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Genomic Medicine XIV: Genomic Learning Healthcare Systems

Event Details

On August 31 - September 1, 2022, the National Human Genome Research Institute (NHGRI) sponsored its 14th Genomic Medicine meeting, Genomic Medicine XIV: Genomic Learning Healthcare Systems.  

This meeting discussed progress and identify generalizable solutions to the challenges of implementing genomic medicine we have encountered since the 2015 National Academy of Medicine's Genomics-Enabled Learning Health Care Systems workshop. Persistent barriers and evidence gaps were examined as opportunities for additional research.

The objectives of the meeting were to:

  • Explore real-world examples of how genomic learning healthcare systems (gLHS) apply cycles of genomic medicine implementation, evaluation, adjustment and updated implementation practices across delivery systems.
  • Examine barriers and identify potential solutions, with a focus on lessons learned from effective gLHS and their potential transportability to other settings.
  • Determine ways to develop and share solutions and form collaborations to facilitate research on implementing gLHS.

Meeting Booklet (PDF)

Executive Summary (PDF)

Meeting Summary (PDF)

Genomic Medicine Working Group Discussion on Genomic Medicine XIV (PDF)



Recorded Video

Wednesday, August 31, 2022

Time Topic Speaker(s)

11:00 a.m.

Welcome and Introductions



Overview of National Academy of Medicine's 2015 Workshop, Genomics-Enabled Learning Health Care Systems

Pat Deverka


Structure, Goals and Products of NHGRI Genomic Medicine Meetings

Teri Manolio

11:15 a.m.

Session 1: Laying the Groundwork

Rex Chisholm
Renee Rider


Keynote: The State of Genomic Learning Healthcare Systems (25 min)

Peter Hulick


Overview of gLHS Barriers (10 min)

Teri Manolio


Panel Discussion (55 min)

Adam Buchanan
Gai Elhanan
Casey Overby-Taylor
Bruce Korf

12:45 p.m.



12:55 p.m.

Session 2: IT Infrastructure

Carol Bult
Christopher Chute


Clinical Informatics Recommendations From GM XIII (15 min)

Ken Wiley


Integrating Genomic Results Into EHRs (15 min)

Travis Osterman


Population-Based Clinical Decision Support for Precision Medicine (15 min)

Guilherme Del Fiol


Discussion (45 min)

2:25 p.m.


2:55 p.m.

Session 3: The Role of gLHS in Increasing Health Equity and Access to Genomic Healthcare

Gail Jarvik
Karriem Watson


Identifying Biases in gLHS Data and Implementation (15 min)

Janina Jeff
Latrice Landry



Diverse Patient and Provider Engagement in gLHS (15 min)

Carol Horowitz


Facilitating gLHS through Patient Access to Genomic Information (15 min)

Deven McGraw


Discussion (60 min)

4:55 p.m.

Adjourn Day 1



Thursday, September 1, 2022

Time Topic Speaker(s)

11:00 a.m.




Day 1 Recap

Pat Deverka
Teri Manolio

11:10 a.m.

Session 4: Enabling Providers to Implement Genomic Knowledge

Susanne Haga
Robb Rowley


Genomic Medicine Track for Internal Medicine Trainees (15 min)

Noura Abul-Husn


Improving Access to Genomics in Clinical Practice (15 min)

Rizwan Hamid


Scalable Solutions for Genetic Counseling (15 min)

Cynthia A. James


Genomic Medicine Implementation in the VA Healthcare System (15 min)

Jason Vassy


Discussion (45 min)

1:10 p.m.


1:30 p.m.

Session 5: Establishing and Sustaining gLHS

Erin Ramos
Krystal Tsosie


Generating Evidence of Effectiveness and Value (15 min)

Howard McLeod


Genomic Learning Healthcare Systems and Payers (15 min)

Nancy Mendelsohn


Progress in the Integration of Personalized Medicine and Developing Common Metrics (15 min)

Daryl Pritchard


Discussion (45 min)


3:00 p.m.



3:10 p.m.

Session 6: Realizing the Promise of gLHS

Pat Deverka
Teri Manolio


Turning gLHS Data into Knowledge (15 min)

Heidi Rehm


Creation of a Virtuous Cycle to Realize the gLHS (15 min)

Marc S. Williams


Scaling the Genomics Enabled Learning Health System to Optimize Research and Clinical Care (15 min)

Geoff Ginsburg


Discussion (30 min)

4:25 p.m.

Summary and Next Steps

Pat Deverka
Teri Manolio

5:00 p.m.

Adjourn Day 2


Last updated: March 6, 2023