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Staff
Dr. David Bodine is the chief of and senior investigator in NHGRI's Genetics and Molecular Biology Branch.
… After postdoctoral work at NIH's National Heart, Lung and Blood Institute, Dr. Bodine founded the Hematopoiesis Section … College in 2013 for his contributions to the genetics of blood disorders. As a graduate student, he was the recipient … National Disease Research Interchange and the Wisconsin Blood Center. Dr. Bodine is an active member of the American …
News Release
Researchers explored patients', parents' and physicians' perspectives on the use of CRISPR-Cas9 gene-editing to reverse sickle cell disease.
… community." In September, NIH's National Heart, Lung, and Blood Institute launched the Cure Sickle Cell Initiative to … Sickle cell disease is the most common inherited blood disorder in the United States, affecting approximately … is caused by a single gene mutation that causes red blood cells to take on an unusual sickle shape. People affected by …
Educational Resources
Sickle cell disease is a hereditary disease seen most often among people of African ancestry.
… an autosomal recessive trait. The mutation causes the red blood cells to take on an unusual sickle shape. Individuals …
News Release
NHGRI researchers have released new educational materials to help the sickle cell disease community learn about gene therapies for the disease.
… of Health, particularly the National Heart, Lung, and Blood Institute.” “Most importantly, the project included … of the disease comes from the “sickle” shape of the red blood cells that form in patients with the disorder. Red blood …
Educational Resources
Apoptosis is the process of programmed cell death.
… It is used during early development to eliminate unwanted cells; for example, those between the fingers of a developing … hand. In adults, apoptosis is used to rid the body of cells that have been damaged beyond repair. Apoptosis also …
Educational Resources
The nucleolus is a region found within the cell nucleus that is concerned with producing and assembling the cell's ribosomes.
News Release
In a study published in the journal Science, collaborators at NHGRI, the National University of Ireland, Galway, and the Whitney Laboratory for Marine Bioscience at the University of Florida, Augustine, reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ cells in a cycle that can repeat endlessly.
… called Hydractinia, does so because it produces germ cells, which are precursors to eggs and sperm, nonstop … reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ cells in a cycle that can repeat endlessly. …
Fact Sheets
A transcriptome is a collection of all the gene readouts present in a cell.
… contains the instructions needed to build and maintain cells. These instructions are spelled out in the form of … when and where each gene is turned on or off in the cells and tissues of an organism. Depending on the technique … nearly every cell contains the same genes, but different cells show different patterns of gene expression. These …
The Genomics Landscape
In the July 2020 edition of The Genomics Landscape, NHGRI Director Eric Green recalls the White House event announcing the draft human genome sequence.
… on June 26, 2000 – President Bill Clinton held a White House event to announce the completion of a draft … genome. The ceremony took place in the East Room of the White House, where politicians, ambassadors, scientists, … draft sequence of the human genome. In attendance at the White House event were several members of the NHGRI and HGP …
Educational Resources
A centrosome is a cellular structure involved in the process of cell division.
… help separate the replicated chromosomes into the daughter cells. …