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Research at NHGRI
Families Sharing Health Assessment and Risk Evaluation (SHARE) helps you and your family learn how your family health history affects your risk for diseases.
… 2 Diabetes Heart Disease How to Use the Families SHARE Risk Algorithm  … Below are links to the Families SHARE disease risk worksheets. The worksheets will help you work out family members’ risk for these diseases based on their family health history. … on recruiting and engaging Black men in a community-based genomic education program . BMC Public Health 25, 805 (2025). …
News Release
In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease.
… ancestral groups substantially improves identification of genomic variants associated with blood lipid levels. … ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein …
For Patients and Families
​Genetic tests may be used to identify increased risks of health problems, to choose treatments, or to assess responses to treatments.
… are the DNA instructions you inherit from your mother and your father. … individuals Identify gene changes that may increase the risk to develop a disease Identify gene changes that could be … hard to understand, however specialists like geneticists and genetic counselors can help explain what results might …
Research Funding
A collaborative large-scale genome sequencing effort to identify rare risk and protective variants contributing to multiple common disease phenotypes.
… genome sequencing effort to comprehensively identify rare risk and protective variants contributing to multiple common … for enough different examples of disease architectures and study designs to better understand the general principles of genomic architecture underlying common, complex inherited …
News Release
Researchers recommend more rigorous clinical study of dietary management practices for patients with IEMs, which may result in reformulating some medical foods.
… patients with rare inborn errors of metabolism (IEMs), and can help prevent serious and life-threatening complications. However, such special … in some patients when their use is not carefully monitored and managed, according to a research team led by scientists …
Professional Development Programs
The National Institutes of Health (NIH) seeks qualified physicians, physician assistants, nurse practitioners, pharmacists, and genetic counselors interested in acquiring credentials and experience to lead genomic medicine research and implementation programs at the NIH, major medical centers, and other organizations.
… The ACMG/NIH Genomic Program Management Fellowship has been a deeply gratifying, … to learn about grants management, collaboration and leadership. An immersive experience in various settings, … interested in acquiring credentials and experience to lead genomic medicine research and implementation programs at the …
Event
NHGRI meeting focused on research that rapidly advances best practices for the implementation of genomic sequence data into clinical care.
… Genome Research Institute (NHGRI) sponsored the meeting eMERGE & CSER: The Convergence of Genomics and Medicine at the Bethesda Hyatt in Bethesda, Maryland, on … to develop best practices for the implementation of genomic sequence data into clinical care, as well as research …
15 Ways Genomics Influences Our World
Genomics is revolutionizing health assessments before birth.
… that DNA sequencing now allows us to test for specific genomic variants in an unborn baby using a small sample of a … mother's blood? Pregnancy can be a stressful time, and for many years prenatal genetic testing has required invasive procedures with associated risk. New DNA sequencing technologies have now truly …
Genomics 101
Find out how the rapidly emerging field of genomics is transforming our understanding of human health and enabling advances that benefit all of humankind.
… to the way your body responds to diseases, medications, and aging. Find out how the rapidly emerging field of … genomics is transforming our understanding of human health and enabling advances that benefit all of humankind. … and partnerships help spark scientific curiosity, improve genomic literacy, and foster engagement among learners in …
News Release
Six new grants will support researchers for new computational approaches to search millions of genomic variants for disease susceptibility.
… computational approaches for searching among millions of genomic variants to find those that make a difference in … or in other traits. The awards are for three years each and total approximately $13 million, pending the availability … by the National Human Genome Research Institute (NHGRI) and the National Cancer Institute, both parts of NIH. …