Search Results
News Release
Investigators with The Cancer Genome Atlas Research Network have identified new potential therapeutic targets for a major form of bladder cancer.
… (which is commonly affected in cancers) in 44 percent of tumors. TP53 makes the p53 tumor suppressor protein, which … identified potential drug targets in 69 percent of the tumors evaluated. They found frequent mutations in the ERBB2 … responsible for cervical cancer - was found in bladder tumors. This suggests that viral infection can contribute to …
News Release
A new phase of the IGNITE Network will conduct clinical trials of genomic medicine interventions.
… treatment of high blood pressure, hypertension and chronic kidney disease. Both hypertension and high blood pressure exacerbate end-stage kidney diseases, and all three conditions are more common … L1 ( APOL1 ) gene that increase susceptibility to severe kidney disease by a factor of 10. Researchers will compare …
News Release
The TCGA network describes uterine and bile duct cancer.
… uncontrolled cell growth that is the hallmark of malignant tumors. Last month, two publications from the TCGA network …
News Release
Researchers have discovered that FGF21 is elevated in mice with liver disease that mimics the same condition in patients with methylmalonic acidemia.
… ease some of the symptoms, but do not cure the disease. Kidney transplantation, on the other hand, is necessary when … patients would benefit from a liver or combined liver/kidney transplant as opposed to just a kidney transplant is an important clinical decision for …
Clinical Research
This study evaluates patients with inherited metabolic disorders and related medical complications.
… problems such as strokes, seizures and low muscle tone, kidney problems, poor vision, and metabolic instability … problems such as strokes, seizures and low muscle tone, kidney problems, poor vision, and metabolic instability … system, rehabilitation, digestive tract, endocrine and kidney, as needed. A 24-hour urine collection to examine for …
Research at NHGRI
CRGGH facilitates understanding of the relationship between genetic variation and population differences in disease distribution to inform health disparities.
… obesity, hypertension, diabetes, dyslipidemia, and kidney diseases, in different human populations with …
Fact Sheets
Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).
… (Herceptin). This therapy works only for women whose tumors have a particular genetic profile that leads to … ability to develop into every type of tissue (skin, liver, kidney, blood, etc.) found in an adult human. Adult stem …
Educational Resources
Sickle cell disease is a hereditary disease seen most often among people of African ancestry.
Staff
Elaine Ostrander is chief of NHGRI's Cancer Genetics and Comparative Genomics Branch.
… the utility of dogs for cancer genetics by mapping kidney cystadeno-carcinoma in German Shepherds, prior to its … of the bladder 27, 28 , and canine transmissible venereal tumors 29 . Prostate Cancer : We have worked for the last … landscape of BRCA2-associated aggressive prostate tumors, defining a signature of an increased somatic mutation …