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News Release
Researchers build a statistical model using family health history to improve disease risk assessment
Researchers at the National Human Genome Research Institute (NHGRI) have developed a new statistical model that can predict the risk for developing diseases by combining information about family member health and lifestyle factors from family members.
… developed a new statistical model that can predict the risk for developing diseases by combining information from … to assess which conditions with a genetic component pose a risk to your health and require further testing. The … history is one of the most powerful predictors of the risk a person carries for forming type 2 diabetes,” says Dr. …
News Release
Six new grants will support researchers for new computational approaches to search millions of genomic variants for disease susceptibility.
… genomic regions containing variants that affect disease risk. Although GWAS may find hundreds of variants that appear … genes and variants actually are involved in raising the risk," said Lisa Brooks, Ph.D., program director of the NHGRI … Most variants, including many that contribute to disease risk, response to drugs, and traits such as height, are in …
Research Funding
A collaborative large-scale genome sequencing effort to identify rare risk and protective variants contributing to multiple common disease phenotypes.
… genome sequencing effort to comprehensively identify rare risk and protective variants contributing to multiple common … large-scale genome sequencing effort to identify rare risk and protective variants contributing to multiple common … Genome Sequence, Gene Variants, Genetic Risk, Common Disease, Rare Disease, Dna Sequencing, Dna …
Research at NHGRI
Families Sharing Health Assessment and Risk Evaluation (SHARE) helps you and your family learn how your family health history affects your risk for diseases.
… 2 Diabetes Heart Disease How to Use the Families SHARE Risk Algorithm … Below are links to the Families SHARE disease risk worksheets. The worksheets will help you work out family members’ risk for these diseases based on their family health history. … LM . Formative Evaluation of the Families SHARE Disease Risk Tool among Low-Income African Americans . Public Health …
News Release
NHGRI researchers have developed the Families Sharing Health Assessment and Risk Evaluation (SHARE) workbook, which helps people use their family history to assess their risk for heart disease, diabetes, breast cancer and colorectal cancer.
… have developed the Families Sharing Health Assessment and Risk Evaluation (SHARE) workbook, which helps people use their family history to assess their risk for heart disease, diabetes, breast cancer and … using the Families SHARE workbook to assess their disease risk . Credit: Harry Wedel, NHGRI. Through the Families …
Talking Glossary
A pathogenic variant is a genomic variant that may increase a person’s risk of developing a condition, disorder or disease.
… variant is a genomic variant that may increase a person’s risk of developing a condition, disorder or disease. … variant is a genomic variant that may increase a person’s risk of developing a condition, disorder or disease. In many … will develop the specific condition but increases the risk for it. Pathogenic variants can be inherited from a …
Talking Glossary
A cancer-susceptibility gene is a gene that, when changed (or mutated), gives an individual an increased risk for developing cancer
… changed (or mutated), gives an individual an increased risk for developing cancer … changed (or mutated), gives an individual an increased risk for developing cancer. Individuals who have inherited … in certain cancer-susceptibility genes have a lifetime risk of cancer that is significantly higher than the general …
News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… a key factor in understanding the elevated cancer risk associated with gene therapy. They conducted research on … a key factor in understanding the elevated cancer risk associated with gene therapy. … a key factor in understanding the elevated cancer risk associated with gene therapy. …
For Patients and Families
Genetic professionals provide information and support to individuals or families who have genetic disorders or may be at risk for inherited conditions.
… or families who have genetic disorders or may be at risk for inherited conditions. … or families who have genetic disorders or may be at risk for inherited conditions. Genetic professionals: Assess the risk of a genetic disorder by researching a family's history, …
Research Funding
The Non-Coding Variants Program explores which variants in a region associated with a disease or trait cause the higher risk for the disease or trait
… a few people. Most of these variants do not affect disease risk, response to drugs or other traits such as height. How … to find the chromosomal regions that affect the disease risk or trait. In these regions, usually many variants are … which one or few of the variants functionally affect the risk of disease or other traits. Some variants are in the …