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Fact Sheet
Pharmacogenomics is a growing area of genomic medicine that uses a patient's genomic information to help healthcare providers select the medications and dosages that are predicted to work best in each patient.
Research at NHGRI
The NHGRI Cancer Genetics and Comparative Genomics Branch identifies and study genes that contribute to cancer susceptibility and progression.
… that lead, specifically, to fast-growing and aggressive tumors. Formation or production of tumors-tumorigenesis-can result from genomic alterations that … Identifies somatic genomic alterations that drive sporadic tumors using whole-exome and whole-genome sequencing …
Media Advisory
On August 16-18, 2017, NIH hosted a workshop, "The Human Microbiome: Emerging Themes at the Horizon of the 21st Century."
… impact human development, physiology, immunity, brain development and behavior, and to create research …
Genetic Disorders
WAGR syndrome is a genetic condition caused by a deletion of genes located on chromosome 11, often causing eye problems and increased risk of cancer in babies.
Staff
Dr. Mo is an adjunct staff clinician in the Hematology Laboratory, Department of Laboratory Medicine in the NIH Clinical Center.
… modifies the DNA methylation landscape in the adult brain . Nat Neurosci. 2011;14(10), 1345–1351. …
Staff
Abdel Elkahloun is an associate investigator in NHGRI's Office of Scientific Core Facilities.
… University of Michigan for the study of sarcomas and solid tumors and then joined the National Human Genome Research … of the Hippocampal Transcriptome Following Mild Traumatic Brain Injury After Controlled Cortical Impact in the Rat. J …
News Release
Investigators with The Cancer Genome Atlas have discovered genomic differences in head and neck cancers caused by infection with the human papillomavirus.
… head and neck cancers, noticeably in oropharyngeal tumors, has created an even greater sense of urgency in the … behind the mouth. "We're uncovering differences between tumors with and without HPV infection, and these new data are … the study, researchers performed genomic analyses on 279 tumors - head and neck squamous cell carcinomas (HNSCC) - …
Diversity Center
Tuskegee University establishes the Carver Genomic Research Center.
… tumor microenvironment or immune contexture of the tumors However, many cancer patients do not participate in …
News Release
Investigators with The Cancer Genome Atlas Research Network have identified new potential therapeutic targets for a major form of bladder cancer.
… (which is commonly affected in cancers) in 44 percent of tumors. TP53 makes the p53 tumor suppressor protein, which … identified potential drug targets in 69 percent of the tumors evaluated. They found frequent mutations in the ERBB2 … responsible for cervical cancer - was found in bladder tumors. This suggests that viral infection can contribute to …
Fact Sheet
With increasing complexity in genomic data, researchers are turning to artificial intelligence and machine learning as ways to identify meaningful patterns for healthcare and research purposes.
… patterns and critical information by imitating how a human brain’s neurons interact with each other. The algorithms are … neural networks — a computing system that simulates the brain’s ability to weigh the importance of some data versus …