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News Release
Researchers have conducted the first study to look at the genomic underpinnings of obesity in continental Africans and African Americans.
… is the first study to use a Genome-Wide Association Study (GWAS) to investigate the genomic basis of obesity in … Chen, M.D., study co-lead and a CRGGH staff scientist. A GWAS compares the genomes of people with and without a health … the condition. Most previous studies on obesity using a GWAS have been conducted with populations of European …
News Release
Grants are awarded to GTEx project to explore human gene expression and regulation in different tissues, and how genomic variation modulates that expression.
… will analyze DNA and RNA from the samples to identify and catalog genomic variants and gene expression. For the last … scientists have used genome-wide association studies (GWAS) to study the role that genomic variation plays in complex diseases and traits. In GWAS, researchers compare thousands of genomic variants in …
Research Funding
The E​MERGE Network develops, disseminates and applies approaches to research that combine biorepositories with electronic medical record systems.​
… to population of interest Integration of existing GWAS sets PRS reassessment and validation Recruitment, … genomic variation. These genome wide association studies (GWAS) conducted with EMR data helped pave the way for other … using the EMR. From 2011 to 2015, while still conducting GWAS, the Network began returning genomic testing results …
Research at NHGRI
An international investigation into the genetics of severe acute malnutrition in children.
…  Mills, M.C. and Rahal, C., (2020). ‘The GWAS Diversity Monitor tracks diversity by disease in real … heavily to represent individuals of European ancestry ( GWAS Diversity Monitor 2023 ). This lack of diversity fails …
Staff
Heather Colley is a Lead Research Training and Career Development Program Officer at the National Human Genome Research Institute.
… in 2007. Her research portfolio included the NHGRI-EBI GWAS Catalog , PhenX Toolkit , PAGE Consortium , IGNITE … in genomics studies, with application to the NHGRI-EBI GWAS Catalog. Genome Biol . 19(1):21. 2018. [ PubMed ] MacArthur …
Event
On May 19-20, 2016, the National Human Genome Research Institute (NHGRI) hosted a two-day workshop where participants were asked to weigh the benefits and risks of sharing aggregate genomic data with secondary users.
… NIH Background Fact Sheet on GWAS Policy Update Workshop on Establishing a Central …
Staff
Dr. Charles Rotimi is the scientific director of and NIH Distinguished Investigator in the Division of Intramural Research. He also serves as the director of the Center for Research on Genomics and Global Health (CRGGH).
… meta-analysis of 17 genome-wide association studies (GWAS) for T2D in over 8,000 cases and 16,000 controls. … (data generation is complete and analysis is ongoing), (2) GWAS of 1,200 cases and 1,200 controls from West Africa using … pharmacogenomically-relevant gene variants by mining the 1000 Genomes database and conducting de novo genotyping using …
Research at NHGRI
NHGRI researchers develop freely available software and analysis tools to help researchers around the world analyze and explore their genomic data.
… Selection for Genome-Wide Association Studies (ComPaSS-GWAS) An ad-hoc alternative to replication that can reduce …
The Genomics Landscape
In May 4, 2023 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., details a report released by the National Academies of Science, Engineering, and Medicine, that provided a series of recommendations for using population descriptors in future genetics and genomics studies.
…  The NHGRI-EBI GWAS Catalog is celebrating its 15th birthday this year. The … the number of published genome-wide association studies (GWAS). These studies provide an unprecedented opportunity to … NHGRI-EBI GWAS Catalog turns 15 …
News Release
An international team of researchers including NIH has completed the first comprehensive characterization of genomic diversity across sub-Saharan Africa.
… a modest number of genome-wide association studies, or GWAS, using continental African populations, while thousands … their research information to the available data from the 1000 Genomes Project for subsequent analyses. The 1000 … public-private consortium producing an extensive catalog of human genomic variation as a resource for medical …