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News Release
The U.S. National Institutes of Health (NIH) has long invested in basic genetics and genomics research, clinical trials, as well as translational medicine and social science studies, to advance our understanding of this widespread illness to help develop effective therapies.
… the U.S. Food and Drug Administration (FDA) approved two gene therapies for the treatment of sickle cell disease in … One of the new sickle cell treatments uses the CRISPR gene-editing system, a first for humans in the U.S.  NIH funds … For more information, visit: Sickle cell disease gene therapy education project Talking Glossary of Genomic …
News Release
NHGRI researchers asked patients, parents and physicians in the sickle cell disease community (SCD) what they wanted and needed to know about genome editing to make informed decisions about participating in genome-editing clinical trials.
… As public interest and expanded research in human genome editing grows, many questions remain about ethical, legal and … community what they wanted and needed to know about genome editing to make informed decisions about participating in genome-editing clinical trials. Gene-editing treatments, which appear to provide a potential …
Media Advisory
NHGRI hosts a Reddit AMA with Jennifer Doudna, Ph.D., and her research group.
… her research, her new, NHGRI-funded Center for Genome Editing and Recording, and the CEGS program. The CEGS program … focus on refining technologies, such as the CRISPR-Cas9 gene-editing system, that alter, detect, and record the sequence …
The Genomics Landscape
In the December 2018 edition of The Genomics Landscape, NHGRI Director Eric Green recaps progress from NHGRI strategic planning process events in 2018.
… Research NIH Researcher Presents Encouraging Results for Gene Therapy for Severe Sickle Cell Disease Blast Off! … Genomes for Precision Medicine Statement on Claim of First Gene-Edited Babies by Chinese Researcher NHGRI's Dr. Andy …
The Genomics Landscape
In the October 2018 edition of The Genomics Landscape, NHGRI Director Dr. Eric Green highlights Dr. Dan Kastner as the Federal Employee of the Year.
… that used positional cloning to identify MEFV, the gene mutated in familial Mediterranean fever (FMF). MEFV … Project Releases First 15 High-Quality Reference Genomes Gene Editing in Dogs Boosts Hope for Kids with Muscular Dystrophy …
News Release
NIH researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be enhanced.
… France, removed these extra 45 genes using CRISPR gene-editing technology. Dr. Bianchi’s group then compared the two …
The Genomics Landscape
In the October 2019 edition of The Genomics Landscape, NHGRI Director Eric Green focuses on recent efforts to make the human genome reference sequence useful to basic and clinical researchers and how increasing the representation of human genomic variation will remain key components of NHGRI’s Human Genome Reference Program.
… Nano-sized solution for efficient and versatile CRISPR gene editing ALS gene may be a hitchhiker’s guide to the neuron Gene …
The Genomics Landscape
In the March 2019 edition of The Genomics Landscape, NHGRI Director Eric Green details ClinGen, the first FDA-recognized Public Human Genetic Variant Database.
… challenge has been establishing which genes and gene variants are relevant in disease. ClinGen was launched … As of February 1, 2019, ClinGen has classified 670 gene-disease pairs. ClinGen is primarily funded by the NHGRI, … The Gene Ontology (GO) Resource, one of the founding members of …
News Release
The NHGRI Short Course in Genomics brings the latest genomics science to the classroom.
… topics, including genome sequencing, CRISPR and other gene-editing methods, the human microbiome, and ethical and …
News Release
Using a recently developed DNA base-editing technique, researchers correct accelerating aging disorder.
… Using a recently developed DNA base-editing technique, researchers correct accelerating aging … Researchers have successfully used a DNA-editing technique to extend the lifespan of mice with the … Progeria is caused by a mutation in the nuclear lamin A gene in which one DNA base C is changed to a T. Researchers …