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News Release
NHGRI researchers have identified new genes associated with the Erdheim-Chester disease (ECD) and some possible new therapies.
… seen in colon cancer, lung cancer, thyroid cancer, brain tumors and some blood cancers. Other patients had mutations …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… codes for a protein that normally suppresses the growth of tumors by arresting cell division. Humans born with mutations … with more than half of human cancers and often lead to tumors in a particular set of tissues. However, when the p53 gene is knocked out in mice, the animals develop tumors in a different array of tissues.Despite these …
Fact Sheets
Epigenomics is a field in which researchers chart the locations and understand the functions of all the chemical tags that mark the genome.
… of cancer, or to a failure of the immune system to destroy tumors. In a type of brain tumor called glioblastoma, doctors … that counteracts temozolomide. Glioblastoma patients whose tumors have such methylated genes are far more likely to …
News Release
A genetic mutation that triggers bladder cancer in dogs is identical to a mutation that is implicated in multiple human cancers.
… BRAF -targeted therapy strategies," they added. Canine tumors carrying the mutation also offer a new environment for … high frequency of the mutation, examination of the dog tumors might enable us to determine why this particular …
Staff
Dr. Eggerton Campbell is a senior licensing and patenting manager in the Technology Transfer Office at the National Human Genome Research Institute. ​
… nucleic acid amplification (PCR), detection of tumors/cancer via mutations, recombinant polypeptides, human …
Fact Sheets
A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
… biological pathways and the genetic profiles of particular tumors, drug developers might be able to focus their … likely to repair the pathways affected in their particular tumors. …
Staff
Dr. Heidi Parker is an Associate Investigator in the Comparative Genetics Section of the Cancer Genetics and Comparative Genomics Branch, NHGRI.
… and complex trait mapping and genomic analysis of canine tumors. The primary goal of Dr. Parker’s research is to use … and shared regions of dysregulation with human bladder tumors . BMC Cancer 24;20(1):251, 2020. Parker HG*, Whitaker …
The Genomics Landscape
In the June 2018 issue of The Genomics Landscape, NHGRI Director Eric Green highlights the success of The Cancer Genome Atlas.
… with an unprecedented understanding of how, where, and why tumors arise in humans, enabling better informed clinical …
Event
On February 16, 2023, the National Human Genome Research Institute (NHGRI) held a follow-up working group consultation after the 14th Genomic Medicine meeting, Genomic Medicine XIV: Genomic Learning Healthcare Systems.
Jobs at NHGRI
Postdoctoral positions are available in the laboratory of Dr. Daphne W. Bell, within the Cancer Genetics and Comparative Genomics Branch of the National Human Genome Research Institute, at NIH.