Search Results
News Release
NHGRI researchers investigated the Behcet's disease using Illumina's Immunochip.
… Behçet's disease is a disease that destroys blood vessels through systemic … destroying inflammation of the eyes. Research suggests the disease develops due to pathogen exposure, along with a mix of genetic and … many of which are involved in immune response to invading pathogens. The study - Dense genotyping of …
Educational Resources
Huntington's disease is an inherited disease characterized by the progressive loss of brain and muscle function.
… Huntington's Disease … Huntington's disease is an inherited disease characterized by the progressive loss of brain and … Huntington's Disease, Genetic Disease, Genes, Autosomal Dominant … copy of the responsible gene (called HTT) is sufficient to cause the disease. …
Research at NHGRI
The NHGRI Cancer Genetics and Comparative Genomics Branch identifies and study genes that contribute to cancer susceptibility and progression.
… The Cancer Genetics and Comparative Genomics Branch seeks to identify and study genes that contribute to cancer susceptibility and progression. … and somatic (body cell) mutations that contribute to cancer susceptibility syndromes and to the development of … or production of tumors-tumorigenesis-can result from genomic alterations that are inherited or alterations that …
News Release
More research must be done to understand the interactions of ancient genes with modern environments.
… mutations that have evolved over thousands of years to protect Africans from disease-causing pathogens. … in the colonies, resulting in a wide range of genetic contributions to different groups of people. The average … Project, the first comprehensive characterization of genomic diversity across sub-Saharan Africa. The study, which …
Clinical Research
The goal of this study is to learn more about the genetic contributions to the severity of disease of COVID-19.
… a (240) 274-6777 o covidcode@nih.gov . This study aims to learn more about the genetic contributions to the severity of COVID-19. We hope to use this information … tested positive for SARS-CoV-2 infection may be eligible to join. We will use the clinical information and samples of …
The Genomics Landscape
In the July 2020 edition of The Genomics Landscape, NHGRI Director Eric Green recalls the White House event announcing the draft human genome sequence.
… for many of your organizations, NHGRI and NIH are starting to bring some of our staff back to the physical workplace. This will obviously be a complex … remotely from home or at our physical workspaces at NIH. To foster a safe and fair research and training environment, …
Policy Issues
Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.
… Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas. … research exploring human and nonhuman genomes is critical to help scientists understand the basic biology underlying disease, as well as to discover new possible therapeutic …
News Release
Researchers explored patients', parents' and physicians' perspectives on the use of CRISPR-Cas9 gene-editing to reverse sickle cell disease.
… perspectives on the use of CRISPR-Cas9 gene-editing to reverse sickle cell disease (SCD). … a gene editing technology that researchers have harnessed to explore two approaches for reducing the burden of the … generation of therapies. Sickle cell disease is the most common inherited blood disorder in the United States, …
Research Funding
​The Undiagnosed Diseases Network accelerates discovery and innovation in how we diagnose and treat patients with previously undiagnosed diseases.
… Applications UDN does not accept all applicants due to the complex nature of the body and the diseases being … list of UDN Coordinating Center publications dating back to 2015. … clinical sites. The DMCC will also support Research Cores (genomic sequencing, model organisms screening center, …
News Release
Researchers from The Cancer Genome Atlas Research Network identify novel mutations in a well-known cancer-causing pathway in lung adenocarcinoma.
… cancer-causing pathway in lung adenocarcinoma, the most common subtype of lung cancer. Knowledge of these genomic changes may expand the number of possible therapeutic targets for this disease and potentially identify a greater number of patients … Green, M.D., Ph.D. "These results give us important new genomic insights into the development and behavior of an …