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Multi-omics in Health and Disease: Current Applications, Challenges and Future Directions

Event Details

On June 17-18, 2021, NHGRI hosted a workshop, Multi-omics in Health and Disease: Current Applications, Challenges and Future Directions.

The objectives for the workshop were:

  1. To gain insight on how multi-omics data can improve our understanding of health and disease
  2. To identify study design, data integration and technological gaps and challenges to the use of multi-omics technology and its application to observational studies
  3. To define opportunities to overcome these challenges that are relevant to NHGRI’s mission

View the agenda for:

to

All times are in ET.

Day 1: June 17, 2021

1:00 - 1:05 p.m.

Welcome

Howard Chang, Stanford University
Judy Cho, Icahn School of Medicine at Mt. Sinai
Workshop Rationale
Moderator: Howard Chang (Stanford University)

1:05 - 1:15 p.m.

Overview of NHGRI’s Strategic Vision

Eric Green, NHGRI
1:15 - 1:25 p.m. Purpose of Workshop and Agenda overview Joannella Morales, NHGRI
1:25 - 1:35 p.m. Summary of NIH Investments in the Field of Multi-omics Marie-Luise Brennan, NHGRI
1:35 - 1:45 p.m. Q&A

Session 1: Setting the Stage - Application of multi-omics to study health and disease
Moderator: Judy Cho, Icahn School of Medicine at Mt. Sinai

1:45 - 2:15 p.m.

Keynote 1: Multi-omics Integration to Understand Health and Disease

Nancy Cox, Vanderbilt University
2:15 - 2:45 p.m. Keynote 2: Personal Profiling Using Multi-omics Michael Snyder, Stanford University

Session 2: Technology, Data Integration and Study Design
Moderator: Dave Bodine, NHGRI

2:45 - 3:05 p.m.

Presentation 1 - Experimental and Computational Technology / Big Data

Xihong Lin, Harvard University

3:05 - 3:25 p.m.

Presentation 2 - Study Design and Sample Collection

Tuuli Lappalainen, New York Genome Center
3:25 - 3:45 p.m. Presentation 3 - Data Integration Marjorie Brand, Ottawa Hospital Research Institute

3:45 - 4:00 p.m.

Break

Guided Discussion - Technology, Data Integration and Study Design
Moderator: Ajay Pillai, NHGRI

4:00 p.m. - 4:15 p.m.

Each panelist will have 5 mins to answer:

  1. Where do we want to be?
  2. What are the barriers and opportunities?

Panelists:

  • Sarah Teichmann, Wellcome Sanger Institute
  • Lana Garmire, University of Michigan
  • Neil Hanchard, NHGRI
4:15 - 4:45 p.m. Moderated Discussion

4:45 - 5:00 p.m.

Summary of Day 1 and Wrap-up

Day 2: June 18, 2021

1:00 - 1:05 p.m.

Welcome and Agenda Overview

Howard Chang, Stanford University
Judy Cho, Icahn School of Medicine at Mt. Sinai
1:05 - 1:10 p.m. Recap of the Previous Day
Session 3: Application of Multi-omics to Observational Studies
Moderator: Joannella Morales, NHGRI

1:10 - 1:25 p.m.

Presentation 1: Using Polygenic Risk Scores Combined With Multi-omics Data to Provide Insights Into Prodromal Disease and Prevention

Nathan Price, Onegevity and Institute for Systems Biology
1:25 - 1:40 p.m. Presentation 2: Understanding How Multi-omics Tracks Environmental Influences Kari Nadeau, Stanford University
1:40 - 1:55 p.m. Presentation 3: Studying Multi-omics in a Longitudinal Context Corinne Engelman, University of Wisconsin - Madison
1:55 - 2:10 p.m. Presentation 4: Using a Multi-omics Approach to Better Subtype Heterogeneous Patients and Predict Patterns (Progression/Prevention) Tes Mersha, Cincinnati Children’s Hospital

Guided Discussion - Application of Multi-omics to Observational Studies 
Moderator: Jonathan Haines, Case Western Reserve University

2:10 - 2:30 p.m.

Each panelist will have 5 mins to answer:

  1. Where do we want to be?
  2. What are the barriers and opportunities?

Panelists

  • Myriam Fornage, UT Health
  • Adam Butterworth, University of Cambridge
  • Greg Gibson, Georgia Tech
  • Alison Goate, Icahn School of Medicine at Mt. Sinai
2:30 - 2:55 p.m. Moderated Discussion
2:55 - 3:15 p.m. Break

Session 4: Future Clinical implementation: Roadblocks and Opportunities
Moderator: Erin Ramos, NHGRI

3:15 - 3:25 p.m.

Presentation 1: Multi-omics and Therapeutic Interventions

Judy Cho, Icahn School of Medicine at Mt. Sinai

3:25 - 3:35 p.m.

Presentation 2: Perspective/Overview Lessons Learned From Moving Genomics Into the Clinic

David Craig, University of Southern California
3:25 - 4:00 p.m.

Discussion

  • What steps and initiatives would be required to implement multi-omics technologies in the clinic?
  • What are the barriers?
  • How do we ensure generalizability to all populations and promote equity?

3:45 - 4:00 p.m.

Break

Session 5: Recommendations to NHGRI
Moderator: Howard Chang, Stanford University and Judy Cho, Icahn School of Medicine

4:00 p.m. - 5:00 p.m.

  • Summary of Workshop, Key Themes, and Recommendations
  • Discussion

 

Last updated: June 25, 2021