The Human Genome Project officialy began in 1990. Beginning in December 1984, the U.S. Department of Energy (DOE), National Institutes of Health (NIH) and international groups had sponsored meetings to consider the feasibility and usefulness of mapping and sequencing the human genome. The DOE had become interested in studying the human genome as a way of aiding the detection of mutations that nuclear radiation might cause. Groups like the NIH and the Wellcome Trust in Britain had longstanding interest in understanding biology for the sake of advancing medicine.
In 1987, DOE proposed a Human Genome Initiative to Congress. Meanwhile, NIH had started funding occasional grants for genome projects. In 1988, an influential National Research Council report recommended a concerted program to map and sequence the human genome. Later that year, the U.S. Congress held hearings on the idea, and DOE and NIH joined forces on the project.
In 1990, DOE and NIH published a plan for the first five years of what was projected to be a 15-year project. The goals of the project included: mapping the human genome and eventually determining the sequence of all 3.2 billion letters in it; mapping and sequencing the genomes of other organisms important to the study of biology; developing technology for analyzing DNA; and studying the ethical, legal and social implications of genome research.
Watson, J.D., Jordan, E. The Human Genome Program at the National Institutes of Health. Genomics, 5: 654-56. 1989. [PubMed]
1. Map and sequence the human genome
2. Map and sequence the genomes of model organisms
(The approximate number of base pairs in each species' genome is given in parentheses.)
3. Collect and distribute data
4. Study the ethical, legal and social implications of genetic research
5. Train researchers
6. Develop technologies
7. Transfer technology to the private sector
Last Reviewed: May 6 2013