Search Results
Research at NHGRI
The Genetics and Molecular Biology Branch uses genomic technologies to study the human genome and other organisms and disease mechanisms.
… investigators access to state-of-the-art bioinformatic, transgenic-animal, flow-cytometry, genomic and cytogenetic …
Jobs at NHGRI
Funded postdoctoral positions are available in the laboratory of Dr. Shawn Burgess, within NHGRI's Translational and Functional Genomics Branch.
… microscopy, flow cytometry, cytogenetics, and transgenic mouse and zebrafish cores, allowing for broad …
Jobs at NHGRI
Postdoctoral positions are available in the laboratory of Dr. Daphne W. Bell, within the Cancer Genetics and Comparative Genomics Branch of the National Human Genome Research Institute, at NIH.
… copy number analysis, flow cytometry, cytogenetics, and a transgenic mouse core, offers the trainee wide latitude in …
Jobs at NHGRI
Postdoctoral positions are available in the laboratory of Dr. Daphne W. Bell, within the Cancer Genetics and Comparative Genomics Branch of the National Human Genome Research Institute, at NIH.
… copy number analysis, flow cytometry, cytogenetics and a transgenic mouse core, offers the trainee wide latitude in …
Staff
William J. Pavan, Ph.D. is the chief of NHGRI's Genetic Disease Research Branch.
… factor SOX10 result in neural crest stem cell defects in mice that accurately model enteric nervous system … used comparative genomic sequencing analyses and zebrafish transgenic technologies to reveal cis-acting genomic elements … gene therapy can increase the lifespan of NPC1 mutant mice, and also improve neuronal and liver abnormalities. …
The Genomics Landscape
In the January 2024 issue of The Genomics Landscape, NHGRI Director Eric Green announces the appointment of Dr. Adam Phillippy as the founding director of the Center for Genomics and Data Science Research (CGDSR).
… the cellular receptor for SARS-CoV-2. In the edited mice, expression patterns of ACE2 were similar to those in …
News Release
A new study offers insights into why some people's hair goes gray in response to a serious illness or chronic stress.
… Decreasing the expression of the MITF gene in the mutant mice increased the interferon signature in melanocyte stem … of melanocytes. Overexpression of SOX10 in these mice caused hair graying. Combining the two mouse models by mating the mice produced greater amounts of gray hair. This combined …
News Release
Research points to the effects of nutrients in how DNA mutates in the mitochondria.
… life.” The researchers first searched for mutations in mice that were bred to be genetically identical. That way, … that were already present. “You could think of all the mice we studied as being large groups of identical twins,” … “The traits and characteristics we were looking at in the mice reflect a combination of genes and environment, so in …
Media Availability
Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… Hill, and his colleagues crossbred several strains of mice and examined regulatory DNA and gene activity in brain … variation and parental influence on gene activity in mice and humans, as well as the cause of complex traits and … NHGRI, NIMH, and NIGMS are parts of NIH. lllustration of mice of different colors surrounded by a DNA double helix. …
News Release
Using a recently developed DNA base-editing technique, researchers correct accelerating aging disorder.
… used a DNA-editing technique to extend the lifespan of mice with the genetic variation associated with progeria, a … this mutation might affect progeria-like symptoms in mice. "The toll of this devastating illness on affected … injection of the DNA-editing mix into nearly a dozen mice with the progeria-causing mutation soon after birth. The …