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Research at NHGRI
The NHGRI Cancer Genetics and Comparative Genomics Branch identifies and study genes that contribute to cancer susceptibility and progression.
… The Cancer Genetics and Comparative Genomics Branch seeks to identify and study genes that contribute to cancer susceptibility and progression. … and somatic (body cell) mutations that contribute to cancer susceptibility syndromes and to the development of … also study the relationship between genetic variation and cancer progression and pursue the discovery of both inherited …
Talking Glossary
El cáncer es una enfermedad en la que algunas células del cuerpo crecen fuera de control. Hay muchos tipos diferentes de cáncer, y cada uno comienza cuando una única célula adquiere un cambio genómico (o mutación) que le permite dividirse y multiplicarse sin control.
Media Availability
The Cancer Genome Atlas identified molecular subtypes to help clinicians determine which tumors are more aggressive and which will respond to treatment.
… thyroid carcinomas (PTC) - the most common form of thyroid cancer - has provided new insights into the roles of frequently mutated cancer genes and other genomic alterations that drive disease … WHAT: Investigators with The Cancer Genome Atlas (TCGA) Research Network identified new …
Genetic Disorders
Colon cancer is a malignant tumor of the large intestine that affects both men and women.
… Colon cancer, a malignant tumor of the large intestine, affects … States, approximately 160,000 new cases of colorectal cancer are diagnosed each year. … Colon cancer, a malignant tumor of the large intestine, affects … States, approximately 160,000 new cases of colorectal cancer are diagnosed each year. The majority of colon cancer …
News Release
Receiving a cancer diagnosis can feel like losing control of everything.
… Receiving a cancer diagnosis can feel like losing control of everything. … its natural defenses, which can then lead to diseases like cancer," said Laura Elnitski, Ph.D., a senior investigator in the Translational and Functional Genomics Branch at the National Human Genome Research …
News Release
NIH-funded researchers completed the PanCancer Atlas from over 10,000 tumors representing 33 types of cancer.
… from over 10,000 tumors representing 33 types of cancer. … Francis S. Collins, M.D., Ph.D. "This analysis provides cancer researchers with unprecedented understanding of how, … Human Genome Research Institute (NHGRI): NHGRI leads genomics research at the National Institutes of Health (NIH), …
Research Funding
Effort to accelerate understanding of the molecular basis of cancer using genome analysis technologies, including large-scale genome sequencing.
… The Cancer Genome Atlas (TCGA) was a joint effort of the National Cancer Institute (NCI) and the National Human Genome Research … More information on TCGA can be found on NCI’s The Cancer Genome Atlas Program website . The Cancer Genome Atlas … NIH completes in-depth genomic analysis of 33 cancer types  (2018)  The Cancer Genome Atlas publishes …
Genetic Disorders
Prostate cancer is a disease where certain cells in the prostate become abnormal and multiply to form a tumor.
… Prostate cancer is the most common cancer in American men aside from skin cancer. One in 6 American men will develop prostate cancer … Age: A man's age is the strongest risk factor for prostate cancer. It is rare for a man to develop prostate cancer before the age of 40. After age 50 the chance of …
News Release
Researchers are trying to understand a process whose rules are constantly being written and rewritten by cancer's rogue cells: who will more likely relapse.
… For a patient with cancer, two of the most important words in the oncologist's … hear the word remission - meaning both their symptoms and cancer are abating. Some may even get to full remission - no detectable cancer. But, unfortunately, some patients will hear the word …
News Release
A the largest genomics study of clear cell endometrial cancer (CCEC) tumors has identified mutations in the TAF1 gene.
… In the largest genomics study of clear cell endometrial cancer (CCEC) tumors … tumors are sometimes similar to other types of uterine cancer, namely serous endometrial cancers or endometrioid … Largest Study of Its Kind Endometrial cancer is the most commonly diagnosed gynecological cancer …