Search Results
Facet (Page)
Refine Your Search
Audiences
Content Formats
Sections
News Release
Investigators with The Cancer Genome Atlas have discovered genomic differences in head and neck cancers caused by infection with the human papillomavirus.
… head and neck cancers, noticeably in oropharyngeal tumors, has created an even greater sense of urgency in the … behind the mouth. "We're uncovering differences between tumors with and without HPV infection, and these new data are … the study, researchers performed genomic analyses on 279 tumors - head and neck squamous cell carcinomas (HNSCC) - …
Research Funding
Effort to accelerate understanding of the molecular basis of cancer using genome analysis technologies, including large-scale genome sequencing.
… Reports First Results of Comprehensive Study of Brain Tumors  (2008)  The Cancer Genome Atlas Awards Funds for …
News Release
Investigators with The Cancer Genome Atlas Research Network have identified new potential therapeutic targets for a major form of bladder cancer.
… (which is commonly affected in cancers) in 44 percent of tumors. TP53 makes the p53 tumor suppressor protein, which … identified potential drug targets in 69 percent of the tumors evaluated. They found frequent mutations in the ERBB2 … responsible for cervical cancer - was found in bladder tumors. This suggests that viral infection can contribute to …
Staff
Dr. Bell is a senior investigator at the National Human Genome Research Institute's Cancer Genetics and Comparative Genomics Branch.
… somatic mutations in PI3-kinase in endometrial tumors, thus uncovering previously unrecognized cohorts of … alterations that drive clinically aggressive endometrial tumors, and to understand their functional consequences. Dr. … the genetic and genomic alterations that drive solid tumors. In her previous position at Massachusetts General …
News Release
The TCGA network describes uterine and bile duct cancer.
… uncontrolled cell growth that is the hallmark of malignant tumors. Last month, two publications from the TCGA network …
News Release
Researchers from The Cancer Genome Atlas Research Network identify novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma.
… identified, clinicians may be able to treat patients whose tumors have specific gene changes with drugs currently …
For Patients and Families
​Pharmacogenomics combines the science of how drugs work, called pharmacology, with the science of the human genome, called genomics.​
… (Herceptin). This therapy works only for women whose tumors have a particular genetic profile that leads to … (Tarceva), work much better in lung cancer patients whose tumors have a certain genetic change. On the other hand, … very well in the 40 percent of colon cancer patients whose tumors have a particular genetic change. Pharmacogenomics may …
Fact Sheets
Epigenomics is a field in which researchers chart the locations and understand the functions of all the chemical tags that mark the genome.
… of cancer, or to a failure of the immune system to destroy tumors. In a type of brain tumor called glioblastoma, doctors … that counteracts temozolomide. Glioblastoma patients whose tumors have such methylated genes are far more likely to …
News Release
NHGRI researchers have identified new genes associated with the Erdheim-Chester disease (ECD) and some possible new therapies.
… seen in colon cancer, lung cancer, thyroid cancer, brain tumors and some blood cancers. Other patients had mutations …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… codes for a protein that normally suppresses the growth of tumors by arresting cell division. Humans born with mutations … with more than half of human cancers and often lead to tumors in a particular set of tissues. However, when the p53 gene is knocked out in mice, the animals develop tumors in a different array of tissues.Despite these …