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Educational Resources
Sickle cell disease is a hereditary disease seen most often among people of African ancestry.
… recessive trait. The mutation causes the red blood cells to take on an unusual sickle shape. Individuals …
Staff
Dr. Colin Fletcher is the program director in the Knockout Mouse Project (KOMP) in NHGRI's Extramural Research Program.
… 8,500 knockouts of mouse genes, in the form of embryonic stem (ES) cells. He is now working to implement The Knockout Mouse … by multiple Institutes. Prior to joining the National Human Genome Research Institute (NHGRI), Dr. Fletcher was a … Mouse Phenotyping Project (KOMP2), mouse genes, embryonic stem cells …
News Release
NHGRI researchers have released new educational materials to help the sickle cell disease community learn about gene therapies for the disease.
… disease are now available from researchers at the National Human Genome Research Institute (NHGRI), part of the National … the disease comes from the “sickle” shape of the red blood cells that form in patients with the disorder. Red blood cells contain the protein hemoglobin, which carries oxygen in …
Policy Issues
Federally-funded research with human participants must comply with regulations that protect the rights and welfare of the participants.
… The use of human participants in biomedical, clinical and … or other methods. All federally-funded research with human participants such as that supported by NIH must comply … All research with human participants supported by the United States government, … is subject to the Federal Policy for the Protection of Human Research Subjects, or 'Common Rule' ( Code of Federal …
News Release
Three research teams funded by NIH gather data at the most basic molecular levels about the biological processes that make up the human microbiome.
… tens of thousands of microbial species that live in or on human beings - the human microbiome - they would find therapies for a host of … Now, in the second phase of the Human Microbiome Project, three research teams funded by the … have changed, too. For years the number of microbial cells on or in each human was thought to outnumber human …
Research Funding
MorPhiC aims to develop a consistent catalog of molecular and cellular phenotypes for null alleles for every human gene by using in-vitro multicellular systems.
… knockout and multimodal phenotyping in genetically diverse human genomes UM1 HG012654 Mazhar Adli Northwestern … Molecular and cellular characterization of essential human genes UM1 HG012649 Luke Gilbert University of … a Catalog of Cellular Programs to Identify and Annotate Human Disease Genes U01 HG013176 Sheng Li Jackson Laboratory …
News Release
NHGRI researchers have produced the first end-to-end DNA sequence of a human chromosome. The results show that generating a precise, base-by-base sequence of a human chromosome is now possible, and will enable researchers to produce a complete sequence of the human genome.
… Researchers at the National Human Genome Research Institute (NHGRI), part of the National … have produced the first end-to-end DNA sequence of a human chromosome. The results, published today in the journal … show that generating a precise, base-by-base sequence of a human chromosome is now possible, and will enable researchers …
News Release
NHGRI published its “Strategic vision for improving human health at The Forefront of Genomics” in the journal Nature. This vision describes the most compelling research priorities and opportunities in human genomics for the coming decade, signaling a new era in genomics for the Institute and the field.
… NHGRI's 2020 Strategic Vision describes opportunities in human genomics for improving human health. … The National Human Genome Research Institute (NHGRI), part of the National … this week published its “ Strategic vision for improving human health at The Forefront of Genomics ” in the journal …
Media Advisory
The NIH-funded Integrative Human Microbiome Project presented at the International Human Microbiome Congress.
… the National Institutes of Health (NIH)-funded Integrative Human Microbiome Project (iHMP), which is coordinated by the National Human Genome Research Institute (NHGRI), will present findings at the 5th International Human Microbiome Congress. … the National Institutes of Health (NIH)-funded Integrative Human Microbiome Project (iHMP), which is coordinated by the …
News Release
NIH investigators have discovered that genomic switches of a blood cell are key to regulating the human immune system.
… genomic switches of a blood cell are key to regulating the human immune system. The findings, published in Nature today, … Genomics and Metabolic Genetics Branch at the National Human Genome Research Institute (NHGRI). Autoimmune diseases … occur when the immune system mistakenly attacks its own cells, causing inflammation. Different tissues are affected …