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News Release
A new study highlights how genomic mutations that cause mitochondrial disease may also compromise affected people's immune response.
… A new study highlights how genomic mutations that cause mitochondrial disease may also … A new study highlights how genomic mutations that cause mitochondrial disease may also … A new study highlights how genomic mutations that cause mitochondrial disease may also …
News Release
The largest genomic study on type 2 diabetes in Africans to date has recently been published in Nature Communications and reports the most recent findings of the ongoing Africa America Diabetes Mellitus (AADM) study that has been led by Dr. Charles Rotimi for over two decades.
… The largest genomic study on type 2 diabetes in Africans to date has … of studying diverse populations. By conducting functional studies of this locus in zebrafish and mice, researchers … The largest genomic study on type 2 diabetes in Africans to date has … The largest genomic study on type 2 diabetes in Africans to date has …
Fact Sheets
Genomics is the study of all of a person's genes (the genome), including interactions of those genes with each other and with the person's environment.
… that could be used for a broad range of biomedical studies. One such use is to look for the genetic variations … human DNA generated by the Human Genome Project and other genomic research, scientists and clinicians have more … a decade for a company to conduct the kinds of clinical studies needed to receive approval from the Food and Drug …
The Genomics Landscape
In the October 1, 2020 edition of The Genomics Landscape, Dr. Eric Green reflects on the last 30 years since the launch of the Human Genome Project.
… Institute of Mental Health, recently published a set of studies describing how DNA variation can alter gene expression. The group of papers, … describes the largest and most comprehensive catalog of genomic variants that affect gene expression produced to … Stephanie Morris about the Institute’s new Impact of Genomic Variation on Function (IGVF) program. As featured in …
The Genomics Landscape
In the October 2019 edition of The Genomics Landscape, NHGRI Director Eric Green focuses on recent efforts to make the human genome reference sequence useful to basic and clinical researchers and how increasing the representation of human genomic variation will remain key components of NHGRI’s Human Genome Reference Program.
… Research studies that generate genome-sequence data rely on a … a single actual human or a representation of human genomic variation. A reference sequence provides researchers a set of … Genetics and Genomics (ACMG) established a fellowship in Genomic Medicine Program Management – a two-year opportunity …
News Release
National Institutes of Health researchers have discovered a specific network of proteins that is necessary to restore hearing in zebrafish through cell regeneration. The study may inform the development of treatments for hearing loss in humans.
… and zebrafish are visually quite different, but at a genomic level, they share more than 70% of their genes. This genomic similarity offers the potential for researchers to … would like to unravel.” Using a combination of genomic techniques and computational-based machine learning, …
News Release
A new study by researchers at the National Human Genome Research Institute (NHGRI) is challenging traditional practices for validating DNA sequencing results.
… more accurate than newer methods." In addition, several studies in recent years have suggested that NGS can identify differences in the DNA sequence - called genomic variants - as accurately as Sanger sequencing. To … an NHGRI DNA sequencing project aimed at examining the genomic make-up of 1,500 mostly healthy individuals. Dr. …
News Release
In a large-scale study of people from diverse ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood lipid levels and generated a polygenic risk score to predict elevated low-density lipoprotein cholesterol levels, a major risk factor for heart disease.
… ancestral groups substantially improves identification of genomic variants associated with blood lipid levels. … ancestries, researchers narrowed down the number of genomic variants that are strongly associated with blood … To have a fuller understanding of the effects of genomic variation on disease, researchers urge the need to include as …
Educational Resources
The founder effect is the reduction in genetic variation that results when a small subset of a large population is used to establish a new colony.
… The founder effect is the reduction in genetic variation that results when a small subset of a large … Genetic Variation, Population Genetics, Human Migration, Genes … effect, as related to genetics, refers to the reduction in genomic variability that occurs when a small group of …
News Release
The newly launched Impact of Genomic Variation on Function (IGVF) consortium to include 30 U.S. sites.
… The newly launched Impact of Genomic Variation on Function (IGVF) consortium to include 30 U.S. … $185 million over five years to the Impact of Genomic Variation on Function (IGVF) consortium, initiated and funded … The newly launched Impact of Genomic Variation on Function (IGVF) consortium to include 30 …