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News Release
NHGRI researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease because of evolutionary pressure to survive the bubonic plague.
… cause common periodic fever have spread in Mediterranean populations over centuries, potentially protecting people … Researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory … have been positively selected for in Mediterranean populations over centuries. The findings were published in …
Media Availability
Type 2 diabetes is a disease that affects ten percent of the world's population, but the genetics underlying the disease remain poorly understood.
… genetic changes, known as variants, are distributed among populations and how they lead to increased risk. Functional …
Research Funding
The Multi-Omics for Health and Disease Consortium aims to advance the application of multi-omic technologies to study health and disease in ancestrally diverse populations.
… to study health and disease in ancestrally diverse populations. … and standards that can be generalized across diseases and populations. It will also generate a standardized and … to study health and disease in ancestrally diverse populations. By leveraging disease contexts where multi-omic …
News Release
Researchers show critical association between diabetes and previously unlinked ZRANB3 gene.
… susceptibility to the disease in sub-Saharan African populations. The gene could also influence the development of T2D in other populations and inform further research. In a study published … have already implicated in T2D in mostly European ancestry populations. The work was funded by the National Human Genome …
Educational Resources
Ancestry-informative markers are sets of polymorphisms for a DNA sequence found in different frequencies between populations from different geographical regions.
… for a DNA sequence found in different frequencies between populations from different geographical regions. … that appear in substantially different frequencies between populations from different geographical regions of the world. … for a DNA sequence found in different frequencies between populations from different geographical regions. …
Research Funding
The IGNITE PTN supports a network of multi-site clinical groups involving diverse settings and populations to conduct two pragmatic clinical trials of genomic medicine interventions.
… Coordinating Center (CC) involving diverse settings and populations to conduct pragmatic clinical trials of genomic … through pragmatic trials in diverse and underserved populations across Indiana Todd Skaar, Ph.D., Indiana … Implementation Research in the Diverse Settings and Populations of New York City Carol Horowitz, M.D., M.P.H., …
Talking Glossary
Local ancestry refers to segments of an individual’s genome that can be traced back to ancestors from different populations living in different places and at different times.
… genome that can be traced back to ancestors from different populations living in different places and at different times. … genome that can be traced back to ancestors from different populations living in different places and at different … genome that can be traced back to ancestors from different populations living in different places and at different times. …
Educational Resources
Genetic drift is a mechanism of evolution. It refers to random fluctuations in the frequencies of alleles from generation to generation due to chance events.
… a population. Though it primarily affects small, isolated populations, the effects of genetic drift can be strong, …
Research Training
This program provides doctoral and medical graduates the opportunity to use genomic approaches to advance the growing area of health disparities research
… or behavioral research related to health disparate populations and the medically underserved, but also strives … African Americans, Hispanic Americans, American Indians/Alaska Natives, Native Hawaiians, Pacific Islanders and individuals with … Clinical Research, Behavioral Research, Health Disparate Populations, Medically Underserved Populations …
Staff
Dr. Neil Hanchard is a clinical investigator within the Center for Precision Health Research (CPHR) and head of the Childhood Complex Disease Genomics Section within the CPHR.
… diagnoses in children, and is found more often among populations of African- or Hispanic ancestries. Children with … childhood diseases in i nternationally representative populations . In addition, Dr Hanchard cared for patients … genetics of complex childhood diseases in diverse populations, internationally representative populations, …