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News Release
In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease.
… In a large-scale study of people from diverse ancestries, … major risk factor for heart disease. The study, published in the journal Nature , was led by the Global Lipids … risk for such diseases.” Since the field’s inception, the genomics community has performed over 6,000 studies looking …
News Release
An international team of researchers including NIH has completed the first comprehensive characterization of genomic diversity across sub-Saharan Africa.
… the first comprehensive characterization of genomic diversity across sub-Saharan Africa. The region is the most genetically diverse in the world, yet few studies have looked into genomic risk factors for disease in Africa. … that makes each individual unique. "The rich genomic diversity in sub-Saharan African populations can offer new …
News Release
Diverse populations are still underrepresented in public genomic databases, according to a new study by researchers from the NIH and Harvard Medical School.
… but diverse populations are still underrepresented in public genomic databases, according to a new study by … Diverse Groups Underrepresented in Genomic Databases They found significantly fewer studies … specify inclusion standards or justification for lack of diversity as a requirement for publication. Implementation of …
Talking Glossary
La hibridación in situ es una técnica de laboratorio empleada para localizar una secuencia de ADN o ARN en una muestra biológica.
… Hibridación in situ … La hibridación in situ es una técnica de laboratorio empleada para localizar … La hibridación in situ es una técnica de laboratorio empleada para localizar … La hibridación in situ es una técnica de laboratorio empleada para localizar …
News Release
NHGRI researchers and their collaborators, have successfully used facial analysis software to diagnose Noonan syndrome in Africans, Asians and Latin Americans.
… used facial analysis software to diagnose Noonan syndrome in Africans, Asians and Latin Americans. They announced their findings in the September 2017 issue of the American Journal of … Syndrome is relatively common -- affecting between 1 in 1,000 to 1 in 2,500 children -- few studies have been …
News Release
NIH researchers and collaborators have found that that sickle cell trait is prevalent among diverse human populations.
… backgrounds with sickle cell trait. The study, published in Blood Advances , was led by researchers at National Human … as Black or African American. While sickle cell trait in the United States is most prevalent in individuals who self-identify as Black or African …
Educational Resources
A gene pool is the total genetic diversity found within a population or a species.
… A gene pool is the total genetic diversity found within a population or a species. … Genetic Diversity, Genes, Extinction, Population Genetics … combination of all the genes (including alleles) present in a reproducing population or species. A large gene pool has extensive genomic diversity and is better able to withstand environmental …
Fact Sheets
La hibridación fluorescente in situ brinda a los investigadores una manera de visualizar y mapear el material genético en las células de un individuo.
… La hibridación fluorescente in situ (HFIS) brinda a los investigadores una manera de … hfis.jpg] ¿Qué es la HFIS? La hibridación fluorescente in situ (HFIS) brinda a los investigadores una manera de … Hibridación fluorescente in situ … La hibridación fluorescente in situ brinda a los investigadores una manera de visualizar …
Educational Resources
Genomic variation refers to diversity in gene frequencies.
… Genomic variation refers to diversity in gene frequencies. … Genomic variation refers to diversity in gene frequencies. …
News Release
NIH will fund grants totaling $38 million over five years to develop methods that will improve the way that polygenic risk scores can be used to predict disease in diverse communities.
… that polygenic risk scores can be used to predict disease in diverse communities. Polygenic risk scores, often referred … European ancestry populations, are not effective when used in diverse populations. The new consortium, called PRIMED , … started to allow clinicians to use polygenic risk scores in combination with a person’s lifestyle and environmental …