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Educational Resources
LOD stands for "logarithm of the odds." In genetics, the LOD score is a statistical estimate of whether two genes, or a gene and a disease gene, are likely to be located near each other on a chromosome.
eMERGE
Important information about RFAs, upcoming dates, frequently asked questions and helpful links.
… interactive Q&A webinar for the eMERGE Genomic Risk Assessment and Management Network funding opportunities. … What information can be used to formulate a genomic risk assessment and management plan? Each genomic risk … agreed upon by consensus of the Steering Committee. Do the polygenic risk scores (PRS) proposed for genomic risk …
News Release
eMERGE Network will support multiple clinical sites and a coordinating center with $75 million over five years.
… Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network, which establish … of disease risk in the general population. To date, polygenic risk scores , a new approach for assessing disease risk based on … the role of genomics in assessing and managing disease risk …
Educational Resources
Risk, in the context of genetics, refers to the probability that an individual will be affected by a particular genetic disorder.
… Risk … Risk, in the context of genetics, refers to the probability … Risk, as related to genetics, refers to the probability that … person’s genome and environmental exposures can influence risk. An individual’s risk may be higher because they inherit a genetic variant (or …
News
To prevent an emerging genomic technology from contributing to health disparities, a scientific team funded by the National Institutes of Health has devised new ways to improve a genetic testing method called a polygenic risk score.
… Improved genetic tests more accurately assess disease risk regardless of genetic ancestry. … new ways to improve a genetic testing method called a polygenic risk score . Since polygenic risk scores have not been … new ways to improve a genetic testing method called a polygenic risk score. …
Event
NHGRI sponsored its 12th Genomic Medicine meeting, Genomic Medicine XII: Genomics and Risk Prediction on May 6-7, 2019.
… Medicine meeting, Genomic Medicine XII: Genomics and Risk Prediction . The objectives of the meeting were: Review the state of science of polygenic risk scores and how it can be improved Examine other information … Genomic Medicine XII: Genomics and Risk Prediction …
The Genomics Landscape
In the November 2019 edition of The Genomics Landscape, NHGRI Director Eric Green highlights the International Common Disease Alliance's scientific plenary and launch meeting in September, which included an international panel on opportunities emerging outside the U.S., North America, and Europe; discussions about polygenic risk scores; and an overview about data platforms, data sharing, and ethics.
… linked to oxygen drops during sleep Schizophrenia risk gene linked to cognitive deficits in mice Scientists … publish a funding opportunity snnouncement for centers for polygenic risk score (PRS) methods and analysis for populations of … the U.S., North America, and Europe; discussions about polygenic risk scores; and an overview about data platforms, …
News Release
Researchers have now identified three health conditions for which people with SCT are at increased risk.
… conditions for which people with SCT are at increased risk. … genes with environmental exposures that may increase risk for some individuals." Hematologists and sickle cell … Researchers found a high-strength of evidence of increased risk for pulmonary embolism, proteinuria and chronic kidney …
The Genomics Landscape
In the April 2021 issue of the Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D. talks about the NIH UNITE program's goal to end structural racism in biomedical research.
… (ClinGen’s) Complex Disease Working Group and the Polygenic Score (PGS) Catalog have published a 22-item framework that identifies the minimal polygenic risk score-related information researchers should include in … to specific diseases. Studies that include polygenic risk scores are on the rise, but researchers have observed …
News Release
Genomic variants that increase risk of kidney disease are found in nearly one-third of West Africans
A study from researchers at National Institutes of Health (NIH) and their collaborators revealed a significant genetic risk factor for kidney disease in people of West African ancestry.
… and their collaborators revealed a significant genetic risk factor for kidney disease in people from Ghana and Nigeria. Their study demonstrated that having just one risk variant in a gene known as APOL1 can significantly increase the risk of developing kidney disease. APOL1 is important for the …