NHGRI logo

2020 Advanced Genomic Technology Development Meeting

Event Details

The National Human Genome Research Institute (NHGRI) hosted the virtual Advanced Genomic Technology Development Meeting, on May 27-29, 2020. The purpose of the virtual meeting series is to provide an open forum to discuss key scientific and technical challenges faced with advanced sequencing and genomic technologies. The meeting will bring together NHGRI Genomic Technology Program grantees, other scientists, and engineers who have insights that could synergistically help to develop a broad suite of novel methods. Activities are designed to update fellow grantees and NHGRI about progress in the field and specific funded projects, facilitate collaborations, and provide a forum that effectively serves the entire set of participants, who range from grant investigators to trainees.



Virtual Meeting Agenda

  • Wednesday, May 27, 2020

  • 11:00 a.m. Introduction
  • 11:05 a.m. Highlighting Grantee COVID-19 Work
    Moderator: Avtar Singh
  • Genomics & SARS-CoV-2: The Seattle Experience
    Jay Shendure
  • Towards understanding COVID-19 infection, transmission & pathogenesis at single cell resolution with the Human Cell Atlas
    Aviv Regev
  • Fighting SARS-2 with optical pooled genomic screening and multiplexed viral diagnostics
    Paul Blainey
  • Mapping and targeting protein-protein interaction interfaces
    Prashant Mali
  • Nucleotide analogues as inhibitors of SARS-CoV-2 polymerase, a key drug target for COVID-19
    Jingyue Ju
  • 12:20 p.m. Panel Discussion
    COVID Speakers
  • 12:40 p.m. Break
  • 1:00 p.m. NHGRI and Technology Development Program Updates
  • 1:15 p.m. Grantee Talks
    Moderator: Kristin Gabriel
  • Improving strategies to reach high-quality telomere-to-telomere assemblies of human genomes
    Karen Miga
  • Towards high accuracy nanopore sequencing
    Jens Gundlach
  • 1:55 p.m. Break
  • 2:00 p.m. Trainee Discussion: Establishing and improving scientific collaborations
    Panelists: Eric Ervin, Peter Smibert, Chongyuan Luo
  • 2:30 p.m. End Day 1


  • Thursday, May 28, 2020

  • 11:00 a.m. Trainee Talks
    Moderator: Andrew Laszlo
  • In vivo Perturb-seq: Study gene function at scale
    Xin Jin (Zhang)
  • Massively multiplexed chromatin accessibility profiling within single cells
    Gregory Booth (Trapnell)
  • Mapping the 5-hydroxymethylome at single base and single cell resolution with bisulfite-assisted, APOBEC-coupled epigenetic sequencing (bACE-Seq)
    Emily Fabyanic (Kohli)
  • Exploring the nascent transcriptome by nanopore analysis of CO-transcriptional processing
    Karine Choquet (Churchman)
  • Lifetime and stability of silicon nitride nanopores and nanopore arrays for ionic measurements
    Yung-Chien Chou (Drndic)
  • Computational design engine for accurate and efficient sequencing of DNA and RNA
    Jyoti Mahalik (Muthukumar)
  • 12:00 p.m. Break
  • 12:20 p.m. Grantee Talks
    Moderator: Fatemeh Farhangdoust
  • Sensitive spatial genome wide expression profiling at cellular resolution
    Fei Chen
  • Spatio-genetic imaging with DNA microscopy
    Joshua Weinstein (Regev)
  • Unambiguous identification of novel human transcript isoforms using nanopore direct mRNA sequencing
    Mark Akeson
  • Direct nanopore detection of modified RNA to probe structure and dynamics
    Winston Timp
  • 1:40 p.m. Break
  • 1:45 p.m. Trainee Discussion: Fostering open data sharing and exchange
    Panelists: Karen Miga, Paul Blainey
  • 2:15 p.m. End Day 2


  • Friday, May 29, 2020

  • 11:00 a.m. Grantee Talks
    Moderator: Kian Hong Kock
  • Single cell multi-omic profiling of 3D genome organization and DNA methylation
    Jesse Dixon (Ecker)
  • A transposase system for integrative ChIP-exo and ATAC-seq analysis
    Julia Zeitlinger
  • Single cell and single molecule detection of epigenetic modifications
    Brad Bernstein
  • High throughput joint profiling of chromatin accessibility and protein levels in single cells
    Eleni Mimitou (Smibert)
  • 12:20 p.m. Break
  • 12:40 p.m. Grantee Talks
    Moderator: Jakob Buchheim
  • DNA/RNA SMRT sequencing using electro-optical waveguides
    Meni Wanunu
  • Single molecule dynamics of Taq DNA polymerase at 72°C
    Phil Collins
  • Engineered polymerase for electrical readout of enzyme activity
    Stuart Lindsay
  • 1:40 p.m. Break
    Mackenzie Turvey
  • 1:45 p.m. Trainee Discussion: Funding your next career steps
    Panelists: Fei Chen, Julia Zeitlinger, Lisa Chadwick
  • 2:15 p.m. End of Meeting

Last updated: July 13, 2021