Chimpanzee Genome Sequencing

In early 2002, the National Human Genome Research Institute (NHGRI) agreed to support a chimpanzee genome sequencing project initially aimed at producing 6- to 8-fold, whole genome shotgun sequence coverage of the chimpanzee (Pan troglodytes) genome. A short time later, in late 2003, a decision was made to support a proposal to complete a high-quality (6- to 8-fold coverage) genome assembly. Paired end reads from plasmids, fosmids, and BACs will be assembled and the assembly will be analyzed before a decision is made to continue sequencing to a greater depth of coverage.

The chimpanzee genome sequencing project is led by the Broad Institute/MIT Center for Genome Research and the Washington University Genome Sequencing Center.

Genome Sequencing Whitepaper Proposal:

• Pan troglodytes
  (Submitted Feb. 2002)
   
• Pan troglodytes
  (Submitted Oct. 2002)

Project Link:

• Washington University Genome Sequencing Center [genome.wustl.edu]

Supporting Institutions:

• Broad Institute [broadinstitute.org]

Additional Resources

Sequence and Assembly

• Individual Sequence Reads:
  • NCBI Trace Archive [ncbi.nlm.nih.gov]

ESTs

• dbEST [ncbi.nlm.nih.gov]- Database of ESTs at NCBI

SNPs

• dbSNP [ncbi.nlm.nih.gov]- Database of Single Nucleotide Polymorphisms at NCBI

BAC Libraries

• Children's Hospital Oakland Research Institute (CHORI) - Chimpanzee BAC libraries:
  • CHORI-251 Chimpanzee BAC library [bacpac.chori.org]
  • RPCI - 43 Male Chimpanzee BAC Library [bacpac.chori.org]
  • CHORI-1251: Chimpanzee Fosmid Library [bacpac.chori.org]