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Fact Sheet
Pharmacogenomics is a growing area of genomic medicine that uses a patient's genomic information to help healthcare providers select the medications and dosages that are predicted to work best in each patient.
… medications. A person’s DNA contains genomic variants that influence how their body handles that medication. Because of … variants can change the structure of these proteins and influence how they break down or activate certain substances, … variants within the gene encoding that receptor can influence things like the shape of the receptor or how many …
Research Funding
NHGRI is initiating a new program-the Impact of Genomic Variation on Function (IGVF) Consortium to develop a framework for systematically understanding the effects of genomic variation on genome function and how these effects shape phenotypes.
… how genomic variation affects genome function to influence phenotypes. NHGRI initiated a new program, the …  Advancement of network-level understanding of the influence of genetic variation and genome function on … Date: November 5, 2020  RFA-HG-20-044 : Defining Genomic Influence on Gene Network Regulation (U01 Clinical Trial Not …
Research at NHGRI
The Immersive Simulation Program (ISP) provides expertise, tools, and support for the integration of emerging technology-based methods into health and medical research.
… Investigating the influence of patient characteristics on pharmacogenetics … Assessment of genomic messaging approaches on parental feeding behavior PI: Susan Persky, Ph.D. Health … how variations in immersive applications and interventions influence psychological experience, biological response, and …
Staff
Dr. Susan Persky is an associate investigator in the Social and Behavioral Research Branch at the National Human Genome Research Institute.
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… of VR for heightening the immersion and psychological influence of media. This work underscores the potential of … information tends to be variable with respect to its influence on the attitudes and beliefs that underlie patient … genomic information about obesity, however, does not influence all patients in the same way. Dr. Persky and her …
News Release
A simple blood draw is replacing a giant needle to the belly for testing their fetuses for a range of genetic disorders.
… complex information about a fetus' genome could increase parental anxiety. This, in turn, could lead to overtreatment … issues such a paradigm-shifting technology raises and influence the direction of professional guidance documents." …
Health
A polygenic risk score is one way by which people can learn what their risk of developing a disease is, based on the total number of genomics variants related to the disease.
… risk. The question is: How do these genomic variants influence the risk for specific diseases? Image shows genomic …
Fact Sheets
Estimated cost of sequencing the human genome over time since the Human Genome Project.
… for sequencing genomes are of great interest because they influence the scope and scale of almost all genomics research …
Profile
An interview with Meru Sadhu, an Earl Stadtman Investigator and head of the systems biology and genome engineering section within the NHGRI Intramural Research Program, where he talks about his research and why yeast have a special place in his heart.
… understand how each of those variants and the environment influence the particular traits. …
The Genomics Landscape
In the October 2023 edition of The Genomics Landscape, NHGRI Director Eric Green, reflects on the twelve years of groundbreaking research by the Clinical Sequencing Evidence-generating Research (CSER) consortium.
… of times. In this study, researchers explored the influence that VNTRs have on human traits, particularly … disease risk. They found more than 50 VNTRs that influence human traits. Further, they found that two VNTRs … in this case the TMCO1 and EIF3H genes, had a larger influence on the risk for glaucoma and colorectal cancer, …
News Release
Mothers may be able to reduce guilt over their children's inherited obesity guilt by being more careful in the future about their children's diet.
… may not realize the extent to which genetic factors could influence metabolism, as well as the behavioral underpinnings … risk. Seventy-three of the women were told only about the influence of lifestyle - too much time watching television, …