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NHGRI Division of Intramural Research Seminar Series

Event Details

The Division of Intramural Research (DIR) sponsors a monthly series of talks by intramural and special guest speakers celebrating genetics and genomics research. Speakers are selected by NHGRI intramural faculty and trainees and cover research topics of interest to a wide audience.

All seminars are free and open to the public. Seminar titles and other details are updated as information becomes available.

For more information, please contact Dr. Shawn Burgess at burgess@mail.nih.gov.

Upcoming Seminars

Past Seminars

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Recorded Videos

Upcoming Seminars

Understanding genetic variants: from technology development to the clinic

February 23, 2023, 2:00 - 3:00 p.m. ET

Douglas Fowler

Douglas M. Fowler, Ph.D.
Associate Professor
Department of Genome Sciences
University of Washington

Speaker Biography: The Fowler lab is interested in how mutations impact protein function. Protein-coding mutations are important because they underlie many diseases (e.g. cancer).. Furthermore, studying the consequences of mutagenesis can reveal biochemical properties of proteins. Finally, point mutations are the smallest unit of change in protein sequence during evolution. Recently, we developed deep mutational scanning, a method that uses high-throughput DNA sequencing to characterize the functional consequences of large numbers (10^5-10^6) of mutations in a protein simultaneously. Currently, we are using deep mutational scanning to establish a large-scale genotype-phenotype map for cancer related proteins and to study protein aggregation.

Hosts: Meru Sadhu and Michael Chambers

Follow @dougfowler42 on Twitter

March 23, 2023, 2:00 - 3:00 p.m. ET

Christina Cuomo, Ph.D.
Group Leader, Fungal Genomics Group
Associate Director, Genomic Center for Infectious Diseases
Broad Institute of MIT and Harvard

Follow @christina_cuomo on Twitter

April 20, 2023, 2:00 - 3:00 p.m. ET

John M. Greally, Ph.D., D.Med., M.B.,B.Ch., B.A.O.
Professor, Department of Genetics
Professor, Department of Pediatrics (Pediatric Genetic Medicine)
Chief, Department of Genetics Division of Genomics
Albert Einstein College of Medicine

Follow @greally on Twitter

May 4, 2023, 2:00 - 3:00 p.m. ET

Rasmus Nielsen, Ph.D.
Professor, Department of Integrative Biology
University of California, Berkeley

Follow @ras_nielsen on Twitter

June 22, 2023, 2:00 - 3:00 p.m.

Harmit Malik, Ph.D.
Professor and Associate Director
Basic Sciences Division
Fred Hutchinson Cancer Center

Follow @HarmitMalik on Twitter

September 21, 2023, 2:00 - 3:00 p.m. ET

Brittany Adamson, Ph.D.
Assistant Professor, Department of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics
Princeton University

Follow @bsadamson on Twitter

Past Seminars

The Biology of Health Disparities: Ancestry-Driven Drug Discovery

October 6, 2022, 2:00 - 3:00 p.m. ET

K. Sean Kimbro

K. Sean Kimbro, Ph.D.
Professor, Department of Biomedical and Biological Sciences
Director, Integrated Bioscience Ph.D. Program
JLC Biomedical Biotechnology Research Institute
North Carolina Central University

Hosts: Shawn Burgess and Ariel Williams

* Co-hosted by the Genomics and Health Disparities Lecture Series

Ancestry and diseases in Latin American populations

November 3, 2022, 2:00 - 3:00 p.m. ET

Eduardo Tarazona-Santos

Eduardo Tarazona-Santos, Ph.D.
Professor, Department of Genetics, Ecology and Evolution
Institute of Biological Sciences
Federal University of Minas Gerais

Speaker Biography:  My research focuses on the genetics of Indigenous and admixed Latin American populations. I lead the Laboratory of Human Genetic Diversity at the Federal University of Minas Gerais, which focuses on three areas: (i) the role of genomic diversity of Indigenous and admixed Latin American populations in the genetic architecture of complex diseases and drug response; (ii) inferences about the Pre-Columbian demographic history of Native American populations and the dynamics of Post-Columbian admixture in the Americas using genetic data; and (iii) the development of new concepts and tools in computational biology to study human genetic diversity. We are involved in the EPIGEN-Brazil Project, a major initiative at the interface of human genomics, epidemiology of complex diseases, and computational biology. I also lead the genomics and bioinformatics aspect of a project with a cohort of over 10,000 elderly Brazilian individuals. Recently, my group has initiated the Mosaico Translational Genomics project, which uses a transdisciplinary approach to integrate concepts of computational biology, genomics, medicine, and public health in global precision and evidence-based medicine.

Hosts: Charles Rotimi and Mateus Gouveia

Follow @tarazona_santos on Twitter

Phylomapping: the use of nature’s experiments to understand the genetic regulation of diversity, development and disease

December 15, 2022, 2:00 - 3:00 p.m. ET

Matthew Harris, Ph.D.

Matthew Harris, Ph.D.
Associate Professor of Genetics
Harvard Medical School

Speaker Biography: My research leverages forward genetic as well as genomic approaches to understand developmental processes that potentiate growth and patterning in late development. My lab’s work combines analysis of mutants identified in zebrafish and comparative genomics in a broad expanse of other fishes exhibiting unique phenotypes. These approaches have proven to be powerful in modeling developmental and genetic causes of both evolutionary change and human skeletal disorders. Our work has provided a foundation for the use of fish as experimental models and comparative genomics to understand the genetic regulation of development and disease. Current research program focuses on the regulation of proportional growth, bioelectric regulation of development and regeneration, as well as stem cell maintenance in aging.

Hosts: Shawn Burgess and Luis Colon-Cruz

Follow @fishyskeleton on Twitter

Mechanisms of CRISPR-mediated immunity and applications beyond editing

January 5, 2023, 2:00 - 3:00 p.m. ET

Blake Wiedenheft

Blake Wiedenheft, Ph.D.
Professor, Microbiology and Immunology; Biotechnology
Montana State University

Speaker Biography: Viruses that infect bacteria (i.e., bacteriophages) are the most abundant biological entities on earth, and the selective pressures that these pervasive predators impose have a profound impact on the composition and behavior of microbial communities in every ecological setting. Work in the Wiedenheft laboratory aims to understand the mechanisms that bacteria use to defend themselves from phage infection and counter mechanisms that phages use to subvert bacterial immune systems. We aim to determine the molecular structures of the cellular machines that mediate bacterial immunity, and we aim to use these structures to understand function. The scientific culture in the Wiedenheft lab is to understand and engineer cellular machines with new functions for applications in biotechnology and medicine.

Hosts: Julie Segre and Amanda Fuchs

Follow @WiedenheftLab on Twitter

Request an Accommodation

This event will be presented with real-time captioning. American Sign Language interpreting services are available upon request. Individuals who need interpreting services and/or other reasonable accommodations to participate in this event should contact Britny Kish at britny.kish@nih.gov or the NIH Interpreting Office directly at nih@ainterpreting.com. Requests should be made at least five business days in advance in order to ensure interpreter availability.

Last updated: January 26, 2023