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News Release
A new study offers insights into why some people's hair goes gray in response to a serious illness or chronic stress.
… Decreasing the expression of the MITF gene in the mutant mice increased the interferon signature in melanocyte stem … of melanocytes. Overexpression of SOX10 in these mice caused hair graying. Combining the two mouse models by mating the mice produced greater amounts of gray hair. This combined …
News Release
Research points to the effects of nutrients in how DNA mutates in the mitochondria.
… life.” The researchers first searched for mutations in mice that were bred to be genetically identical. That way, … that were already present. “You could think of all the mice we studied as being large groups of identical twins,” … “The traits and characteristics we were looking at in the mice reflect a combination of genes and environment, so in …
Research Funding
NHGRI's programs and projects support research in one of six domains to advance the field of genomics and improve human health.
… Project Implementing Genomics into Practice (IGNITE) Knockout Mouse Program (KOMP) Large-Scale Genome Sequencing …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in September 2023.
… to Promote Diversity in Health-Related Research 33 Knockout Mouse Phenotyping Project (KOMP2) KOMP2 Website IMPC … of Leukemia Progression in the Cbfb-MYH11 Knockin Mice by Single Cell RNA Sequencing" Turriff et al. – …
Staff
Dr. Shawn Burgess is the co-deputy director of NHGRI's Intramural Research Program.
… last decade has been focused on developing efficient gene knockout technologies in zebrafish, coupled with efficient … M, Burgess SM, Lin S. A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. …
Media Availability
Researchers find that more than 80 percent of mouse genes had variations in the nearby regulatory DNA that affects gene activity.
… Hill, and his colleagues crossbred several strains of mice and examined regulatory DNA and gene activity in brain … variation and parental influence on gene activity in mice and humans, as well as the cause of complex traits and … NHGRI, NIMH, and NIGMS are parts of NIH. lllustration of mice of different colors surrounded by a DNA double helix. …
News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… of times more quickly than mammalian models such as mice (although not nearly so fast as flies). It can be made … implanted aggressively metastasizing human cancer cells in mice, and then treated the mice with an inhibitor that had seemed most effective in …
News Release
Using a recently developed DNA base-editing technique, researchers correct accelerating aging disorder.
… used a DNA-editing technique to extend the lifespan of mice with the genetic variation associated with progeria, a … this mutation might affect progeria-like symptoms in mice. "The toll of this devastating illness on affected … injection of the DNA-editing mix into nearly a dozen mice with the progeria-causing mutation soon after birth. The …
Staff
Dr. Randy Chandler is an associate investigator in the Organic Acid Research Section of the Metabolic Medicine Branch in NHGRI.
… that AAV vectors can cause insertional mutagenesis in mice treated as neonates and that this toxicity is … cause of upregulation of oncogenes and tumorigenesis in mice treated with AAV. Importantly, his AAV integration … pathophysiology. He was the first to demonstrate that mice and patients with MMA both have a tissue-specific …
News Release
NIH researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be enhanced.
… mouse model. Scientists often use different strains of mice as animal models to study human diseases because most genes in humans have similar counterparts in mice. “A mouse model that more precisely captures the … a byproduct of how the model was developed. Humans and mice have very similar genomes, but the chromosomes that make …