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Talking Glossary
Un locus, en relación con la genómica, es un sitio o ubicación fÃsicos en un genoma (como un gen u otro segmento de ADN de interés), algo asà como una dirección.
… Locus … Un locus, en relación con la genómica, es un sitio o ubicación … Un locus, en relación con la genómica, es un sitio o ubicación … ADN de interés), algo asà como una dirección. El plural de locus es loci. … Un locus, en relación con la genómica, es un sitio o ubicación …
Research Funding
The Genotype-Tissue Expression (GTEx) Project will create a resource that researchers can use to study how inherited changes in genes lead to common diseases
… data release represents the largest atlas of human gene expression and catalog of trait loci to date. … in September 2010 (See: NIH launches Genotype-Tissue Expression project ), GTEx will create a resource that … Until now, no project has analyzed genetic variation and expression in as many tissues in such a large population as …
Event
On November 16-17, 2023, the National Human Genome Institute will co-sponsor a workshop, Advances in the Genetic Architecture of Complex Human Traits, to take a historically grounded and forward-looking approach towards dissecting the genetic architecture of complex traits in humans.
… – defined as the number, effect sizes, and frequency of trait-associated alleles – to differ among traits (e.g., … genetic and environmental effects influencing the same trait to be mediated by the same cellular and physiological … across levels of biological organization?  Roundtable 2 – Quantitative vs qualitative differences in the genetic …
Research Funding
The developmental Genotype-Tissue Expression initiative's goal is to catalog and analyze transcriptional profiles from a wide variety of tissues from the pediatric period, including neonates through adolescents, in a post-mortem setting.
… The human Developmental Genotype-Tissue Expression (dGTEx) project is co-funded by the National Human … as well as a tissue bank to study the regulation of gene expression in multiple relatively healthy reference neonatal, … the Non-Human Primate Developmental Genotype-Tissue Expression (NHP dGTEx) project, co-funded by NHGRI, NIMH and …
News Release
NIH will award $38.5 million over five years to the Developmental Genotype-Tissue Expression (dGTEx) project, which aims to build a widely available resource of human developmental gene expression in a multitude of tissues for use in basic and clinical research.
… The project will increase our understanding of how gene expression is regulated over time. … of high-quality tissue samples and information on gene expression — important resources that scientists needed to … to this realization, they began the Genotype-Tissue Expression (GTEx) consortium, which successfully obtained …
Educational Resources
Gene environment interaction is an influence on the expression of a trait that results from the interplay between genes and the environment.
… Gene environment interaction is an influence on the expression of a trait that results from the interplay between genes and the … and social environment. These interactions influence the expression of phenotypes. For example, most human traits and … Gene environment interaction is an influence on the expression of a trait that results from the interplay between …
Educational Resources
Epistasis is a circumstance where the expression of one gene is affected by the expression of one or more independently inherited genes.
… Epistasis is a circumstance where the expression of one gene is affected by the expression of one or more independently inherited genes. … Gene Expression, Gene Variation, DNA, Genes … Epistasis is a circumstance where the expression of one gene is modified (e.g., masked, inhibited …
Educational Resources
A phenotype is an individual's observable traits, such as height, eye color, and blood type.
… Gene, Heterozygous, Homozygous, Allele, Trait, Genotype …
Event
NHGRI, NICHD, NIMH, and ORIP program staff held a pre-application webinar with an interactive Q&A session for the Non-Human Primate Developmental Genotype-Tissue Expression (NHP dGTEx) Project.
… - Non-Human Primate Developmental Genotype-Tissue Expression (NHP dGTEx) Project (U24 Clinical Trials Not … for the Non-Human Primate Developmental Genotype-Tissue Expression Project funding opportunities and answer questions … Webinar: Non-Human Primate Developmental Genotype-Tissue Expression (NHP dGTEx) RFA-HG-21-026 …
News Release
Researchers have now identified three health conditions for which people with SCT are at increased risk.
… million people have a gene variant associated sickle cell trait (SCT) and most never have related health … Systematic review study supports that sickle cell trait increases risk for some health conditions … sickle cell trait, Vence Bonham, gene variant …