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Fact Sheets
DNA sequencing determines the order of the four chemical building blocks - called "bases" - that make up the DNA molecule.
… DNA sequencing determines the order of the four chemical building … Sequencing DNA means determining the order of the four … genes on or off. In addition, and importantly, sequence data can highlight changes in a gene that may cause disease. … the pairing also underlies the methods by which most DNA sequencing experiments are done. The human genome contains …
Events
Data sharing has been a central tenet of the field of genomics since the Human Genome Project.
… Data sharing has been a central tenet of the field of … Genome Project. While many recognize that sharing genomic data is critical to scientific progress, considerable privacy … and other concerns have been raised over sharing genomic data too broadly and openly. It is immensely challenging for …
Research at NHGRI
NHGRI center focused on computationally intensive approaches to analyze large-scale genomic data and identifying genetic contributions to human disease.
… The Center for Genomics and Data Science Research focuses on the development and … approaches to analyze large-scale genetic and genomic data, with a particular focus on identifying genetic … center has dramatically improved the performance of genome sequencing methods, uncovering the genomes of thousands of …
Funding Opportunities
Funding Opportunities for Investigator-Initiated Research in Computational Genomics and Data Science
The Computational Genomics and Data Science Program Announcements (PARs) invite applications for investigator-initiated research efforts fostering innovation in computational genomics, data science, statistics, bioinformatics, and data visualization and exploration.
… Infrastructure for Multiple Sample Single Cell Genomic Data HG013409 WANG, SHENG UNIVERSITY OF WASHINGTON Deep … Application of Computational Methods for Single Cell DNA Sequencing Data HG012573 RAY, DEBASHREE JOHNS HOPKINS … and software implementation for analysis of nascent RNA sequencing data HG012944 GREENLEAF, WILLIAM JAMES STANFORD …
Event
On November 30th, 2020, NHGRI convened a virtual meeting for journal editors and NHGRI/NIH staff to discuss genomic data sharing.
… for journal editors and NHGRI/NIH staff to discuss genomic data sharing. The goal of this meeting was to learn more … papers (“Journals”); and, to develop ideas to improve data sharing policy, its implementation, and the practice of leveraging data standards to optimize the utility of genomic data shared …
Event
On May 19-20, 2016, the National Human Genome Research Institute (NHGRI) hosted a two-day workshop where participants were asked to weigh the benefits and risks of sharing aggregate genomic data with secondary users.
… Update Workshop on Establishing a Central Resource of Data from Genome Sequencing Projects Report Resolving Individuals Contributing … weigh the benefits and risks of sharing aggregate genomic data with secondary users. … Workshop on Sharing Aggregate Data … weigh the benefits and risks of sharing aggregate genomic data with secondary users. …
News Release
Researchers, clinicians, and computational biologists meet to consider future opportunities for NHGRI's Genome Sequencing Program.
… Human Genome Research Institute's (NHGRI) flagship Genome Sequencing Program (GSP) at a July 28 - 29 meeting in … The workshop, "Future Opportunities for Genome Sequencing and Beyond: A Planning Workshop for the National … sequencing technology applications and develop important data resources for the biomedical research community. …
News Release
NHGRI-funded CSER investigators and colleagues point to need for greater evidence that DNA sequencing helps patients.
… In the nearly four years since its launch, the Clinical Sequencing Exploratory Research (CSER) program has made … disease; improved the analysis and interpretation of DNA sequencing results; and provided new insights into the … Maryland, for a one-day conference, Integrating Genomic Sequencing into Clinical Care: CSER and Beyond . The meeting …
Media Availability
Researchers have created a promising new method to accurately and more comprehensively analyze and interpret DNA sequence information from cancer patients.
… Nature Medicine . Their work is supported by the Clinical Sequencing Exploratory Research program at the National Human … of how the clinician might best use the large amounts of data in a cancer patient's protein-coding exome, the portion of the genome where many key …
Research Funding
The Genome Sequencing Program uses genome sequencing to identify genes and genomic variants underlying human inherited disease.
… The Genome Sequencing Program is consists of the following centers … The NHGRI Genome Sequencing Program (GSP) has evolved from NIH's participation … developing general paradigms and approaches, and creating data resources and tools. The specific activities of the …