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News Release
NIH Center for Research on Genomics and Global Health is participating in the H3Africa Consortium's effort to develop an African-specific genotyping array.
… Researchers have made a good start in identifying and understanding genetic mutations that have evolved over thousands of years to protect Africans from disease-causing pathogens. Today, these same … comprehensive DNA sampling and genetic characterization of Africans and the people of the African diaspora." Dr. Rotimi …
Educational Resources
A frameshift mutation is a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three.
… Genetic Mutation, Base Pairs, DNA Sequence … in the addition of the wrong amino acids to the protein and/or the creation of a codon that stops the protein from …
Educational Resources
A nonsense mutation is the substitution of a single base pair that leads to the appearance of a stop codon where previously there was a codon specifying an amino acid.
… Nonsense Mutation, Missense Mutation, Base Pair, Genetic Code, Genetic Mutation …
News Release
More research must be done to understand the interactions of ancient genes with modern environments.
… Researchers have made a good start in identifying and understanding genetic mutations that have evolved over thousands of years to protect Africans from disease-causing pathogens. … same mutations can increase the risk of other diseases in Africans and people of African descent. Mutations in the gene …
Educational Resources
A mutation is a change in a DNA sequence. Mutations can result from DNA copying mistakes made during cell division, exposure to ionizing radiation, exposure to chemicals called mutagens, or infection by viruses.
… A mutation is a change in a DNA sequence. Mutations can result from DNA copying mistakes made during … A mutation is a change in the DNA sequence of an organism. Mutations can result from errors in DNA replication during … a viral infection. Germline mutations (that occur in eggs and sperm) can be passed on to offspring, while somatic …
Educational Resources
A point mutation is when a single base pair is altered.
… base pair is added, deleted or changed. While most point mutations are benign, they can also have various functional …
Educational Resources
A missense mutation is when the change of a single base pair causes the substitution of a different amino acid in the resulting protein.
… position in the resulting protein. Some missense mutations alter the function of the resulting protein. …
News Release
Researchers have conducted the first study to look at the genomic underpinnings of obesity in continental Africans and African Americans.
… at the genomic underpinnings of obesity in continental Africans and African Americans. They discovered that approximately 1 percent of West Africans, African Americans and others of African ancestry … to investigate the genomic basis of obesity in continental Africans, said Guanjie Chen, M.D., study co-lead and a CRGGH …
News Release
A new study by scientists at NHGRI, suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning.
… since Japanese researchers Shinya Yamanaka, M.D., Ph.D., and his graduate student Kazutoshi Takahashi, Ph.D., … earliest stage of development (a pluripotent stem cell) and change it into different types of cells in the body. … the vision of those with age-related macular degeneration and other eye diseases, and cardiac cells to restore damaged …
News Release
NIH-backed African scientists are engaged in a global research endeavor to understand the genetic basis of disease in all populations.
… engaged in a global research endeavor to understand the genetic basis of disease in all populations. But this can … have shown that African populations contain the oldest and most diverse set of human genes. However, most studies of … focused on European ancestry populations. By not exploring genetic variation within African populations, opportunities …