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Educational Resources
Translation is the process of translating the sequence of a messenger RNA (mRNA) molecule to a sequence of amino acids during protein synthesis.
… where mRNA is read and translated into the string of amino acid chains that make up the synthesized protein. …
News Release
The Clinical Sequencing Exploratory Research Consortium has offered an ethical framework to guide pediatricians in pursuing clinical sequencing studies.
… More than many other diagnostic technologies, genome sequencing carries the possibility of incidental or … information they should disclose, and to whom, when genome sequencing uncovers signs of possible genetic risk for disease in patients who are too young to give informed …
Fact Sheets
DNA sequencing determines the order of the four chemical building blocks - called "bases" - that make up the DNA molecule.
… DNA sequencing determines the order of the four chemical building … Sequencing DNA means determining the order of the four … information that is carried in a particular DNA segment. For example, scientists can use sequence information to … always pairs with guanine (G). This pairing is the basis for the mechanism by which DNA molecules are copied when …
News Release
Artificial intelligence tools help scientists decode genomic disorders and communicate genomic risks
NHGRI researchers are increasingly using artificial intelligence tools to answer compelling questions in genomics, such as predicting rare genetic disorders and their severity, and to understand how genomic information influences decision-making.
… researchers explain how they use artificial intelligence for their genomic studies. … and treat genetic conditions. Artificial intelligence tools , which mimic human intelligence to solve problems, are … (NHGRI) are increasingly using artificial intelligence tools to answer compelling questions in genomics, such as …
News Release
NHGRI awards $6.7 million in new research grants to develop DNA sequencing technologies that are more sensitive, faster, cheaper and more accurate.
… new awards," said Michael Smith, Ph.D., program director for NHGRI's Genome Technology Program. "The awards enable novel research in RNA function across a broad swath of … awards have been made through a program called the Novel Nucleic Acid Sequencing Technology Development program …
Research Funding
The Genome Sequencing Program uses genome sequencing to identify genes and genomic variants underlying human inherited disease.
… The Genome Sequencing Program is consists of the following centers … (HGP). In addition to creating an essential resource for biomedical research, the HGP helped define NHGRI's niche: … paradigms and approaches, and creating data resources and tools. The specific activities of the Genome Sequencing …
The Genomics Landscape
In the May 2020 edition of The Genomics Landscape, NHGRI Director Eric Green details how NIH is ramping up research on COVID-19; NHGRI's expansion of its Genome Technology Program; and the the DiY Genome: Unlocking Life's Code exhibition toolkit.
… is being held remotely. Ironically, the other instance was for my very first NACHGR meeting! There I was in my rookie … COVID-19 and, despite the nice spring weather, the need for a remote NACHGR meeting. With that historic preamble in … that the 89th meeting of the National Advisory Council for Human Genome Research will take place on May 18-19. As …
News Release
NHGRI convened geneticists, biologists, clinicians, bioinformatics specialists and more to provide expert advice on the future of its Genome Sequencing Program.
… provide expert advice on the future of its flagship Genome Sequencing Program (GSP). … (CSER) program and the Genome Sequencing Informatics Tools (GS-IT) program. NHGRI should continue its role as a … Centers for Mendelian Genomics have made discoveries of novel genetic bases or novel clinical features of more than …
News Release
NHGRI-funded CSER investigators and colleagues point to need for greater evidence that DNA sequencing helps patients.
… In the nearly four years since its launch, the Clinical Sequencing Exploratory Research (CSER) program has made … disease; improved the analysis and interpretation of DNA sequencing results; and provided new insights into the … variants found in DNA sequencing. "We need to develop new tools and standards for genomic testing. Labs should work …