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The Genomics Landscape
In the October 1, 2020 edition of The Genomics Landscape, Dr. Eric Green reflects on the last 30 years since the launch of the Human Genome Project.
… Institute of Mental Health, recently published a set of studies describing how DNA variation can alter gene expression. The group of papers, … describes the largest and most comprehensive catalog of genomic variants that affect gene expression produced to … Stephanie Morris about the Institute’s new Impact of Genomic Variation on Function (IGVF) program. As featured in …
The Genomics Landscape
In the October 2019 edition of The Genomics Landscape, NHGRI Director Eric Green focuses on recent efforts to make the human genome reference sequence useful to basic and clinical researchers and how increasing the representation of human genomic variation will remain key components of NHGRI’s Human Genome Reference Program.
… Research studies that generate genome-sequence data rely on a … a single actual human or a representation of human genomic variation. A reference sequence provides researchers a set of … Genetics and Genomics (ACMG) established a fellowship in Genomic Medicine Program Management – a two-year opportunity …
News Release
National Institutes of Health researchers have discovered a specific network of proteins that is necessary to restore hearing in zebrafish through cell regeneration. The study may inform the development of treatments for hearing loss in humans.
… and zebrafish are visually quite different, but at a genomic level, they share more than 70% of their genes. This genomic similarity offers the potential for researchers to … would like to unravel.” Using a combination of genomic techniques and computational-based machine learning, …
News Release
In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease.
… ancestral groups substantially improves identification of genomic variants associated with blood lipid levels. … ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood … To have a fuller understanding of the effects of genomic variation on disease, researchers urge the need to include as …
News Release
A new study by researchers at the National Human Genome Research Institute (NHGRI) is challenging traditional practices for validating DNA sequencing results.
… more accurate than newer methods." In addition, several studies in recent years have suggested that NGS can identify differences in the DNA sequence - called genomic variants - as accurately as Sanger sequencing. To … an NHGRI DNA sequencing project aimed at examining the genomic make-up of 1,500 mostly healthy individuals. Dr. …
Educational Resources
The founder effect is the reduction in genetic variation that results when a small subset of a large population is used to establish a new colony.
… The founder effect is the reduction in genetic variation that results when a small subset of a large … Genetic Variation, Population Genetics, Human Migration, Genes … effect, as related to genetics, refers to the reduction in genomic variability that occurs when a small group of …
News Release
The newly launched Impact of Genomic Variation on Function (IGVF) consortium to include 30 U.S. sites.
… The newly launched Impact of Genomic Variation on Function (IGVF) consortium to include 30 U.S. … $185 million over five years to the Impact of Genomic Variation on Function (IGVF) consortium, initiated and funded … The newly launched Impact of Genomic Variation on Function (IGVF) consortium to include 30 …
News Release
NIH will fund researchers to develop computational approaches to figure out which differences in DNA make people more susceptible to disease.
… predictions about which variants in non-protein-coding genomic regions affect disease susceptibility and response to … are made and in which tissues. "Variants in non-coding genomic regions are harder to interpret than variants in the … Lisa Brooks, Ph.D., program director of the NHGRI Genomic Variation Program. "When many variants in a region are …
15 Ways Genomics Influences Our World
Genomics is advancing the study of individual and communities of microbes.
News Release
An international team of researchers including NIH has completed the first comprehensive characterization of genomic diversity across sub-Saharan Africa.
… has completed the first comprehensive characterization of genomic diversity across sub-Saharan Africa. The region is the most genetically diverse in the world, yet few studies have looked into genomic risk factors for disease in Africa. … genotyping and whole-genome sequence data to explore the genomic-variation landscape of several African …