Search Results
News Release
Genomic variants that increase risk of kidney disease are found in nearly one-third of West Africans
A study from researchers at National Institutes of Health (NIH) and their collaborators revealed a significant genetic risk factor for kidney disease in people of West African ancestry.
… for earlier health interventions for people with West African ancestry. … Research Network. Previous research established that genomic variants in APOL1 increase the risk of developing chronic kidney disease among African Americans. However, not much is known about how these …
News Release
Two grants will support studies on genomic literacy among Africans relating to research conducted in Africa by African investigators.
… grants totaling more than $300,000 will support studies on genomic literacy among Africans as it relates to research conducted in Africa by African investigators. The three-year grants are part of the … to get a better sense of what people in two different African countries understand about genomics concepts," said …
News Release
In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease.
… ancestral groups substantially improves identification of genomic variants associated with blood lipid levels. … ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood … about 1.65 million individuals from five ancestral groups: African, East Asian, European, Hispanic and South Asian. …
Clinical Research
GENE-FORECAST® is developing a community cohort and resource for defining the significance of ancestry-related genomic variation in African-Americans.
… study is developing a community-based cohort and novel genomic science resource for defining the biological significance of ancestry-related genomic variation in African-Americans. … between the distinct genomic variation characteristic of African-Americans (AA) and the exposome of social …
Research Funding
Polygenic RIsk MEthods in Diverse populations (PRIMED) Consortium will work together to develop and implement approaches to integrating extant genotype and phenotype data for the purpose of conducting and disseminating Consortium-wide PRS analyses.
… Southern California** David Conti*, John Witte Leveraging Diversity in Cancer Epidemiology Cohorts and Novel Methods to … Optimize the integration of large-scale, harmonized genomic and phenotype data.  Starting June 2021, the seven … integration and analysis will occur largely on NHGRI's Genomic Data Science Analysis, Visualization, and Informatics …
News Release
Diverse populations are still underrepresented in public genomic databases, according to a new study by researchers from the NIH and Harvard Medical School.
… Precision medicine will largely be built on vast troves of genomic information, but diverse populations are still underrepresented in public genomic databases, according to a new study by researchers … Databases They found significantly fewer studies of African, Latin American and Asian ancestral populations …
News Release
NIH researchers and collaborators have found that that sickle cell trait is prevalent among diverse human populations.
… trait and blood clots have only included individuals of African genetic ancestry and self-identified Black … carrier state only affects those who identify as Black or African American. While sickle cell trait in the United … trait. People with sickle cell trait have one copy of the genomic variant that causes sickle cell disease, a genetic …
Educational Resources
A gene pool is the total genetic diversity found within a population or a species.
… A gene pool is the total genetic diversity found within a population or a species. … Genetic Diversity, Genes, Extinction, Population Genetics … population or species. A large gene pool has extensive genomic diversity and is better able to withstand environmental …
Educational Resources
Genomic variation refers to diversity in gene frequencies.
… Genomic Variation … Genomic variation refers to diversity in gene frequencies. … Genomic variation refers to DNA sequence differences among … Genomic variation refers to diversity in gene frequencies. …
News Release
NIH will fund grants totaling $38 million over five years to develop methods that will improve the way that polygenic risk scores can be used to predict disease in diverse communities.
… calculate polygenic risk scores by comparing the genomic data of people with and without a particular disease. … populations. The new consortium, called PRIMED , will pool genomic information from existing and new datasets to develop … populations. Researchers have used available large-scale genomic datasets to develop the ability to calculate …