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The National Human Genome Research Institute's (NHGRI) Initial Review Group (IRG) provides first-level peer review of grant applications. The review committee, called the Genome Research Review Committee (GNOM-G), meets three times a year.

Application Review Details

Applications reviewed by the IRG Genome Research Review Committee include but are not limited to:

  • Special projects for constructing genetic and physical maps
  • Determining DNA sequences
  • Developing methods for analysis of genomic DNA including computational approaches
  • Developing innovative technologies
  • Developing and maintaining tools and resources such as genome databases
  • Supporting training and career development opportunities and workshops and conferences in genome research

NHGRI provides a second level of review by the National Advisory Council for Human Genome Research.

The majority of investigator-initiated grant applications related to genomics research (e.g. R01) are reviewed by National Institutes of Health (NIH) Initial Review Groups organized by the NIH Center for Scientific Review.

  • Application Review Details

    Applications reviewed by the IRG Genome Research Review Committee include but are not limited to:

    • Special projects for constructing genetic and physical maps
    • Determining DNA sequences
    • Developing methods for analysis of genomic DNA including computational approaches
    • Developing innovative technologies
    • Developing and maintaining tools and resources such as genome databases
    • Supporting training and career development opportunities and workshops and conferences in genome research

    NHGRI provides a second level of review by the National Advisory Council for Human Genome Research.

    The majority of investigator-initiated grant applications related to genomics research (e.g. R01) are reviewed by National Institutes of Health (NIH) Initial Review Groups organized by the NIH Center for Scientific Review.

Group Charter

The Secretary of Health and Human Services (Secretary) is mandated under Section 301 of the Public Health Service (PHS) Act, as amended (42 U.S.C. 241), to support through grants, cooperative agreements, and contracts, research relating to human genome research. In addition, the Secretary is authorized under Section 487 of the PHS Act, as amended (42 U.S.C. 288), to support research and research training through National Research Service Awards.

The National Human Genome Research Institute Initial Review Group (Initial Review Group) reviews grant and cooperative agreement applications and contract proposals for research projects and for research and training activities in areas relevant to the Human Genome Project, including construction of genetic maps, development of physical maps, determination of DNA sequences, management and analysis of the resulting data, development of innovative technologies required to achieve these goals, and development of tools and resources supportive of this effort, as well as in areas relevant to the ethical, legal, and social implications of the Human Genome Project.

Authority

42 U.S.C. 282(b)(6), Section 402(b)(6) of the PHS Act, as amended. The Initial Review Group is governed by the provisions of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), which sets forth standards for the formation and use of advisory committees.

Function

The Initial Review Group shall advise the Director, National Institutes of Health (NIH), and the Director, National Human Genome Research Institute (NHGRI), on the scientific and technical merit of applications for grants-in-aid for research, research training, or research-related grants and cooperative agreements, or contract proposals relating to scientific areas relevant to the Human Genome Project, including construction of genetic maps, development of physical maps, determination of DNA sequences, management and analysis of the resulting data, development of innovative technologies required to achieve these goals, and development of tools and resources supportive of this effort, as well as applications and proposals that address the ethical, legal, and social implications of the Human Genome Project.

The members shall survey, as scientific leaders, the status of research and research training in their fields.

As necessary, the Initial Review Group and its subcommittees may seek advice from special consultants.

Structure

Members, the Chair, and the Chairs of the subcommittees shall be selected by the Director, NIH, from authorities knowledgeable in the various disciplines and fields of cytogenetics, human genetics, quantitative genetics, somatic cell genetics, molecular biology, cell biology, chemistry, biochemistry, physical biochemistry, computer science, engineering, bioethics, law, public policy, medical genetics, genetic counseling, nursing, education, and public outreach.

Members shall be invited to serve for overlapping terms of up to four years; the term for a member who is to serve as Chair may include a fifth year.

As necessary, standing and ad hoc subcommittees of the Initial Review Group, composed of members from the parent committee, may be established to perform specific functions within the Initial Review Group's jurisdiction. The Department Committee Management Officer shall be notified upon establishment of each standing subcommittee and shall be provided information on its name, membership, function, and estimated frequency of meetings.

The Chairs of each subcommittee may be designated as Cochairs for the Initial Review Group as a whole and upon approval by the subcommittee Chair, the advice of the subcommittee shall be considered the advice of the Committee.

A member of one subcommittee may serve as a voting member of other subcommittees when that member's expertise is required. However, that member shall not be counted in determining the presence of a quorum.

The permanent membership of the Initial Review Group may be supplemented at any meeting through temporary members who, because of their scientific expertise, are appointed to review some or all of the applications considered at that meeting. Notification to the prospective temporary members from the Designated Federal Official that the individual is to attend the meeting shall constitute a temporary appointment to the committee for purposes of that meeting, and the individual shall have all the rights and obligations of committee membership at that meeting, including the right to vote on recommendations in which the individual fully participated as a reviewer. Temporary members will be included in the tracking of reviewers with respect to geographical distribution and ethnic and gender representation to ensure that appropriate balance of members' perspectives may be maintained. Temporary members shall not count toward a quorum.

A quorum for the conduct of business by the full Initial Review Group is five members. A quorum for each subcommittee shall be five members.

Management and support services shall be provided by Office of Scientific Review, NHGRI.

Meetings

The full Initial Review Group shall meet in plenary session, as necessary, as called by the Chair with advance approval of a Government official, who shall approve the agenda. Meetings of the subcommittees shall be held approximately three times per year at the call of the Chair, with the advance approval of a Government official who shall also approve the agenda. A Government official shall be present at all meetings of the Initial Review Group and of the subcommittees.

Meetings shall be open to the public unless determined otherwise by the Secretary; notice of all meetings shall be given to the public.

Meetings shall be conducted and records of the proceedings kept as required by applicable laws and departmental policies.

Compensation

Members shall be paid at the rate of $200 per day, plus per diem and travel expenses in accordance with Standard Government Travel Regulations. Members who are officers or employees of the United States shall not receive compensation for service on the Initial Review Group.

Annual Cost Estimate

The estimated annual cost for operating the Initial Review Group, including compensation and travel expenses for members but excluding staff support is $77,304. The estimate of annual person-years of staff support required is 0.8, at an estimated annual cost of $60,293.

Reports

In the event a portion of a meeting is closed to the public, a report shall be prepared which shall contain, as a minimum, a list of members and their business addresses, the Initial Review Group's functions, dates, and places of meetings, and a summary of Initial Review Group activities and recommendations made during the fiscal year. A copy of the report shall be provided to the Department Committee Management Officer.

Establishment Date

July 1, 1990

Termination Date

Continuing

  • Group Charter

    The Secretary of Health and Human Services (Secretary) is mandated under Section 301 of the Public Health Service (PHS) Act, as amended (42 U.S.C. 241), to support through grants, cooperative agreements, and contracts, research relating to human genome research. In addition, the Secretary is authorized under Section 487 of the PHS Act, as amended (42 U.S.C. 288), to support research and research training through National Research Service Awards.

    The National Human Genome Research Institute Initial Review Group (Initial Review Group) reviews grant and cooperative agreement applications and contract proposals for research projects and for research and training activities in areas relevant to the Human Genome Project, including construction of genetic maps, development of physical maps, determination of DNA sequences, management and analysis of the resulting data, development of innovative technologies required to achieve these goals, and development of tools and resources supportive of this effort, as well as in areas relevant to the ethical, legal, and social implications of the Human Genome Project.

    Authority

    42 U.S.C. 282(b)(6), Section 402(b)(6) of the PHS Act, as amended. The Initial Review Group is governed by the provisions of the Federal Advisory Committee Act, as amended (5 U.S.C. Appendix 2), which sets forth standards for the formation and use of advisory committees.

    Function

    The Initial Review Group shall advise the Director, National Institutes of Health (NIH), and the Director, National Human Genome Research Institute (NHGRI), on the scientific and technical merit of applications for grants-in-aid for research, research training, or research-related grants and cooperative agreements, or contract proposals relating to scientific areas relevant to the Human Genome Project, including construction of genetic maps, development of physical maps, determination of DNA sequences, management and analysis of the resulting data, development of innovative technologies required to achieve these goals, and development of tools and resources supportive of this effort, as well as applications and proposals that address the ethical, legal, and social implications of the Human Genome Project.

    The members shall survey, as scientific leaders, the status of research and research training in their fields.

    As necessary, the Initial Review Group and its subcommittees may seek advice from special consultants.

    Structure

    Members, the Chair, and the Chairs of the subcommittees shall be selected by the Director, NIH, from authorities knowledgeable in the various disciplines and fields of cytogenetics, human genetics, quantitative genetics, somatic cell genetics, molecular biology, cell biology, chemistry, biochemistry, physical biochemistry, computer science, engineering, bioethics, law, public policy, medical genetics, genetic counseling, nursing, education, and public outreach.

    Members shall be invited to serve for overlapping terms of up to four years; the term for a member who is to serve as Chair may include a fifth year.

    As necessary, standing and ad hoc subcommittees of the Initial Review Group, composed of members from the parent committee, may be established to perform specific functions within the Initial Review Group's jurisdiction. The Department Committee Management Officer shall be notified upon establishment of each standing subcommittee and shall be provided information on its name, membership, function, and estimated frequency of meetings.

    The Chairs of each subcommittee may be designated as Cochairs for the Initial Review Group as a whole and upon approval by the subcommittee Chair, the advice of the subcommittee shall be considered the advice of the Committee.

    A member of one subcommittee may serve as a voting member of other subcommittees when that member's expertise is required. However, that member shall not be counted in determining the presence of a quorum.

    The permanent membership of the Initial Review Group may be supplemented at any meeting through temporary members who, because of their scientific expertise, are appointed to review some or all of the applications considered at that meeting. Notification to the prospective temporary members from the Designated Federal Official that the individual is to attend the meeting shall constitute a temporary appointment to the committee for purposes of that meeting, and the individual shall have all the rights and obligations of committee membership at that meeting, including the right to vote on recommendations in which the individual fully participated as a reviewer. Temporary members will be included in the tracking of reviewers with respect to geographical distribution and ethnic and gender representation to ensure that appropriate balance of members' perspectives may be maintained. Temporary members shall not count toward a quorum.

    A quorum for the conduct of business by the full Initial Review Group is five members. A quorum for each subcommittee shall be five members.

    Management and support services shall be provided by Office of Scientific Review, NHGRI.

    Meetings

    The full Initial Review Group shall meet in plenary session, as necessary, as called by the Chair with advance approval of a Government official, who shall approve the agenda. Meetings of the subcommittees shall be held approximately three times per year at the call of the Chair, with the advance approval of a Government official who shall also approve the agenda. A Government official shall be present at all meetings of the Initial Review Group and of the subcommittees.

    Meetings shall be open to the public unless determined otherwise by the Secretary; notice of all meetings shall be given to the public.

    Meetings shall be conducted and records of the proceedings kept as required by applicable laws and departmental policies.

    Compensation

    Members shall be paid at the rate of $200 per day, plus per diem and travel expenses in accordance with Standard Government Travel Regulations. Members who are officers or employees of the United States shall not receive compensation for service on the Initial Review Group.

    Annual Cost Estimate

    The estimated annual cost for operating the Initial Review Group, including compensation and travel expenses for members but excluding staff support is $77,304. The estimate of annual person-years of staff support required is 0.8, at an estimated annual cost of $60,293.

    Reports

    In the event a portion of a meeting is closed to the public, a report shall be prepared which shall contain, as a minimum, a list of members and their business addresses, the Initial Review Group's functions, dates, and places of meetings, and a summary of Initial Review Group activities and recommendations made during the fiscal year. A copy of the report shall be provided to the Department Committee Management Officer.

    Establishment Date

    July 1, 1990

    Termination Date

    Continuing

Roster

The National Human Genome Research Institute Initial Review Group has one committee, the Genome Research Review Committee (GNOM-G), which conducts the review of a wide variety of grant proposals to evaluate their scientific and technical merit. The term expiration date is in parentheses.

Chair

Nickerson, Deborah A., Ph.D. (6/30/2013)
Professor
Department of Genomes Sciences
University of Washington
Seattle, WA 98195-5065

Members

Bult, Carol J., Ph.D. (6/30/2014)
Professor
Bioinformatics and Computational Biology
The Jackson Laboratory
Bar Harbor, ME 04609

Carpten, John D., Ph.D. (06/01/2015)
Senior Investigator
Division of Integrated Cancer Genomics
Translational Genomics Research Institute
Phoenix, AZ 85004

Crawford, Dana C., Ph.D. (6/30/2014)
Assistant Professor
Center for Human Genetics Research
Vanderbilt University Medical Center
Nashville, TN 37232

Frazer, Kelly A., Ph.D. (6/30/2012)
Professor
Department of Pediatrics
University of Californa, San Diego
School of Medicine
La Jolla, CA 92093-0901

Gingeras, Thomas R., Ph.D. (6/30/2014)
Professor
Department of Functional Genomics
Cold Spring Harbor Laboratories
Cold Spring Harbor, NY 11724

Kwok, Pui-Yan M.D., Ph.D. (6/30/2012)
Professor
Department of Dermatology
University of California, San Francisco
San Franciso, CA 94143

Rosenberg, Noah, Ph.D. (6/30/2013)
Associate Professor
Departments of Human Genetics, Biostatistics, and Ecology and Evolutionary
Center for Computational Medicine & Bioinformatics
University of Michigan
Ann Arbor, MI 48109

Sutton, Granger G., Ph.D. (06/01/2015)
Professor
Director of Informatics
J. Craig Venter Institute
Rockville, MD

Scientific Review Administrators

Mckenney, Keith H., Ph.D.
Scientific Review Branch
National Human Genome Research Institute
National Institutes Of Health
Bethesda, MD 20892

Nakamura, Ken D., Ph.D.
Scientific Review Branch
National Human Genome Research Institute
National Institutes of Health
Bethesda, MD 20892

Pozzatti, Rudy O., Ph.D.
Scientific Review Branch
National Human Genome Research Institute
National Institutes Of Health
Bethesda, MD 20892

  • Roster

    The National Human Genome Research Institute Initial Review Group has one committee, the Genome Research Review Committee (GNOM-G), which conducts the review of a wide variety of grant proposals to evaluate their scientific and technical merit. The term expiration date is in parentheses.

    Chair

    Nickerson, Deborah A., Ph.D. (6/30/2013)
    Professor
    Department of Genomes Sciences
    University of Washington
    Seattle, WA 98195-5065

    Members

    Bult, Carol J., Ph.D. (6/30/2014)
    Professor
    Bioinformatics and Computational Biology
    The Jackson Laboratory
    Bar Harbor, ME 04609

    Carpten, John D., Ph.D. (06/01/2015)
    Senior Investigator
    Division of Integrated Cancer Genomics
    Translational Genomics Research Institute
    Phoenix, AZ 85004

    Crawford, Dana C., Ph.D. (6/30/2014)
    Assistant Professor
    Center for Human Genetics Research
    Vanderbilt University Medical Center
    Nashville, TN 37232

    Frazer, Kelly A., Ph.D. (6/30/2012)
    Professor
    Department of Pediatrics
    University of Californa, San Diego
    School of Medicine
    La Jolla, CA 92093-0901

    Gingeras, Thomas R., Ph.D. (6/30/2014)
    Professor
    Department of Functional Genomics
    Cold Spring Harbor Laboratories
    Cold Spring Harbor, NY 11724

    Kwok, Pui-Yan M.D., Ph.D. (6/30/2012)
    Professor
    Department of Dermatology
    University of California, San Francisco
    San Franciso, CA 94143

    Rosenberg, Noah, Ph.D. (6/30/2013)
    Associate Professor
    Departments of Human Genetics, Biostatistics, and Ecology and Evolutionary
    Center for Computational Medicine & Bioinformatics
    University of Michigan
    Ann Arbor, MI 48109

    Sutton, Granger G., Ph.D. (06/01/2015)
    Professor
    Director of Informatics
    J. Craig Venter Institute
    Rockville, MD

    Scientific Review Administrators

    Mckenney, Keith H., Ph.D.
    Scientific Review Branch
    National Human Genome Research Institute
    National Institutes Of Health
    Bethesda, MD 20892

    Nakamura, Ken D., Ph.D.
    Scientific Review Branch
    National Human Genome Research Institute
    National Institutes of Health
    Bethesda, MD 20892

    Pozzatti, Rudy O., Ph.D.
    Scientific Review Branch
    National Human Genome Research Institute
    National Institutes Of Health
    Bethesda, MD 20892

Last updated: March 19, 2012