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ENCODE: Guidebook to the Human Genome

ENCODE Project Background Resources


After a multi-year concerted effort by more than 440 researchers in 32 labs around the world, researchers have produced a more dynamic picture of the human genome that gives the first holistic view of how the human genome actually does its job.

During the new study, researchers linked more than 80 percent of the human genome sequence to a specific biological function and mapped more than 4 million regulatory regions where proteins specifically interact with the DNA. These findings represent a significant advance in understanding the precise and complex controls over the expression of genetic information within a cell.

The findings are reported in two papers appearing in the Sept. 5 online issue of Nature. Read the series of coordinated scientific reports published in Nature: www.nature.com/encode

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Last updated: September 07, 2012