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Staff
Dr. Peter McGuire is an investigator in NHGRI's Center for Precision Health Research.
… V., Rai, K. R., Ferrarini, M., et al. Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and … Consortium, Summar, M. Infectious precipitants of acute hyperammonemia are associated with indicators of … P.M., Moran, T.M., Lee, H.S., Bequette, B.J., Diaz, G.A. Acute metabolic decompensation due to influenza in a mouse …
News Release
NHGRI researchers have discovered a new inflammatory disorder called vacuoles, E1 enzyme, X-linked, autoinflammatory and somatic syndrome (VEXAS), which is caused by mutations in the UBA1 gene.
… and vacuoles (unusual cavity-like structures) in myeloid cells. The scientists reported their findings in the … that the mosaicism was indeed present in the patients’ myeloid cells, which are responsible for systemic … and vacuoles (unusual cavity-like structures) in the myeloid cells. Out of the combined 25 individuals, …
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… blood cancers such as myelodysplastic syndrome or leukemia. Newsletter 2 Genomic research team New additions to … This meant restricting patients to those who are having acute interventions performed such as bone marrow transplant, … with R U N X1 to increase a person’s risk of developing leukemia or make their disease more severe? Are there …
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… ministudy@nih.gov National Human Genome Research Institute Acute Infection in Mitochondrial Disease Why are we doing … Acute Infection in Mitochondrial Disease Study Flyer - …
Clinical Research
The Metabolism, Infection and Immunity (MINI) Section aims to define the relationship between infection, immunity and clinical decline in individuals with mitochondrial disease.
… Children with Mitochondrial Disease NIH Clinical Center  Acute Infection in Mitochondrial Disease  At-Home …
Genetic Disorders
Severe Combined Immunodeficiency is a severe, genetic condition of the immune system.
… to a variety of infections, including ear infections (acute otitis media), pneumonia or bronchitis, oral thrush (a … a French gene-therapy experiment had developed a type of leukemia. It was soon discovered that the mechanism used to …
Profile
After major advances in hematology, David Bodine retires with an eye towards mentorship and a garden
David Bodine, founder of the Hematopoiesis Section and chief of the Genetics and Molecular Biology Branch, advanced the fields of gene therapy and hematology in his 38 years at the NIH. Now, he plans to continue his contributions to science as an emeritus and through training the next generation of scientists.
… and ask, “Why does that one stem cell go nuts and become leukemia? Is it because of where it is, or is it because of … If you could then change the microenvironment and cure leukemia that way, it'd be a lot better than chemotherapy. …
Staff
Dr. Gordon-Lipkin is a researcher and child neurologist with expertise in neurodevelopmental disabilities in the Metabolism, Infection and Immunity (MINI) Section.
… conditions including autoimmune encephalitis, acute flaccid myelitis, and multiple sclerosis. Her current … neuroimaging, and functional profiles in children with acute flaccid myelitis at acute and convalescent stages of disease . Dev Med Child …
The Genomics Landscape
In the October 2024 issue of The Genomics Landscape, NHGRI Director Eric Green welcomes James Thomas as the new director for NIH Intramural Sequencing Center (NISC).
… has been linked to a range of diseases, including leukemia, lymphomas, and other types of cancer, but these …
News Release
The zebrafish is a powerhouse tool that helps researchers better understand the genes that are implicated in disease.
… changes that lead to certain blood cancers, such as leukemia. Although Dr. Liu acknowledged that the zebrafish is not a proven model for leukemia, its transparent embryos develop in the water away …