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Educational Resources
Apoptosis is the process of programmed cell death.
… Apoptosis is the process of programmed cell death. … Programmed Cell Death, Development, DNA Repair, Cancer, Tumor, Cell Division … Apoptosis is the process of programmed cell death. It is used during early development to eliminate … beyond repair. Apoptosis also plays a role in preventing cancer. If apoptosis is for some reason prevented, it can …
News Release
NIH researchers searched for how the body signals the lack of oxygen in melanoma skin cancer.
… the oxygen and nutrients in the original tumor site, the cancer cells travel to other parts of the body (metastasize) … how the body signals the lack of oxygen in melanoma skin cancer, National Institutes of Health (NIH) researchers … They published their findings February 6, 2017, in Pigment Cell and Melanoma Research . "These newly identified genes …
Fact Sheet
Gene therapy for sickle cell disease is available to you through FDA-approved therapies and through clinical trials.
… Gene therapy for sickle cell disease is available to you through FDA-approved … . While there are a number of clinical trials for sickle cell gene therapy, the journey can be similar across all … therapy may depend on: Your age. Your diagnosis of sickle cell disease. Your response to other treatments. Whether you …
News Release
Researchers explored patients', parents' and physicians' perspectives on the use of CRISPR-Cas9 gene-editing to reverse sickle cell disease.
… on the use of CRISPR-Cas9 gene-editing to reverse sickle cell disease (SCD). … expressed overall optimism about participating in human genome editing clinical trials, but were concerned about … Heart, Lung, and Blood Institute launched the Cure Sickle Cell Initiative  to accelerate development of the most …
News Release
NHGRI researchers seek help from people with Sickle Cell Disease to find the factors - environmental, social and genetic - that impact the severity of symptoms.
… People with sickle cell disease (SCD) can experience excruciating pain all over … Researchers at the National Human Genome Research Institute (NHGRI) are seeking help from … severity of SCD symptoms. "Scientists identified sickle cell anemia in 1910, but there is still much to learn about …
Educational Resources
The genome is the entire set of genetic instructions found in a cell.
… Genome … The genome is the entire set of genetic instructions found in a cell. … Genome, Genomics, DNA Sequence, Human Genome Project, Genes … The genome is the entire set of DNA instructions found in a cell. … is the entire set of genetic instructions found in a cell. …
Educational Resources
A tumor suppressor gene directs the production of a protein that is part of the system that regulates cell division.
… of a protein that is part of the system that regulates cell division. … BRCA1, BRCA2, Cancer, Oncogene, Cell, Gene, Mutation … suppressor gene encodes a protein that acts to regulate cell division, keeping it in check. When a tumor suppressor … Such mutations may contribute to the development of a cancer. …
Media Availability
Researchers have created a promising new method to accurately and more comprehensively analyze and interpret DNA sequence information from cancer patients.
… analyze and interpret DNA sequence information from cancer patients. They have developed an algorithm that sorts … to their clinical and biological relevance to a patient's cancer. … Human Genome Research Institute (NHGRI), and the National Cancer Institute, both part of the National Institutes of …
Educational Resources
A carcinogen is an agent with the capacity to cause cancer in humans.
… A carcinogen is an agent with the capacity to cause cancer in humans. … Cancer, Tumor, Genetic Mutation, Chemical … is a substance, organism or agent capable of causing cancer. Carcinogens may occur naturally in the environment … smoke). Most carcinogens work by interacting with a cell’s DNA to produce mutations. …
Staff
Dr. Paul Meltzer is an adjunct investigator in NHGRI's Cancer Genetics and Comparative Genomics Branch.
… Dr. Meltzer is a leader in the application of genome science to cancer research. His recent studies investigate the genetic … a program focused on the mechanisms and consequences of genome instability, non-coding RNA biology, and translational … Asian Hepatocellular Carcinoma and Cholangiocarcinoma . Cancer Cell , 32(1):57-70.e3. 2017. Killian JK, Dorssers LC, …