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News Release
NIH-led study finds genetic markers that explain up to 12% of the differences between two people’s blood pressure.
… explain up to 12% of the differences between two people’s blood pressure. … as genomic loci , that appear to influence a person’s blood pressure. Results of the study also point to several … Genetics , is one of the largest such genomic studies of blood pressure to date, including data from over 1 million …
News Release
On June 26, 2000, nearly 10 years into the 13-year project, President Bill Clinton announced an important milestone for the Human Genome Project at a major White House ceremony.
… Clinton announced an important milestone for the HGP at a White House ceremony, which included comments from U.K. Prime … of the HGP and NHGRI communities were invited to the White House to attend the ceremony. All have lifelong … Research Program, remembered standing outside of the White House's fence before the ceremony. "No one got in …
Staff
Dr. Pamela Schwartzberg is a adjunct investigator in NHGRI's Genetic Disease Research Branch.
… antigen receptors: surface immunoglobulins (Ig) on B cells, and T cell receptors (TCR) on T cells. Together with costimulatory molecules, these receptors … expanded into human immunology through the study both of cells from patients with primary immunodeficiencies and of …
News Release
TCF1 (for T cell factor-1) is essential for the creation and persistence of disease-fighting antibodies in the bloodstream.
… But its presence is necessary for the generation of white blood cells called T follicular helper (TFH) cells in response to a …
News Release
Researchers used whole genome sequence data to investigate the origin of the mutation that causes "sickling" of red blood cells.
… the origin of the mutation that causes sickling of red blood cells, which reduces their ability to carry oxygen and can … the origin of the mutation that causes "sickling" of red blood cells. ​ … the origin of the mutation that causes "sickling" of red blood cells. …
News Release
Scientists set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how the genome works.
… its make-up is different among cell types, even among cells that are similar. Investigators from two National Human … creating maps of what chromatin looks like in individual cells. They've combined several technologies, including DNA … have gained insights into how genomic information inside cells is controlled - literally turned on or off. The study …
Fact Sheet
A variety of approaches target the blood stem cells to relieve or reduce your symptoms of sickle cell disease.
… the severity of the disease. Learn more about your red blood cells to help you better understand these various approaches. … Types of treatments A variety of approaches target the blood stem cells to reduce your symptoms of sickle cell disease.  Gene … transplant , also called a stem cell transplant, your stem cells are replaced with new stem cells that have genes that …
Educational Resources
The plasma membrane, also called the cell membrane, is the membrane found in all cells that separates the interior of the cell from the outside environment.
… called the cell membrane, is the membrane found in all cells that separates the interior of the cell from the … called the cell membrane, is the membrane found in all cells that separates the interior of the cell from the outside environment. In bacterial and plant cells, a cell wall is attached to the plasma membrane on its …
Research at NHGRI
The Democratizing Education for Sickle Cell Disease Gene Therapy project developed patient-focused educational materials for the sickle cell community.
… by a change in the gene that produces hemoglobin, the red blood cells that carry oxygen throughout the body. In December … carriers for sickle cell disease have higher risks of blood clots across diverse ancestries September 12, 2024 …
Fact Sheet
Sickle cell disease resources for patients