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Chemistry and Biology: Partners in
Decoding the Genome

March 15-16, 2004
8:30 a.m. - 5:00 p.m.


Monday, March 15, 2004

8:30 - 8:45 a.m. Welcome: Elias Zerhouni, Director, National Institutes of Health
8:45 - 8:50 a.m. Greetings from Sponsoring Institutes:
Jeremy Berg, Director, National Institute of General Medical Sciences
  Moderator: John Schwab
National Institute of General Medical Sciences
8:50 - 9:15 a.m. Christopher Austin, National Human Genome Research Institute
Small Molecules and the NIH Roadmap
9:15 - 9:55 a.m. Daniel Kahne, Princeton University
Glycopeptide Antibiotics and Cell Envelope Biogenesis
9:55 - 10:35 a.m. Stuart Schreiber, Harvard University
Dissecting Disease Biology and Advancing Medicine with Small Molecules
10:35 - 10:50 a.m. Break
10:50 - 11:30 a.m. Craig Crews, Yale University
A Small Molecule Approach to Target Identification and Validation
11:30 - 12:10 p.m Carolyn Bertozzi, University of California, Berkeley
Chemical Approaches to Studying Protein Glycosylation
12:10 - 1:00 p.m. Lunch
Moderator: Christopher Austin
National Human Genome Research Institute
1:00 - 1:40 p.m. David Liu, Harvard University
An Evolution-Based Approach to the Creation and Discovery of Functional Synthetic Molecules
1:40 - 2:20 p.m. Roger Tsien, University of California, San Diego
Genetically and Proteolytically Targeted Sequences for Imaging from Ultrastructure to Whole Mammals
2:20 - 3:00 p.m. Jeremy Berg, Director, National Institute of General Medical Sciences
Chemical Approaches to Zinc Finger Protein Analysis and Design
3:00 - 3:20 p.m. Break
3:20 - 4:00 p.m. Jon Ellman, University of California, Berkeley
Combinatorial Chemistry Targeting Protein Families
4:00 - 4:40 p.m. Gary Glick, University of Michigan
Chemistry and Biology of Immunosuppressive Benzodiazepines
4:40-5:20 p.m. Stephen Fesik, Abbott Laboratories
NMR-Based Screening of Fragment Libraries for Drug Discovery

Tuesday, March 16, 2004

  Moderator: John Beutler
National Cancer Institute
8:30 - 9:15 a.m. Kevan Shokat, University of California, San Francisco
Chemical Tools for Deciphering Cell Signaling Pathways
9:15 - 10:00 a.m. David Diller, Pharmacopeia
The Role of Computation When Building
Collections of Millions of Compounds
10:00 - 10:45 a.m. Virginia Cornish, Columbia
Co-opting Nature for Chemical Diversity
10:45 - 11:15 a.m. Break
11:15 - 12:00 p.m. DimitriusAgrafiotis, 3-Dimensional Pharmaceuticals
Molecular Informatics for the New Drug Discovery Enterprise
12:00 - 1:00 p.m. Lunch
  Moderator: Carole Bewley, National Institute of Diabetes and
Digestive and Kidney Diseases
1:00 - 1:40 p.m Chaitan Khosla, Stanford University
Discovery and Development of New Natural Product Drugs:
The Example of Polyketides
1:40 - 2:20 p.m. Baldomero Olivera,University of Utah Conus Peptides: From Genes to Venoms to Drugs
2:20 - 3:00 p.m. Michael Organ, York University
New Advances in the Screening of Compound Mixtures
3:00 - 3:20 p.m. Break
3:20 - 4:00 p.m. Alan Verkman, University of California, San Francisco
Drug Discovery in Academia: CFTR Chloride Channel Inhibitors and Activators for Cystic Fibrosis
4:00 - 4:40 p.m. Eric Lander, The Broad Institute of MIT and Harvard
4:40 - 5:00 p.m. Closing Remarks:
Alan Guttmacher, Deputy Director, National Institute of General Medical Sciences

Last updated: May 23, 2012