Gingeras TR, Green ED, Guigo R, Hubbard T, Kent J, Lieb JD, Myers RM, Pazin MJ, Ren B, Stamatoyannopoulos JA, Weng Z, White KP, and Hardison RC: Defining functional DNA elements in the human genome. Proc Natl Acad Sci USA, 111:6131-6138. 2014.[PubMed]

Kapoor A, Sekar RB, Hansen NF, Fox-Talbot K, Morley M, Pihur V, Chatterjee S, Brandimarto J, Moravec CS, Pulit SL, QT Interval-International GWAS Consortium, Pfeufer A, Mullikin J, Ross M, Green ED, Bentley D, Newton-Cheh C, Boerwinkle E, Tomaselli GF, Cappola TP, Arking DE, Halushka MK, and Chakravarti A: An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval. Am J Hum Genet 94:854-869, 2014. PMID: 24857694 [PMCID: PMC4121472]

H3Africa Consortium. Research capacity. Enabling the genomic revolution in Africa. Science, 344:1346-1348. 2014. [PubMed]

Sen SK, Boelte KC, Barb JJ, Joehanes R, Zhao X, Cheng Q, Adams L, Teer JK, Accame DS, Chowdhury S, Singh LN, NISC Comparative Sequencing Program, CHARGE Consortium, Kavousi M, Peyser PA, Quigley L, Priel DL, Lau K, Kuhns DB, Yoshimura T, Johnson AD, Hwang SJ, Chen MY, Arai AE, Green ED, Mullikin JC, Kolodgie FD, O'Donnell CJ, Virmani R, Munson PJ, McVicar DW, and Biesecker LG: Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification. Am J Hum Genet, 95:66-76. 2014.[PubMed]

Margolis R, Derr L, Dunn M, Huerta M, Larkin J, Sheehan J, Guyer M, and Green ED. The National Institutes of Health's Big Data to Knowledge (BD2K) initiative: capitalizing on biomedical big data. J Am Med Inform Assoc, 21:957-958. 2014. [PubMed]

Paltoo DN, Rodriguez LL, Feolo M, Gillanders E, Ramos EM, Rutter JL, Sherry S, Wang VO, Bailey A, Baker R, Caulder M, Harris EL, Langlais K, Leeds H, Luetkemeier E, Paine T, Roomian T, Tryka K, Patterson A, and Green ED for the National Institutes of Health Genomic Data Sharing Governance Committees. Data use under the NIH GWAS Data Sharing Policy and future directions. Nat Genet, 46:934-938. 2014. [PubMed]

Kellis M, Wold B, Snyder MP, Bernstein BE, Kundaje A, Marinov GK, Ward LD, Birney E, Crawford GE, Dekker J, Dunham I, Elnitski LL, Farnham PJ, Feingold EA, Gerstein M, Giddings MC, Gilbert DM, Gingeras TR, Green ED, Guigo R, Hubbard T, Kent J, Lieb JD, Myers RM, Pazin MJ, Ren B, Stamatoyannopoulos J,Weng Z, White KP, and Hardison RC: Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease. Proc Natl Acad Sci USA, 111:E3366. 2014. [PubMed]

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Last Updated: November 12, 2014