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News Release
A new study by researchers at the National Human Genome Research Institute (NHGRI) is challenging traditional practices for validating DNA sequencing results.
… A new study by researchers at the National Human Genome Research Institute (NHGRI) is challenging traditional … to supplant Sanger sequencing because of its ability to sequence millions of pieces of DNA at the same time - … The current standard "best practice" in some clinical genome sequencing laboratories requires positive NGS findings …
Educational Resources
DNA sequencing is a laboratory technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA molecule.
… is a laboratory technique used to determine the exact sequence of bases (A, C, G, and T) in a DNA molecule. … the general laboratory technique for determining the exact sequence of nucleotides, or bases, in a DNA molecule. The … understanding the function of genes and other parts of the genome. There are now several different methods available for …
News Release
On June 26, 2000, nearly 10 years into the 13-year project, President Bill Clinton announced an important milestone for the Human Genome Project at a major White House ceremony.
… The signature goal of the Human Genome Project (HGP) was to generate a sequence of the three billion letters (A, C, G and T) in the … 20th anniversary of White House event announcing draft human genome sequence … Bill Clinton announced an important milestone for the Human Genome Project at a major White House ceremony. …
Profile
Jim Mullikin pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics.
… Mullikin pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics. … career are you most proud of? Jim Mullikin: Of course, the Human Genome Project is one of the top ones. I started working on … than $1,000, which was always a big goal following the Human Genome Project.  These new technologies opened up many …
Fact Sheets
Comparative genomics is a field of biological research in which researchers compare the complete genome sequences of different species.
… researchers use a variety of tools to compare the complete genome sequences of different species. By carefully comparing … of years - is an important step toward understanding the genome itself. It pinpoints genes that are essential to life … turn may translate into innovative approaches for treating human disease and improving human health. Comparative …
Fact Sheets
DNA sequencing determines the order of the four chemical building blocks - called "bases" - that make up the DNA molecule.
… - called "bases" - that make up the DNA molecule. The sequence tells scientists the kind of genetic information … by which most DNA sequencing experiments are done. The human genome contains about 3 billion base pairs that spell out the … Since the completion of the Human Genome Project, technological improvements and …
Research Funding
GS-IT provides sequence analysis tools and software to scientists who rely on genomics in their research.
… researchers. This includes software dedicated to sequence quality, alignment, assembly, variant calling, … Genome Sequencing Informatics Tools (GS-IT) provides "researcher friendly" sequence analysis tools and software to a broad community of … Genome Sequencing Informatics Tools …
Talking Glossary
Next-generation DNA sequencing (abbreviated NGS) refers to the use of technologies for sequencing DNA that became available shortly after the completion of the Human Genome Project (which relied on the first-generation method of Sanger sequencing).
… that became available shortly after the completion of the Human Genome Project (which relied on the first-generation method … that became available shortly after the completion of the Human Genome Project (which relied on the first-generation method … that became available shortly after the completion of the Human Genome Project (which relied on the first-generation …
News Release
A team of NIH-funded researchers have generated the first complete chromosome sequences from non-human primates.
… generated the first complete chromosome sequences from non-human primates. Published in Nature , these sequences uncover … Ph.D., a postdoctoral fellow at the National Human Genome Research Institute (NHGRI), part of NIH, and an author of the study. “Only the chimpanzee genome sequence was fairly complete before this, but even that still …
The Genomics Landscape
In the January 2018 edition of The Genomics Landscape, NHGRI Director Eric Green features the NIH Intramural Sequencing Center.
… essentially unchanged in >20 years: provide contemporary genome-sequencing capabilities for intramural researchers at … that mission, regularly generating large amounts of genome-sequence data and analyses for numerous NHGRI and NIH … . Later, NISC became involved in NIH Common Fund's Human Microbiome Project , in which genome sequencing was …