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Research at NHGRI
NHGRI researchers develop freely available software and analysis tools to help researchers around the world analyze and explore their genomic data.
Fact Sheet
Genomic research has been central to understanding and combating the SARS-CoV-2 (COVID-19) pandemic.
… RNA to double-stranded DNA in a process called reverse transcription. The two DNA template strands are then …
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
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… ZFN must be engineered for each new target DNA sequence. Transcription activator-like effector nucleases (TALENs) In 2009, a new class of proteins called Transcription Activator-Like Effector Nucleases (TALENs) …  arrived to the genome editing scene. Similar to ZFNs, transcription activator-like effector nucleases (TALENs) are …
Research at NHGRI
The Genetic Disease Research Branch studies how genetic changes affect the structure and function of gene products leading to human disease.
… in understanding how disruptions in signaling pathways and transcription factors contribute to disease. Our …
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data​​.
Fact Sheet
Ribonucleic acid (RNA) is an essential molecule that performs many roles in the cell, from carrying the instructions to make proteins to regulating genes.
… is RNA made? RNA molecules are made by a process called transcription . In RNA, there are four different nucleotides, … nucleotide that makes up the DNA strand.  During transcription, the DNA serves as a template, and the RNA … after infecting a cell. This process is known as reverse transcription .  A type of genetic element called a …
Staff
Dr. David Bodine is the chief of and senior investigator in NHGRI's Genetics and Molecular Biology Branch.
… genome, including epigenetic marks and sites occupied by transcription factors, primarily focusing on cell lines or … state (chromatin accessibility, histone modifications, transcription factor binding, DNA methylation and 3D … stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites. Genome Res , …
Educational Resources
An intron is a portion of a gene that does not code for amino acids.
… not remain in the final mature mRNA molecule following transcription of that gene and does not code for amino acids …