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News Release
New grants totaling approximately $29.5 million will enable scientists to generate and maintain the most comprehensive reference sequence of the human genome.
… by helping them interpret both research and patient genome sequences,” said Adam Felsenfeld, Ph.D., NHGRI program … use the reference genome sequence to assemble genome sequences from individuals. By advancing the quality of the … state-of-the-art technologies to incorporate high-quality sequences that are more broadly representative. The amount of …
Fact Sheets
Comparative genomics is a field of biological research in which researchers compare the complete genome sequences of different species.
… use a variety of tools to compare the complete genome sequences of different species. By carefully comparing … Identifying DNA sequences that have been "conserved" - that is, preserved in … genes that code for different proteins and the regulatory sequences that turn those genes on and off. Precisely which …
Staff
Dr. Gerard Bouffard directs the Bioinformatics Group at the NIH Intramural Sequencing Center (NISC).
… W., Green E.D. Comparative analyses of multi-species sequences from targeted genomic regions. Nature, … Context-dependent Mutation Rates Using Primate Genomic Sequences. J Mol Evol , 65(3):207-14. 2007. [ PubMed ] Grice … ED. Effort required to finish shotgun-generated genome sequences differs significantly among vertebrates. BMC …
Staff
Dr. Mullikin was the former director of the NIH Intramural Sequencing Center (NISC).
… ] Yuhki N, Mullikin JC, Beck T, Stephens R and O'Brien SJ. Sequences, annotation and single nucleotide polymorphism of …
News Release
A team of NIH-funded researchers have generated the first complete chromosome sequences from non-human primates.
… Complete X and Y chromosome sequences from six primate species reveal species diversity … of Health have generated the first complete chromosome sequences from non-human primates. Published in Nature , these sequences uncover remarkable variation between the Y …
The Genomics Landscape
In the April 7, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., highlights the Telomere-to-Telomere (T2T) consortium's publishing of a collection of papers that reported the first truly complete sequence of the human genome.
… its first genomic dataset , including whole-genome sequences from nearly 100,000 participants from diverse … first genomic dataset of nearly 100,000 whole genome sequences All of Us: Release of nearly 100,000 whole genome sequences sets stage for new discoveries Notable …
Educational Resources
Cloning is the process of making identical copies of an organism, cell, or DNA sequence.
The Genomics Landscape
In the October 6, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., celebrates the 25th anniversary of the NIH Intramural Sequencing Center (NISC). a well-respected and highly used large-scale DNA sequencing center that exemplifies the evolution of the field of genomics and the ever-increasing abilities to produce prodigious amounts of genomic data.
… Collection (MGC), a program that generated high-quality sequences of a reference set of cDNA clones representing …
Clinical Research
This team-based clinical service is provided by NHGRI to Intramural Investigators employing exome/genome sequencing.
News Release
NHGRI will fund a set of genome sequencing and analysis centers whose research will focus on understanding the genomic bases of common and rare human diseases.