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News Release
NIH researchers and collaborators have found that that sickle cell trait is prevalent among diverse human populations.
… Study finds that sickle cell trait is prevalent among diverse human populations. … collaborators have found that being a carrier for sickle cell disease, known as having sickle cell trait , increases … also known as venous thromboembolism. Through statistical analyses, participants were grouped based on their genetic …
Educational Resources
Ribonucleic acid (RNA) is a molecule similar to DNA. Unlike DNA, RNA is single-stranded.
… (RNA) is a molecule similar to DNA. Unlike DNA, RNA is single-stranded. … Cell, Genetic Code, Deoxyribonucleic Acid (DNA), Protein, … to DNA. Unlike DNA, however, RNA is most often single-stranded. An RNA molecule has a backbone made of … (RNA) is a molecule similar to DNA. Unlike DNA, RNA is single-stranded. …
Fact Sheet
Learn about the different types of hemoglobin.
… To understand sickle cell disease and gene therapy , you should first know about … Hemoglobin types and sickle cell disease  Your red blood cells contain hemoglobin , a … oxygen to your body’s organs and tissues. Every red blood cell contains thousands of hemoglobin molecules.   The …
Educational Resources
Apoptosis is the process of programmed cell death.
… Apoptosis is the process of programmed cell death. … Programmed Cell Death, Development, DNA Repair, Cancer, Tumor, Cell Division … Apoptosis is the process of programmed cell death. It is used during early development to eliminate … is for some reason prevented, it can lead to uncontrolled cell division and the subsequent development of a tumor. …
Research Funding
Funded in 2016 to harmonize, access, and analyze the data produced by the sequencing centers.
… undertake novel, investigator-initiated computational analyses on GSP data and develop methods to discover variants … Medicine Program  to harmonize joint variant calls and analyses, functional annotations, and phenotypic information. …
Clinical Research
The INSIGHTS study is exploring sickle cell disease in adults.
… into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers Study (INSIGHTS) study is exploring sickle cell disease in adults by looking at many factors, including … factors influence the onset and development of sickle cell leg ulcers. While leg ulcers are a primary focus of this …
News Release
Genomic analyses turned up genes that belong to inflammatory pathways.
… translated). In this case, the effect leads to a form of cell death that causes inflammation. Dr. Kastner had a hunch … Center staff. "The genes that turned up in the genomic analyses of the disease we focus on belong to inflammatory … Genomic analyses turned up genes that belong to inflammatory pathways. …
Fact Sheets
A transcriptome is a collection of all the gene readouts present in a cell.
… is a collection of all the gene readouts present in a cell. … is a collection of all the gene readouts present in a cell. There are various kinds of RNA. The major type, called … to ribosomes , the molecular machines located in the cell's cytoplasm; then the ribosomes read, or "translate," …
Educational Resources
A point mutation is when a single base pair is altered.
… A point mutation is when a single base pair is altered. … A point mutation occurs in a genome when a single base pair is added, deleted or changed. While most … A point mutation is when a single base pair is altered. …
Educational Resources
The nucleolus is a region found within the cell nucleus that is concerned with producing and assembling the cell's ribosomes.
… The nucleolus is a region found within the cell nucleus that is concerned with producing and assembling the cell's ribosomes. … Messenger RNA (mRNA), Ribonucleic Acid (RNA), Translation, Cell, Cytoplasm, Protein, Nucleus, Ribosome … The nucleolus is a spherical structure found in the cell’s nucleus whose primary function is to produce and …