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The Genomics Landscape
In the October 6, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., celebrates the 25th anniversary of the NIH Intramural Sequencing Center (NISC). a well-respected and highly used large-scale DNA sequencing center that exemplifies the evolution of the field of genomics and the ever-increasing abilities to produce prodigious amounts of genomic data.
…  As the sun came up on 1997, the Human Genome Project (then in its seventh of 13 years) was adding megabases of genome sequence to public databases weekly, as large-scale DNA sequencing had advanced substantially. At that time, it … 6,000 out of the 19,000 protein-coding genes in the human genome have not been well-studied. The MorPhiC program seeks …
Research at NHGRI
The NIH Intramural Sequencing Center is a multi-disciplinary genomics facility that emphasizes the generation and analysis of DNA sequence.
… The NIH Intramural Sequencing Center (NISC) , established in 1997, is a … procedures. NISC's role within the National Human Genome Research Institute (NHGRI), and more broadly across NIH, aims to advance genome sequencing and its many applications, with a goal not …
Profile
Jim Mullikin pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics.
… Mullikin pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics. … are you most proud of? Jim Mullikin: Of course, the Human Genome Project is one of the top ones. I started working on … the whole progress, from the very early days of Sanger sequencing all the way to a complete telomere-to-telomere …
News Release
NIH is awarding $18.9 million towards research that aims to accelerate the use of genome sequencing in clinical care for all individuals.
… towards research that aims to accelerate the use of genome sequencing in clinical care. The new awards will generate … The research is being funded as part of the Clinical Sequencing Evidence-Generating Research (CSER2) Consortium. … , initiated in 2010 and funded by the National Human Genome Research Institute (NHGRI) and the National Cancer …
News Release
Jeffery Schloss, Ph.D., founding director of the Division of Genome Sciences, is embarking on a new journey: retirement.
… After an extraordinary career at the National Human Genome Research Institute (NHGRI), Jeffery Schloss, Ph.D., founding director of the Division of Genome Sciences, is embarking on a new journey: retirement. … for a program director at the National Center for Human Genome Research (NCHGR), what is now known as NHGRI. He …
Talking Glossary
Next-generation DNA sequencing (abbreviated NGS) refers to the use of technologies for sequencing DNA that became available shortly after the completion of the Human Genome Project (which relied on the first-generation method of Sanger sequencing).
… Next-Generation DNA Sequencing … Next-generation DNA sequencing (abbreviated NGS) refers to the use of technologies for sequencing DNA that became available shortly after the completion of the Human Genome Project (which relied on the first-generation method … became available shortly after the completion of the Human Genome Project (which relied on the first-generation method …
News Release
NHGRI researchers have produced the first end-to-end DNA sequence of a human chromosome. The results show that generating a precise, base-by-base sequence of a human chromosome is now possible, and will enable researchers to produce a complete sequence of the human genome.
… Researchers at the National Human Genome Research Institute (NHGRI), part of the National … researchers to produce a complete sequence of the human genome.   “This accomplishment begins a new era in genomics … incredibly long, consisting of about 6 billion bases, DNA sequencing machines cannot read all the bases at once. …
News Release
NIH lost a key member of its broader genomics team when Robert Blakesley, Ph.D., director of the NISC sequencing group at NIH, retired on Dec. 31, 2015.
… 31 retirement of Robert Blakesley, Ph.D., director of the sequencing group at the NIH Intramural Sequencing Center (NISC) in Rockville, Maryland. … Eric Green, M.D., Ph.D., director of the National Human Genome Research Institute (NHGRI), part of NIH. "When I …
Talking Glossary
Nanopore DNA sequencing is a laboratory technique for determining the exact sequence of nucleotides, or bases, in a DNA molecule.
… Nanopore DNA Sequencing … Nanopore DNA sequencing is a laboratory technique for determining the … Nanopore DNA sequencing is a laboratory technique for determining the … that cells use to develop and operate. Nanopore DNA sequencing involves reading the code of single DNA strands as …
The Genomics Landscape
In the October 2024 issue of The Genomics Landscape, NHGRI Director Eric Green welcomes James Thomas as the new director for NIH Intramural Sequencing Center (NISC).
… Genome-wide detection of somatic mosaicism at short tandem … While the cells in our bodies largely share the same genome, some cells can have genomic differences. This … The researchers applied the tool to study 460 whole-genome sequences, revealing hundreds of mosaic short tandem …